3TO8

Crystal structure of the two C-terminal RRM domains of heterogeneous nuclear ribonucleoprotein L (hnRNP L)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0005634	cellular_component	nucleus
A	0006397	biological_process	mRNA processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 1

Chain	Residue
A	SER471
A	CYS472
A	LYS475
A	ARG495
A	GLN497
A	HIS504
A	SER583
A	THR584

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 590

Chain	Residue
A	ASP397
A	PHE400
A	ASN401
A	SER480
A	ASN482
A	PEG591
A	HOH48

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PEG A 591

Chain	Residue
A	HOH6
A	HOH36
A	HOH62
A	ARG398
A	ASN401
A	HIS564
A	GLN566
A	GOL590

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 2

Chain	Residue
A	ASP433
A	ARG434
A	ASN516
A	ILE520
A	TYR565
A	MET567
A	LYS568

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	96
Details	Domain: {"description":"RRM 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8R081","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by CaMK4","evidences":[{"source":"PubMed","id":"22570490","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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