3THN

Crystal structure of Mre11 core with manganese

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004519	molecular_function	endonuclease activity
A	0006259	biological_process	DNA metabolic process
A	0008408	molecular_function	3'-5' exonuclease activity
A	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 360

Chain	Residue
A	ASP14
A	HIS16
A	ASP58
A	HIS216
A	HIS218

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN A 361

Chain	Residue
A	ASP58
A	ASN93
A	HIS180
A	HIS216

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1

Chain	Residue
A	MET7
A	GLN130
A	LYS255

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 2

Chain	Residue
A	ARG128
A	LYS255

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 3

Chain	Residue
A	LEU186
A	LEU186
A	ARG202
A	ARG202
A	ARG221
A	ARG221

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q8U1N9, ECO:0000255|HAMAP-Rule:MF_02044

Chain	Residue	Details
A	GLN94

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:3THN, ECO:0007744|PDB:3THO, ECO:0007744|PDB:4NZV, ECO:0007744|PDB:4O24, ECO:0007744|PDB:4O43, ECO:0007744|PDB:4O4K, ECO:0007744|PDB:4O5G

Chain	Residue	Details
A	ASP14
A	HIS16
A	ASP58
A	HIS216

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:3THN, ECO:0007744|PDB:3THO, ECO:0007744|PDB:4NZV, ECO:0007744|PDB:4O24, ECO:0007744|PDB:4O4K

Chain	Residue	Details
A	HIS180

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:4NZV

Chain	Residue	Details
A	HIS218

---