3THN

Crystal structure of Mre11 core with manganese

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004519	molecular_function	endonuclease activity
A	0006259	biological_process	DNA metabolic process
A	0008408	molecular_function	3'-5' exonuclease activity
A	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 360

Chain	Residue
A	ASP14
A	HIS16
A	ASP58
A	HIS216
A	HIS218

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN A 361

Chain	Residue
A	ASP58
A	ASN93
A	HIS180
A	HIS216

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1

Chain	Residue
A	MET7
A	GLN130
A	LYS255

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 2

Chain	Residue
A	ARG128
A	LYS255

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 3

Chain	Residue
A	LEU186
A	LEU186
A	ARG202
A	ARG202
A	ARG221
A	ARG221

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q8U1N9","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_02044","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24316220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3THN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NZV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O24","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O43","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O5G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24316220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3THN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NZV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O24","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O4K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24316220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NZV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---