3TKR

Crystal structure of full-length human peroxiredoxin 4 with T118E mutation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0007252	biological_process	I-kappaB phosphorylation
A	0007283	biological_process	spermatogenesis
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0008584	biological_process	male gonad development
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0030198	biological_process	extracellular matrix organization
A	0034774	cellular_component	secretory granule lumen
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0042802	molecular_function	identical protein binding
A	0045454	biological_process	cell redox homeostasis
A	0051604	biological_process	protein maturation
A	0051920	molecular_function	peroxiredoxin activity
A	0060090	molecular_function	molecular adaptor activity
A	0070062	cellular_component	extracellular exosome
A	0072593	biological_process	reactive oxygen species metabolic process
A	0098869	biological_process	cellular oxidant detoxification
A	0140313	molecular_function	molecular sequestering activity
A	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2000255	biological_process	negative regulation of male germ cell proliferation
B	0004601	molecular_function	peroxidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0007252	biological_process	I-kappaB phosphorylation
B	0007283	biological_process	spermatogenesis
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0008584	biological_process	male gonad development
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0030198	biological_process	extracellular matrix organization
B	0034774	cellular_component	secretory granule lumen
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0042802	molecular_function	identical protein binding
B	0045454	biological_process	cell redox homeostasis
B	0051604	biological_process	protein maturation
B	0051920	molecular_function	peroxiredoxin activity
B	0060090	molecular_function	molecular adaptor activity
B	0070062	cellular_component	extracellular exosome
B	0072593	biological_process	reactive oxygen species metabolic process
B	0098869	biological_process	cellular oxidant detoxification
B	0140313	molecular_function	molecular sequestering activity
B	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	2000255	biological_process	negative regulation of male germ cell proliferation
C	0004601	molecular_function	peroxidase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005829	cellular_component	cytosol
C	0006979	biological_process	response to oxidative stress
C	0007252	biological_process	I-kappaB phosphorylation
C	0007283	biological_process	spermatogenesis
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0008584	biological_process	male gonad development
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0030198	biological_process	extracellular matrix organization
C	0034774	cellular_component	secretory granule lumen
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0042802	molecular_function	identical protein binding
C	0045454	biological_process	cell redox homeostasis
C	0051604	biological_process	protein maturation
C	0051920	molecular_function	peroxiredoxin activity
C	0060090	molecular_function	molecular adaptor activity
C	0070062	cellular_component	extracellular exosome
C	0072593	biological_process	reactive oxygen species metabolic process
C	0098869	biological_process	cellular oxidant detoxification
C	0140313	molecular_function	molecular sequestering activity
C	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
C	1904813	cellular_component	ficolin-1-rich granule lumen
C	2000255	biological_process	negative regulation of male germ cell proliferation
D	0004601	molecular_function	peroxidase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005829	cellular_component	cytosol
D	0006979	biological_process	response to oxidative stress
D	0007252	biological_process	I-kappaB phosphorylation
D	0007283	biological_process	spermatogenesis
D	0008379	molecular_function	thioredoxin peroxidase activity
D	0008584	biological_process	male gonad development
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0030198	biological_process	extracellular matrix organization
D	0034774	cellular_component	secretory granule lumen
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0042802	molecular_function	identical protein binding
D	0045454	biological_process	cell redox homeostasis
D	0051604	biological_process	protein maturation
D	0051920	molecular_function	peroxiredoxin activity
D	0060090	molecular_function	molecular adaptor activity
D	0070062	cellular_component	extracellular exosome
D	0072593	biological_process	reactive oxygen species metabolic process
D	0098869	biological_process	cellular oxidant detoxification
D	0140313	molecular_function	molecular sequestering activity
D	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
D	1904813	cellular_component	ficolin-1-rich granule lumen
D	2000255	biological_process	negative regulation of male germ cell proliferation
E	0004601	molecular_function	peroxidase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005829	cellular_component	cytosol
E	0006979	biological_process	response to oxidative stress
E	0007252	biological_process	I-kappaB phosphorylation
E	0007283	biological_process	spermatogenesis
E	0008379	molecular_function	thioredoxin peroxidase activity
E	0008584	biological_process	male gonad development
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0030198	biological_process	extracellular matrix organization
E	0034774	cellular_component	secretory granule lumen
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0042802	molecular_function	identical protein binding
E	0045454	biological_process	cell redox homeostasis
E	0051604	biological_process	protein maturation
E	0051920	molecular_function	peroxiredoxin activity
E	0060090	molecular_function	molecular adaptor activity
E	0070062	cellular_component	extracellular exosome
E	0072593	biological_process	reactive oxygen species metabolic process
E	0098869	biological_process	cellular oxidant detoxification
E	0140313	molecular_function	molecular sequestering activity
E	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
E	1904813	cellular_component	ficolin-1-rich granule lumen
E	2000255	biological_process	negative regulation of male germ cell proliferation
F	0004601	molecular_function	peroxidase activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005783	cellular_component	endoplasmic reticulum
F	0005829	cellular_component	cytosol
F	0006979	biological_process	response to oxidative stress
F	0007252	biological_process	I-kappaB phosphorylation
F	0007283	biological_process	spermatogenesis
F	0008379	molecular_function	thioredoxin peroxidase activity
F	0008584	biological_process	male gonad development
F	0016209	molecular_function	antioxidant activity
F	0016491	molecular_function	oxidoreductase activity
F	0030198	biological_process	extracellular matrix organization
F	0034774	cellular_component	secretory granule lumen
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0042802	molecular_function	identical protein binding
F	0045454	biological_process	cell redox homeostasis
F	0051604	biological_process	protein maturation
F	0051920	molecular_function	peroxiredoxin activity
F	0060090	molecular_function	molecular adaptor activity
F	0070062	cellular_component	extracellular exosome
F	0072593	biological_process	reactive oxygen species metabolic process
F	0098869	biological_process	cellular oxidant detoxification
F	0140313	molecular_function	molecular sequestering activity
F	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
F	1904813	cellular_component	ficolin-1-rich granule lumen
F	2000255	biological_process	negative regulation of male germ cell proliferation
G	0004601	molecular_function	peroxidase activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005783	cellular_component	endoplasmic reticulum
G	0005829	cellular_component	cytosol
G	0006979	biological_process	response to oxidative stress
G	0007252	biological_process	I-kappaB phosphorylation
G	0007283	biological_process	spermatogenesis
G	0008379	molecular_function	thioredoxin peroxidase activity
G	0008584	biological_process	male gonad development
G	0016209	molecular_function	antioxidant activity
G	0016491	molecular_function	oxidoreductase activity
G	0030198	biological_process	extracellular matrix organization
G	0034774	cellular_component	secretory granule lumen
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0042802	molecular_function	identical protein binding
G	0045454	biological_process	cell redox homeostasis
G	0051604	biological_process	protein maturation
G	0051920	molecular_function	peroxiredoxin activity
G	0060090	molecular_function	molecular adaptor activity
G	0070062	cellular_component	extracellular exosome
G	0072593	biological_process	reactive oxygen species metabolic process
G	0098869	biological_process	cellular oxidant detoxification
G	0140313	molecular_function	molecular sequestering activity
G	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
G	1904813	cellular_component	ficolin-1-rich granule lumen
G	2000255	biological_process	negative regulation of male germ cell proliferation
H	0004601	molecular_function	peroxidase activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005783	cellular_component	endoplasmic reticulum
H	0005829	cellular_component	cytosol
H	0006979	biological_process	response to oxidative stress
H	0007252	biological_process	I-kappaB phosphorylation
H	0007283	biological_process	spermatogenesis
H	0008379	molecular_function	thioredoxin peroxidase activity
H	0008584	biological_process	male gonad development
H	0016209	molecular_function	antioxidant activity
H	0016491	molecular_function	oxidoreductase activity
H	0030198	biological_process	extracellular matrix organization
H	0034774	cellular_component	secretory granule lumen
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0042802	molecular_function	identical protein binding
H	0045454	biological_process	cell redox homeostasis
H	0051604	biological_process	protein maturation
H	0051920	molecular_function	peroxiredoxin activity
H	0060090	molecular_function	molecular adaptor activity
H	0070062	cellular_component	extracellular exosome
H	0072593	biological_process	reactive oxygen species metabolic process
H	0098869	biological_process	cellular oxidant detoxification
H	0140313	molecular_function	molecular sequestering activity
H	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
H	1904813	cellular_component	ficolin-1-rich granule lumen
H	2000255	biological_process	negative regulation of male germ cell proliferation
I	0004601	molecular_function	peroxidase activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005783	cellular_component	endoplasmic reticulum
I	0005829	cellular_component	cytosol
I	0006979	biological_process	response to oxidative stress
I	0007252	biological_process	I-kappaB phosphorylation
I	0007283	biological_process	spermatogenesis
I	0008379	molecular_function	thioredoxin peroxidase activity
I	0008584	biological_process	male gonad development
I	0016209	molecular_function	antioxidant activity
I	0016491	molecular_function	oxidoreductase activity
I	0030198	biological_process	extracellular matrix organization
I	0034774	cellular_component	secretory granule lumen
I	0042744	biological_process	hydrogen peroxide catabolic process
I	0042802	molecular_function	identical protein binding
I	0045454	biological_process	cell redox homeostasis
I	0051604	biological_process	protein maturation
I	0051920	molecular_function	peroxiredoxin activity
I	0060090	molecular_function	molecular adaptor activity
I	0070062	cellular_component	extracellular exosome
I	0072593	biological_process	reactive oxygen species metabolic process
I	0098869	biological_process	cellular oxidant detoxification
I	0140313	molecular_function	molecular sequestering activity
I	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
I	1904813	cellular_component	ficolin-1-rich granule lumen
I	2000255	biological_process	negative regulation of male germ cell proliferation
J	0004601	molecular_function	peroxidase activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005783	cellular_component	endoplasmic reticulum
J	0005829	cellular_component	cytosol
J	0006979	biological_process	response to oxidative stress
J	0007252	biological_process	I-kappaB phosphorylation
J	0007283	biological_process	spermatogenesis
J	0008379	molecular_function	thioredoxin peroxidase activity
J	0008584	biological_process	male gonad development
J	0016209	molecular_function	antioxidant activity
J	0016491	molecular_function	oxidoreductase activity
J	0030198	biological_process	extracellular matrix organization
J	0034774	cellular_component	secretory granule lumen
J	0042744	biological_process	hydrogen peroxide catabolic process
J	0042802	molecular_function	identical protein binding
J	0045454	biological_process	cell redox homeostasis
J	0051604	biological_process	protein maturation
J	0051920	molecular_function	peroxiredoxin activity
J	0060090	molecular_function	molecular adaptor activity
J	0070062	cellular_component	extracellular exosome
J	0072593	biological_process	reactive oxygen species metabolic process
J	0098869	biological_process	cellular oxidant detoxification
J	0140313	molecular_function	molecular sequestering activity
J	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
J	1904813	cellular_component	ficolin-1-rich granule lumen
J	2000255	biological_process	negative regulation of male germ cell proliferation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1580
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	10
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"PubMed","id":"12059788","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21916849","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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