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3TNP

Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme

Functional Information from GO Data
ChainGOidnamespacecontents
B0000166molecular_functionnucleotide binding
B0001932biological_processregulation of protein phosphorylation
B0004862molecular_functioncAMP-dependent protein kinase inhibitor activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005952cellular_componentcAMP-dependent protein kinase complex
B0006631biological_processfatty acid metabolic process
B0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
B0007612biological_processlearning
B0008603molecular_functioncAMP-dependent protein kinase regulator activity
B0019901molecular_functionprotein kinase binding
B0019904molecular_functionprotein domain specific binding
B0030425cellular_componentdendrite
B0030552molecular_functioncAMP binding
B0031625molecular_functionubiquitin protein ligase binding
B0034236molecular_functionprotein kinase A catalytic subunit binding
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0043198cellular_componentdendritic shaft
B0048471cellular_componentperinuclear region of cytoplasm
B0050804biological_processmodulation of chemical synaptic transmission
B0097332biological_processresponse to antipsychotic drug
B0097546cellular_componentciliary base
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0141162biological_processnegative regulation of cAMP/PKA signal transduction
C0000166molecular_functionnucleotide binding
C0000287molecular_functionmagnesium ion binding
C0001669cellular_componentacrosomal vesicle
C0001707biological_processmesoderm formation
C0001843biological_processneural tube closure
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004691molecular_functioncAMP-dependent protein kinase activity
C0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005811cellular_componentlipid droplet
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005930cellular_componentaxoneme
C0005952cellular_componentcAMP-dependent protein kinase complex
C0006338biological_processchromatin remodeling
C0006397biological_processmRNA processing
C0006468biological_processprotein phosphorylation
C0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
C0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
C0008284biological_processpositive regulation of cell population proliferation
C0010898biological_processpositive regulation of triglyceride catabolic process
C0016020cellular_componentmembrane
C0016301molecular_functionkinase activity
C0016607cellular_componentnuclear speck
C0016740molecular_functiontransferase activity
C0019901molecular_functionprotein kinase binding
C0019904molecular_functionprotein domain specific binding
C0030007biological_processintracellular potassium ion homeostasis
C0030145molecular_functionmanganese ion binding
C0031267molecular_functionsmall GTPase binding
C0031410cellular_componentcytoplasmic vesicle
C0031514cellular_componentmotile cilium
C0031588cellular_componentnucleotide-activated protein kinase complex
C0031594cellular_componentneuromuscular junction
C0031625molecular_functionubiquitin protein ligase binding
C0031669biological_processcellular response to nutrient levels
C0032991cellular_componentprotein-containing complex
C0034237molecular_functionprotein kinase A regulatory subunit binding
C0034605biological_processcellular response to heat
C0036126cellular_componentsperm flagellum
C0038110biological_processinterleukin-2-mediated signaling pathway
C0038202biological_processTORC1 signaling
C0043457biological_processregulation of cellular respiration
C0044853cellular_componentplasma membrane raft
C0044877molecular_functionprotein-containing complex binding
C0045542biological_processpositive regulation of cholesterol biosynthetic process
C0045667biological_processregulation of osteoblast differentiation
C0045722biological_processpositive regulation of gluconeogenesis
C0045820biological_processnegative regulation of glycolytic process
C0045879biological_processnegative regulation of smoothened signaling pathway
C0046827biological_processpositive regulation of protein export from nucleus
C0048240biological_processsperm capacitation
C0048471cellular_componentperinuclear region of cytoplasm
C0048792biological_processspontaneous exocytosis of neurotransmitter
C0050766biological_processpositive regulation of phagocytosis
C0050804biological_processmodulation of chemical synaptic transmission
C0051447biological_processnegative regulation of meiotic cell cycle
C0051726biological_processregulation of cell cycle
C0051966biological_processregulation of synaptic transmission, glutamatergic
C0061136biological_processregulation of proteasomal protein catabolic process
C0070417biological_processcellular response to cold
C0070613biological_processregulation of protein processing
C0071333biological_processcellular response to glucose stimulus
C0071374biological_processcellular response to parathyroid hormone stimulus
C0071377biological_processcellular response to glucagon stimulus
C0097225cellular_componentsperm midpiece
C0097546cellular_componentciliary base
C0098793cellular_componentpresynapse
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099170biological_processpostsynaptic modulation of chemical synaptic transmission
C0106310molecular_functionprotein serine kinase activity
C0140198molecular_functionhistone H1-4S35 kinase activity
C0141156biological_processcAMP/PKA signal transduction
C1904262biological_processnegative regulation of TORC1 signaling
C1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
C1990044biological_processprotein localization to lipid droplet
C2000810biological_processregulation of bicellular tight junction assembly
E0000166molecular_functionnucleotide binding
E0001932biological_processregulation of protein phosphorylation
E0004862molecular_functioncAMP-dependent protein kinase inhibitor activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005813cellular_componentcentrosome
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0005952cellular_componentcAMP-dependent protein kinase complex
E0006631biological_processfatty acid metabolic process
E0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
E0007612biological_processlearning
E0008603molecular_functioncAMP-dependent protein kinase regulator activity
E0019901molecular_functionprotein kinase binding
E0019904molecular_functionprotein domain specific binding
E0030425cellular_componentdendrite
E0030552molecular_functioncAMP binding
E0031625molecular_functionubiquitin protein ligase binding
E0034236molecular_functionprotein kinase A catalytic subunit binding
E0043025cellular_componentneuronal cell body
E0043197cellular_componentdendritic spine
E0043198cellular_componentdendritic shaft
E0048471cellular_componentperinuclear region of cytoplasm
E0050804biological_processmodulation of chemical synaptic transmission
E0097332biological_processresponse to antipsychotic drug
E0097546cellular_componentciliary base
E0098794cellular_componentpostsynapse
E0098978cellular_componentglutamatergic synapse
E0141162biological_processnegative regulation of cAMP/PKA signal transduction
F0000166molecular_functionnucleotide binding
F0000287molecular_functionmagnesium ion binding
F0001669cellular_componentacrosomal vesicle
F0001707biological_processmesoderm formation
F0001843biological_processneural tube closure
F0004672molecular_functionprotein kinase activity
F0004674molecular_functionprotein serine/threonine kinase activity
F0004691molecular_functioncAMP-dependent protein kinase activity
F0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005811cellular_componentlipid droplet
F0005813cellular_componentcentrosome
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005930cellular_componentaxoneme
F0005952cellular_componentcAMP-dependent protein kinase complex
F0006338biological_processchromatin remodeling
F0006397biological_processmRNA processing
F0006468biological_processprotein phosphorylation
F0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
F0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
F0008284biological_processpositive regulation of cell population proliferation
F0010898biological_processpositive regulation of triglyceride catabolic process
F0016020cellular_componentmembrane
F0016301molecular_functionkinase activity
F0016607cellular_componentnuclear speck
F0016740molecular_functiontransferase activity
F0019901molecular_functionprotein kinase binding
F0019904molecular_functionprotein domain specific binding
F0030007biological_processintracellular potassium ion homeostasis
F0030145molecular_functionmanganese ion binding
F0031267molecular_functionsmall GTPase binding
F0031410cellular_componentcytoplasmic vesicle
F0031514cellular_componentmotile cilium
F0031588cellular_componentnucleotide-activated protein kinase complex
F0031594cellular_componentneuromuscular junction
F0031625molecular_functionubiquitin protein ligase binding
F0031669biological_processcellular response to nutrient levels
F0032991cellular_componentprotein-containing complex
F0034237molecular_functionprotein kinase A regulatory subunit binding
F0034605biological_processcellular response to heat
F0036126cellular_componentsperm flagellum
F0038110biological_processinterleukin-2-mediated signaling pathway
F0038202biological_processTORC1 signaling
F0043457biological_processregulation of cellular respiration
F0044853cellular_componentplasma membrane raft
F0044877molecular_functionprotein-containing complex binding
F0045542biological_processpositive regulation of cholesterol biosynthetic process
F0045667biological_processregulation of osteoblast differentiation
F0045722biological_processpositive regulation of gluconeogenesis
F0045820biological_processnegative regulation of glycolytic process
F0045879biological_processnegative regulation of smoothened signaling pathway
F0046827biological_processpositive regulation of protein export from nucleus
F0048240biological_processsperm capacitation
F0048471cellular_componentperinuclear region of cytoplasm
F0048792biological_processspontaneous exocytosis of neurotransmitter
F0050766biological_processpositive regulation of phagocytosis
F0050804biological_processmodulation of chemical synaptic transmission
F0051447biological_processnegative regulation of meiotic cell cycle
F0051726biological_processregulation of cell cycle
F0051966biological_processregulation of synaptic transmission, glutamatergic
F0061136biological_processregulation of proteasomal protein catabolic process
F0070417biological_processcellular response to cold
F0070613biological_processregulation of protein processing
F0071333biological_processcellular response to glucose stimulus
F0071374biological_processcellular response to parathyroid hormone stimulus
F0071377biological_processcellular response to glucagon stimulus
F0097225cellular_componentsperm midpiece
F0097546cellular_componentciliary base
F0098793cellular_componentpresynapse
F0098794cellular_componentpostsynapse
F0098978cellular_componentglutamatergic synapse
F0099170biological_processpostsynaptic modulation of chemical synaptic transmission
F0106310molecular_functionprotein serine kinase activity
F0140198molecular_functionhistone H1-4S35 kinase activity
F0141156biological_processcAMP/PKA signal transduction
F1904262biological_processnegative regulation of TORC1 signaling
F1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
F1990044biological_processprotein localization to lipid droplet
F2000810biological_processregulation of bicellular tight junction assembly
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhkesgnh..........YAMK
ChainResidueDetails
CLEU49-LYS72

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI
ChainResidueDetails
CLEU162-ILE174

site_idPS00888
Number of Residues17
DetailsCNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. VIdQGDdGDnFYVIdrG
ChainResidueDetails
BVAL179-GLY195
BILE301-GLY317

site_idPS00889
Number of Residues18
DetailsCNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGElALvtnkp......RAAsAhA
ChainResidueDetails
BPHE348-ALA365

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"description":"Proton acceptor"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues278
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P17612","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22323819","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8395513","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by PDPK1","evidences":[{"source":"PubMed","id":"22323819","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8395513","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9707564","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"21866565","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"8395513","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues8
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16452087","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"17242355","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19131326","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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