3TKS

Crystal structure of full-length human peroxiredoxin 4 in three different redox states

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0007252	biological_process	I-kappaB phosphorylation
A	0007283	biological_process	spermatogenesis
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0008584	biological_process	male gonad development
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0022417	biological_process	protein maturation by protein folding
A	0030198	biological_process	extracellular matrix organization
A	0034774	cellular_component	secretory granule lumen
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0042802	molecular_function	identical protein binding
A	0045454	biological_process	cell redox homeostasis
A	0051920	molecular_function	peroxiredoxin activity
A	0060090	molecular_function	molecular adaptor activity
A	0070062	cellular_component	extracellular exosome
A	0072593	biological_process	reactive oxygen species metabolic process
A	0098869	biological_process	cellular oxidant detoxification
A	0140313	molecular_function	molecular sequestering activity
A	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2000255	biological_process	negative regulation of male germ cell proliferation
B	0004601	molecular_function	peroxidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0007252	biological_process	I-kappaB phosphorylation
B	0007283	biological_process	spermatogenesis
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0008584	biological_process	male gonad development
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0022417	biological_process	protein maturation by protein folding
B	0030198	biological_process	extracellular matrix organization
B	0034774	cellular_component	secretory granule lumen
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0042802	molecular_function	identical protein binding
B	0045454	biological_process	cell redox homeostasis
B	0051920	molecular_function	peroxiredoxin activity
B	0060090	molecular_function	molecular adaptor activity
B	0070062	cellular_component	extracellular exosome
B	0072593	biological_process	reactive oxygen species metabolic process
B	0098869	biological_process	cellular oxidant detoxification
B	0140313	molecular_function	molecular sequestering activity
B	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	2000255	biological_process	negative regulation of male germ cell proliferation
C	0004601	molecular_function	peroxidase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005829	cellular_component	cytosol
C	0006979	biological_process	response to oxidative stress
C	0007252	biological_process	I-kappaB phosphorylation
C	0007283	biological_process	spermatogenesis
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0008584	biological_process	male gonad development
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0022417	biological_process	protein maturation by protein folding
C	0030198	biological_process	extracellular matrix organization
C	0034774	cellular_component	secretory granule lumen
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0042802	molecular_function	identical protein binding
C	0045454	biological_process	cell redox homeostasis
C	0051920	molecular_function	peroxiredoxin activity
C	0060090	molecular_function	molecular adaptor activity
C	0070062	cellular_component	extracellular exosome
C	0072593	biological_process	reactive oxygen species metabolic process
C	0098869	biological_process	cellular oxidant detoxification
C	0140313	molecular_function	molecular sequestering activity
C	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
C	1904813	cellular_component	ficolin-1-rich granule lumen
C	2000255	biological_process	negative regulation of male germ cell proliferation
D	0004601	molecular_function	peroxidase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005829	cellular_component	cytosol
D	0006979	biological_process	response to oxidative stress
D	0007252	biological_process	I-kappaB phosphorylation
D	0007283	biological_process	spermatogenesis
D	0008379	molecular_function	thioredoxin peroxidase activity
D	0008584	biological_process	male gonad development
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0022417	biological_process	protein maturation by protein folding
D	0030198	biological_process	extracellular matrix organization
D	0034774	cellular_component	secretory granule lumen
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0042802	molecular_function	identical protein binding
D	0045454	biological_process	cell redox homeostasis
D	0051920	molecular_function	peroxiredoxin activity
D	0060090	molecular_function	molecular adaptor activity
D	0070062	cellular_component	extracellular exosome
D	0072593	biological_process	reactive oxygen species metabolic process
D	0098869	biological_process	cellular oxidant detoxification
D	0140313	molecular_function	molecular sequestering activity
D	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
D	1904813	cellular_component	ficolin-1-rich granule lumen
D	2000255	biological_process	negative regulation of male germ cell proliferation
E	0004601	molecular_function	peroxidase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005829	cellular_component	cytosol
E	0006979	biological_process	response to oxidative stress
E	0007252	biological_process	I-kappaB phosphorylation
E	0007283	biological_process	spermatogenesis
E	0008379	molecular_function	thioredoxin peroxidase activity
E	0008584	biological_process	male gonad development
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0022417	biological_process	protein maturation by protein folding
E	0030198	biological_process	extracellular matrix organization
E	0034774	cellular_component	secretory granule lumen
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0042802	molecular_function	identical protein binding
E	0045454	biological_process	cell redox homeostasis
E	0051920	molecular_function	peroxiredoxin activity
E	0060090	molecular_function	molecular adaptor activity
E	0070062	cellular_component	extracellular exosome
E	0072593	biological_process	reactive oxygen species metabolic process
E	0098869	biological_process	cellular oxidant detoxification
E	0140313	molecular_function	molecular sequestering activity
E	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
E	1904813	cellular_component	ficolin-1-rich granule lumen
E	2000255	biological_process	negative regulation of male germ cell proliferation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PER A 235

Chain	Residue
A	ARG163
A	LEU182
A	HOH281
A	HOH282
A	HOH304

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PER C 235

Chain	Residue
C	HOH374
C	PHE85
C	VAL86
C	CSD87
C	ARG163

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PER D 235

Chain	Residue
D	PHE85
D	VAL86
D	CSD87
D	ARG163
D	HOH241

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000305|PubMed:12059788, ECO:0000305|PubMed:21916849

Chain	Residue	Details
E	CYS87
D	CSD87

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