3TM6

Crystal structure of the beta-2 microglobulin DIMC50 disulphide-linked homodimer mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0001913	biological_process	T cell mediated cytotoxicity
A	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
A	0002237	biological_process	response to molecule of bacterial origin
A	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
A	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
A	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
A	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
A	0002726	biological_process	positive regulation of T cell cytokine production
A	0005198	molecular_function	structural molecule activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005765	cellular_component	lysosomal membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006955	biological_process	immune response
A	0007608	biological_process	sensory perception of smell
A	0007611	biological_process	learning or memory
A	0009897	cellular_component	external side of plasma membrane
A	0009986	cellular_component	cell surface
A	0010977	biological_process	negative regulation of neuron projection development
A	0012507	cellular_component	ER to Golgi transport vesicle membrane
A	0016020	cellular_component	membrane
A	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
A	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
A	0023026	molecular_function	MHC class II protein complex binding
A	0030670	cellular_component	phagocytic vesicle membrane
A	0031901	cellular_component	early endosome membrane
A	0031902	cellular_component	late endosome membrane
A	0031905	cellular_component	early endosome lumen
A	0032092	biological_process	positive regulation of protein binding
A	0033077	biological_process	T cell differentiation in thymus
A	0034756	biological_process	regulation of iron ion transport
A	0035580	cellular_component	specific granule lumen
A	0042026	biological_process	protein refolding
A	0042605	molecular_function	peptide antigen binding
A	0042612	cellular_component	MHC class I protein complex
A	0042613	cellular_component	MHC class II protein complex
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0042824	cellular_component	MHC class I peptide loading complex
A	0045646	biological_process	regulation of erythrocyte differentiation
A	0048260	biological_process	positive regulation of receptor-mediated endocytosis
A	0050680	biological_process	negative regulation of epithelial cell proliferation
A	0050768	biological_process	negative regulation of neurogenesis
A	0050778	biological_process	positive regulation of immune response
A	0050870	biological_process	positive regulation of T cell activation
A	0051289	biological_process	protein homotetramerization
A	0055038	cellular_component	recycling endosome membrane
A	0060586	biological_process	multicellular organismal-level iron ion homeostasis
A	0070062	cellular_component	extracellular exosome
A	0071281	biological_process	cellular response to iron ion
A	0071283	biological_process	cellular response to iron(III) ion
A	0071316	biological_process	cellular response to nicotine
A	1900121	biological_process	negative regulation of receptor binding
A	1900122	biological_process	positive regulation of receptor binding
A	1904434	biological_process	positive regulation of ferrous iron binding
A	1904437	biological_process	positive regulation of transferrin receptor binding
A	1904724	cellular_component	tertiary granule lumen
A	1990000	biological_process	amyloid fibril formation
A	1990712	cellular_component	HFE-transferrin receptor complex
A	2000774	biological_process	positive regulation of cellular senescence
A	2000978	biological_process	negative regulation of forebrain neuron differentiation
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0032092	biological_process	positive regulation of protein binding
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1900121	biological_process	negative regulation of receptor binding
B	1900122	biological_process	positive regulation of receptor binding
B	1904434	biological_process	positive regulation of ferrous iron binding
B	1904437	biological_process	positive regulation of transferrin receptor binding
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
C	0000139	cellular_component	Golgi membrane
C	0001913	biological_process	T cell mediated cytotoxicity
C	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
C	0002237	biological_process	response to molecule of bacterial origin
C	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
C	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
C	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
C	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
C	0002726	biological_process	positive regulation of T cell cytokine production
C	0005198	molecular_function	structural molecule activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005765	cellular_component	lysosomal membrane
C	0005783	cellular_component	endoplasmic reticulum
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005925	cellular_component	focal adhesion
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0006955	biological_process	immune response
C	0007608	biological_process	sensory perception of smell
C	0007611	biological_process	learning or memory
C	0009897	cellular_component	external side of plasma membrane
C	0009986	cellular_component	cell surface
C	0010977	biological_process	negative regulation of neuron projection development
C	0012507	cellular_component	ER to Golgi transport vesicle membrane
C	0016020	cellular_component	membrane
C	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
C	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
C	0023026	molecular_function	MHC class II protein complex binding
C	0030670	cellular_component	phagocytic vesicle membrane
C	0031901	cellular_component	early endosome membrane
C	0031902	cellular_component	late endosome membrane
C	0031905	cellular_component	early endosome lumen
C	0032092	biological_process	positive regulation of protein binding
C	0033077	biological_process	T cell differentiation in thymus
C	0034756	biological_process	regulation of iron ion transport
C	0035580	cellular_component	specific granule lumen
C	0042026	biological_process	protein refolding
C	0042605	molecular_function	peptide antigen binding
C	0042612	cellular_component	MHC class I protein complex
C	0042613	cellular_component	MHC class II protein complex
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0042824	cellular_component	MHC class I peptide loading complex
C	0045646	biological_process	regulation of erythrocyte differentiation
C	0048260	biological_process	positive regulation of receptor-mediated endocytosis
C	0050680	biological_process	negative regulation of epithelial cell proliferation
C	0050768	biological_process	negative regulation of neurogenesis
C	0050778	biological_process	positive regulation of immune response
C	0050870	biological_process	positive regulation of T cell activation
C	0051289	biological_process	protein homotetramerization
C	0055038	cellular_component	recycling endosome membrane
C	0060586	biological_process	multicellular organismal-level iron ion homeostasis
C	0070062	cellular_component	extracellular exosome
C	0071281	biological_process	cellular response to iron ion
C	0071283	biological_process	cellular response to iron(III) ion
C	0071316	biological_process	cellular response to nicotine
C	1900121	biological_process	negative regulation of receptor binding
C	1900122	biological_process	positive regulation of receptor binding
C	1904434	biological_process	positive regulation of ferrous iron binding
C	1904437	biological_process	positive regulation of transferrin receptor binding
C	1904724	cellular_component	tertiary granule lumen
C	1990000	biological_process	amyloid fibril formation
C	1990712	cellular_component	HFE-transferrin receptor complex
C	2000774	biological_process	positive regulation of cellular senescence
C	2000978	biological_process	negative regulation of forebrain neuron differentiation
D	0000139	cellular_component	Golgi membrane
D	0001913	biological_process	T cell mediated cytotoxicity
D	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
D	0002237	biological_process	response to molecule of bacterial origin
D	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
D	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
D	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
D	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
D	0002726	biological_process	positive regulation of T cell cytokine production
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005765	cellular_component	lysosomal membrane
D	0005783	cellular_component	endoplasmic reticulum
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0007608	biological_process	sensory perception of smell
D	0007611	biological_process	learning or memory
D	0009897	cellular_component	external side of plasma membrane
D	0009986	cellular_component	cell surface
D	0010977	biological_process	negative regulation of neuron projection development
D	0012507	cellular_component	ER to Golgi transport vesicle membrane
D	0016020	cellular_component	membrane
D	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
D	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
D	0023026	molecular_function	MHC class II protein complex binding
D	0030670	cellular_component	phagocytic vesicle membrane
D	0031901	cellular_component	early endosome membrane
D	0031902	cellular_component	late endosome membrane
D	0031905	cellular_component	early endosome lumen
D	0032092	biological_process	positive regulation of protein binding
D	0033077	biological_process	T cell differentiation in thymus
D	0034756	biological_process	regulation of iron ion transport
D	0035580	cellular_component	specific granule lumen
D	0042026	biological_process	protein refolding
D	0042605	molecular_function	peptide antigen binding
D	0042612	cellular_component	MHC class I protein complex
D	0042613	cellular_component	MHC class II protein complex
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042824	cellular_component	MHC class I peptide loading complex
D	0045646	biological_process	regulation of erythrocyte differentiation
D	0048260	biological_process	positive regulation of receptor-mediated endocytosis
D	0050680	biological_process	negative regulation of epithelial cell proliferation
D	0050768	biological_process	negative regulation of neurogenesis
D	0050778	biological_process	positive regulation of immune response
D	0050870	biological_process	positive regulation of T cell activation
D	0051289	biological_process	protein homotetramerization
D	0055038	cellular_component	recycling endosome membrane
D	0060586	biological_process	multicellular organismal-level iron ion homeostasis
D	0070062	cellular_component	extracellular exosome
D	0071281	biological_process	cellular response to iron ion
D	0071283	biological_process	cellular response to iron(III) ion
D	0071316	biological_process	cellular response to nicotine
D	1900121	biological_process	negative regulation of receptor binding
D	1900122	biological_process	positive regulation of receptor binding
D	1904434	biological_process	positive regulation of ferrous iron binding
D	1904437	biological_process	positive regulation of transferrin receptor binding
D	1904724	cellular_component	tertiary granule lumen
D	1990000	biological_process	amyloid fibril formation
D	1990712	cellular_component	HFE-transferrin receptor complex
D	2000774	biological_process	positive regulation of cellular senescence
D	2000978	biological_process	negative regulation of forebrain neuron differentiation
E	0000139	cellular_component	Golgi membrane
E	0001913	biological_process	T cell mediated cytotoxicity
E	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
E	0002237	biological_process	response to molecule of bacterial origin
E	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
E	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
E	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
E	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
E	0002726	biological_process	positive regulation of T cell cytokine production
E	0005198	molecular_function	structural molecule activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005765	cellular_component	lysosomal membrane
E	0005783	cellular_component	endoplasmic reticulum
E	0005788	cellular_component	endoplasmic reticulum lumen
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005925	cellular_component	focal adhesion
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006955	biological_process	immune response
E	0007608	biological_process	sensory perception of smell
E	0007611	biological_process	learning or memory
E	0009897	cellular_component	external side of plasma membrane
E	0009986	cellular_component	cell surface
E	0010977	biological_process	negative regulation of neuron projection development
E	0012507	cellular_component	ER to Golgi transport vesicle membrane
E	0016020	cellular_component	membrane
E	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
E	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
E	0023026	molecular_function	MHC class II protein complex binding
E	0030670	cellular_component	phagocytic vesicle membrane
E	0031901	cellular_component	early endosome membrane
E	0031902	cellular_component	late endosome membrane
E	0031905	cellular_component	early endosome lumen
E	0032092	biological_process	positive regulation of protein binding
E	0033077	biological_process	T cell differentiation in thymus
E	0034756	biological_process	regulation of iron ion transport
E	0035580	cellular_component	specific granule lumen
E	0042026	biological_process	protein refolding
E	0042605	molecular_function	peptide antigen binding
E	0042612	cellular_component	MHC class I protein complex
E	0042613	cellular_component	MHC class II protein complex
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0042824	cellular_component	MHC class I peptide loading complex
E	0045646	biological_process	regulation of erythrocyte differentiation
E	0048260	biological_process	positive regulation of receptor-mediated endocytosis
E	0050680	biological_process	negative regulation of epithelial cell proliferation
E	0050768	biological_process	negative regulation of neurogenesis
E	0050778	biological_process	positive regulation of immune response
E	0050870	biological_process	positive regulation of T cell activation
E	0051289	biological_process	protein homotetramerization
E	0055038	cellular_component	recycling endosome membrane
E	0060586	biological_process	multicellular organismal-level iron ion homeostasis
E	0070062	cellular_component	extracellular exosome
E	0071281	biological_process	cellular response to iron ion
E	0071283	biological_process	cellular response to iron(III) ion
E	0071316	biological_process	cellular response to nicotine
E	1900121	biological_process	negative regulation of receptor binding
E	1900122	biological_process	positive regulation of receptor binding
E	1904434	biological_process	positive regulation of ferrous iron binding
E	1904437	biological_process	positive regulation of transferrin receptor binding
E	1904724	cellular_component	tertiary granule lumen
E	1990000	biological_process	amyloid fibril formation
E	1990712	cellular_component	HFE-transferrin receptor complex
E	2000774	biological_process	positive regulation of cellular senescence
E	2000978	biological_process	negative regulation of forebrain neuron differentiation
F	0000139	cellular_component	Golgi membrane
F	0001913	biological_process	T cell mediated cytotoxicity
F	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
F	0002237	biological_process	response to molecule of bacterial origin
F	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
F	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
F	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
F	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
F	0002726	biological_process	positive regulation of T cell cytokine production
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005765	cellular_component	lysosomal membrane
F	0005783	cellular_component	endoplasmic reticulum
F	0005788	cellular_component	endoplasmic reticulum lumen
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005925	cellular_component	focal adhesion
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006955	biological_process	immune response
F	0007608	biological_process	sensory perception of smell
F	0007611	biological_process	learning or memory
F	0009897	cellular_component	external side of plasma membrane
F	0009986	cellular_component	cell surface
F	0010977	biological_process	negative regulation of neuron projection development
F	0012507	cellular_component	ER to Golgi transport vesicle membrane
F	0016020	cellular_component	membrane
F	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
F	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
F	0023026	molecular_function	MHC class II protein complex binding
F	0030670	cellular_component	phagocytic vesicle membrane
F	0031901	cellular_component	early endosome membrane
F	0031902	cellular_component	late endosome membrane
F	0031905	cellular_component	early endosome lumen
F	0032092	biological_process	positive regulation of protein binding
F	0033077	biological_process	T cell differentiation in thymus
F	0034756	biological_process	regulation of iron ion transport
F	0035580	cellular_component	specific granule lumen
F	0042026	biological_process	protein refolding
F	0042605	molecular_function	peptide antigen binding
F	0042612	cellular_component	MHC class I protein complex
F	0042613	cellular_component	MHC class II protein complex
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0042824	cellular_component	MHC class I peptide loading complex
F	0045646	biological_process	regulation of erythrocyte differentiation
F	0048260	biological_process	positive regulation of receptor-mediated endocytosis
F	0050680	biological_process	negative regulation of epithelial cell proliferation
F	0050768	biological_process	negative regulation of neurogenesis
F	0050778	biological_process	positive regulation of immune response
F	0050870	biological_process	positive regulation of T cell activation
F	0051289	biological_process	protein homotetramerization
F	0055038	cellular_component	recycling endosome membrane
F	0060586	biological_process	multicellular organismal-level iron ion homeostasis
F	0070062	cellular_component	extracellular exosome
F	0071281	biological_process	cellular response to iron ion
F	0071283	biological_process	cellular response to iron(III) ion
F	0071316	biological_process	cellular response to nicotine
F	1900121	biological_process	negative regulation of receptor binding
F	1900122	biological_process	positive regulation of receptor binding
F	1904434	biological_process	positive regulation of ferrous iron binding
F	1904437	biological_process	positive regulation of transferrin receptor binding
F	1904724	cellular_component	tertiary granule lumen
F	1990000	biological_process	amyloid fibril formation
F	1990712	cellular_component	HFE-transferrin receptor complex
F	2000774	biological_process	positive regulation of cellular senescence
F	2000978	biological_process	negative regulation of forebrain neuron differentiation
G	0000139	cellular_component	Golgi membrane
G	0001913	biological_process	T cell mediated cytotoxicity
G	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
G	0002237	biological_process	response to molecule of bacterial origin
G	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
G	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
G	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
G	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
G	0002726	biological_process	positive regulation of T cell cytokine production
G	0005198	molecular_function	structural molecule activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005765	cellular_component	lysosomal membrane
G	0005783	cellular_component	endoplasmic reticulum
G	0005788	cellular_component	endoplasmic reticulum lumen
G	0005794	cellular_component	Golgi apparatus
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0005925	cellular_component	focal adhesion
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006955	biological_process	immune response
G	0007608	biological_process	sensory perception of smell
G	0007611	biological_process	learning or memory
G	0009897	cellular_component	external side of plasma membrane
G	0009986	cellular_component	cell surface
G	0010977	biological_process	negative regulation of neuron projection development
G	0012507	cellular_component	ER to Golgi transport vesicle membrane
G	0016020	cellular_component	membrane
G	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
G	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
G	0023026	molecular_function	MHC class II protein complex binding
G	0030670	cellular_component	phagocytic vesicle membrane
G	0031901	cellular_component	early endosome membrane
G	0031902	cellular_component	late endosome membrane
G	0031905	cellular_component	early endosome lumen
G	0032092	biological_process	positive regulation of protein binding
G	0033077	biological_process	T cell differentiation in thymus
G	0034756	biological_process	regulation of iron ion transport
G	0035580	cellular_component	specific granule lumen
G	0042026	biological_process	protein refolding
G	0042605	molecular_function	peptide antigen binding
G	0042612	cellular_component	MHC class I protein complex
G	0042613	cellular_component	MHC class II protein complex
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0042824	cellular_component	MHC class I peptide loading complex
G	0045646	biological_process	regulation of erythrocyte differentiation
G	0048260	biological_process	positive regulation of receptor-mediated endocytosis
G	0050680	biological_process	negative regulation of epithelial cell proliferation
G	0050768	biological_process	negative regulation of neurogenesis
G	0050778	biological_process	positive regulation of immune response
G	0050870	biological_process	positive regulation of T cell activation
G	0051289	biological_process	protein homotetramerization
G	0055038	cellular_component	recycling endosome membrane
G	0060586	biological_process	multicellular organismal-level iron ion homeostasis
G	0070062	cellular_component	extracellular exosome
G	0071281	biological_process	cellular response to iron ion
G	0071283	biological_process	cellular response to iron(III) ion
G	0071316	biological_process	cellular response to nicotine
G	1900121	biological_process	negative regulation of receptor binding
G	1900122	biological_process	positive regulation of receptor binding
G	1904434	biological_process	positive regulation of ferrous iron binding
G	1904437	biological_process	positive regulation of transferrin receptor binding
G	1904724	cellular_component	tertiary granule lumen
G	1990000	biological_process	amyloid fibril formation
G	1990712	cellular_component	HFE-transferrin receptor complex
G	2000774	biological_process	positive regulation of cellular senescence
G	2000978	biological_process	negative regulation of forebrain neuron differentiation
H	0000139	cellular_component	Golgi membrane
H	0001913	biological_process	T cell mediated cytotoxicity
H	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
H	0002237	biological_process	response to molecule of bacterial origin
H	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
H	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
H	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
H	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
H	0002726	biological_process	positive regulation of T cell cytokine production
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005765	cellular_component	lysosomal membrane
H	0005783	cellular_component	endoplasmic reticulum
H	0005788	cellular_component	endoplasmic reticulum lumen
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006955	biological_process	immune response
H	0007608	biological_process	sensory perception of smell
H	0007611	biological_process	learning or memory
H	0009897	cellular_component	external side of plasma membrane
H	0009986	cellular_component	cell surface
H	0010977	biological_process	negative regulation of neuron projection development
H	0012507	cellular_component	ER to Golgi transport vesicle membrane
H	0016020	cellular_component	membrane
H	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
H	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
H	0023026	molecular_function	MHC class II protein complex binding
H	0030670	cellular_component	phagocytic vesicle membrane
H	0031901	cellular_component	early endosome membrane
H	0031902	cellular_component	late endosome membrane
H	0031905	cellular_component	early endosome lumen
H	0032092	biological_process	positive regulation of protein binding
H	0033077	biological_process	T cell differentiation in thymus
H	0034756	biological_process	regulation of iron ion transport
H	0035580	cellular_component	specific granule lumen
H	0042026	biological_process	protein refolding
H	0042605	molecular_function	peptide antigen binding
H	0042612	cellular_component	MHC class I protein complex
H	0042613	cellular_component	MHC class II protein complex
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0042824	cellular_component	MHC class I peptide loading complex
H	0045646	biological_process	regulation of erythrocyte differentiation
H	0048260	biological_process	positive regulation of receptor-mediated endocytosis
H	0050680	biological_process	negative regulation of epithelial cell proliferation
H	0050768	biological_process	negative regulation of neurogenesis
H	0050778	biological_process	positive regulation of immune response
H	0050870	biological_process	positive regulation of T cell activation
H	0051289	biological_process	protein homotetramerization
H	0055038	cellular_component	recycling endosome membrane
H	0060586	biological_process	multicellular organismal-level iron ion homeostasis
H	0070062	cellular_component	extracellular exosome
H	0071281	biological_process	cellular response to iron ion
H	0071283	biological_process	cellular response to iron(III) ion
H	0071316	biological_process	cellular response to nicotine
H	1900121	biological_process	negative regulation of receptor binding
H	1900122	biological_process	positive regulation of receptor binding
H	1904434	biological_process	positive regulation of ferrous iron binding
H	1904437	biological_process	positive regulation of transferrin receptor binding
H	1904724	cellular_component	tertiary granule lumen
H	1990000	biological_process	amyloid fibril formation
H	1990712	cellular_component	HFE-transferrin receptor complex
H	2000774	biological_process	positive regulation of cellular senescence
H	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG A 201

Chain	Residue
A	TYR10

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG B 200

Chain	Residue
A	ASP53
B	SER52
B	SER55
B	TYR67
C	ASP53

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 B 100

Chain	Residue
D	LYS58
B	ARG12
B	HIS13
D	SER57

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 C 100

Chain	Residue
A	HIS13
C	SER57
C	LYS58

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 C 101

Chain	Residue
A	SER57
A	LYS58
C	ARG12
C	HIS13
C	PHE22
C	HOH108

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG D 200

Chain	Residue
D	ARG12

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 E 100

Chain	Residue
E	ARG12
E	HIS13
H	SER57
H	LYS58

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 F 100

Chain	Residue
F	ARG12
F	HIS13
G	SER57
G	LYS58

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG G 200

Chain	Residue
E	TYR67
F	ASP53
G	ASP53
G	HOH109

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG G 100

Chain	Residue
F	SER55
F	TYR63
G	ARG12

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 H 100

Chain	Residue
E	SER57
E	LYS58
H	ARG12
H	HIS13

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
A	TYR78-HIS84

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280

Chain	Residue	Details
A	GLN2
B	GLN2
C	GLN2
D	GLN2
E	GLN2
F	GLN2
G	GLN2
H	GLN2

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443

Chain	Residue	Details
A	ILE1
B	ILE1
C	ILE1
D	ILE1
E	ILE1
F	ILE1
G	ILE1
H	ILE1

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443

Chain	Residue	Details
A	LYS19
B	LYS58
B	LYS91
B	LYS94
C	LYS19
C	LYS41
C	LYS48
C	LYS58
C	LYS91
C	LYS94
D	LYS19
A	LYS41
D	LYS41
D	LYS48
D	LYS58
D	LYS91
D	LYS94
E	LYS19
E	LYS41
E	LYS48
E	LYS58
E	LYS91
A	LYS48
E	LYS94
F	LYS19
F	LYS41
F	LYS48
F	LYS58
F	LYS91
F	LYS94
G	LYS19
G	LYS41
G	LYS48
A	LYS58
G	LYS58
G	LYS91
G	LYS94
H	LYS19
H	LYS41
H	LYS48
H	LYS58
H	LYS91
H	LYS94
A	LYS91
A	LYS94
B	LYS19
B	LYS41
B	LYS48

---