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3TF2

Crystal structure of the cap free human translation initiation factor eIF4E

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000339molecular_functionRNA cap binding
A0000340molecular_functionRNA 7-methylguanosine cap binding
A0000932cellular_componentP-body
A0001662biological_processbehavioral fear response
A0003723molecular_functionRNA binding
A0003743molecular_functiontranslation initiation factor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006406biological_processmRNA export from nucleus
A0006412biological_processtranslation
A0006413biological_processtranslational initiation
A0006417biological_processregulation of translation
A0010494cellular_componentcytoplasmic stress granule
A0010507biological_processnegative regulation of autophagy
A0016281cellular_componenteukaryotic translation initiation factor 4F complex
A0016442cellular_componentRISC complex
A0016604cellular_componentnuclear body
A0016607cellular_componentnuclear speck
A0017148biological_processnegative regulation of translation
A0019827biological_processstem cell population maintenance
A0019899molecular_functionenzyme binding
A0030182biological_processneuron differentiation
A0031370molecular_functioneukaryotic initiation factor 4G binding
A0033391cellular_componentchromatoid body
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0045665biological_processnegative regulation of neuron differentiation
A0045931biological_processpositive regulation of mitotic cell cycle
A0048471cellular_componentperinuclear region of cytoplasm
A0051028biological_processmRNA transport
A0051168biological_processnuclear export
A0070062cellular_componentextracellular exosome
A0071549biological_processcellular response to dexamethasone stimulus
A0098794cellular_componentpostsynapse
A0098808molecular_functionmRNA cap binding
A0098978cellular_componentglutamatergic synapse
A0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
A0140297molecular_functionDNA-binding transcription factor binding
B0000082biological_processG1/S transition of mitotic cell cycle
B0000339molecular_functionRNA cap binding
B0000340molecular_functionRNA 7-methylguanosine cap binding
B0000932cellular_componentP-body
B0001662biological_processbehavioral fear response
B0003723molecular_functionRNA binding
B0003743molecular_functiontranslation initiation factor activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006406biological_processmRNA export from nucleus
B0006412biological_processtranslation
B0006413biological_processtranslational initiation
B0006417biological_processregulation of translation
B0010494cellular_componentcytoplasmic stress granule
B0010507biological_processnegative regulation of autophagy
B0016281cellular_componenteukaryotic translation initiation factor 4F complex
B0016442cellular_componentRISC complex
B0016604cellular_componentnuclear body
B0016607cellular_componentnuclear speck
B0017148biological_processnegative regulation of translation
B0019827biological_processstem cell population maintenance
B0019899molecular_functionenzyme binding
B0030182biological_processneuron differentiation
B0031370molecular_functioneukaryotic initiation factor 4G binding
B0033391cellular_componentchromatoid body
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0045665biological_processnegative regulation of neuron differentiation
B0045931biological_processpositive regulation of mitotic cell cycle
B0048471cellular_componentperinuclear region of cytoplasm
B0051028biological_processmRNA transport
B0051168biological_processnuclear export
B0070062cellular_componentextracellular exosome
B0071549biological_processcellular response to dexamethasone stimulus
B0098794cellular_componentpostsynapse
B0098808molecular_functionmRNA cap binding
B0098978cellular_componentglutamatergic synapse
B0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
B0140297molecular_functionDNA-binding transcription factor binding
C0000082biological_processG1/S transition of mitotic cell cycle
C0000339molecular_functionRNA cap binding
C0000340molecular_functionRNA 7-methylguanosine cap binding
C0000932cellular_componentP-body
C0001662biological_processbehavioral fear response
C0003723molecular_functionRNA binding
C0003743molecular_functiontranslation initiation factor activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006406biological_processmRNA export from nucleus
C0006412biological_processtranslation
C0006413biological_processtranslational initiation
C0006417biological_processregulation of translation
C0010494cellular_componentcytoplasmic stress granule
C0010507biological_processnegative regulation of autophagy
C0016281cellular_componenteukaryotic translation initiation factor 4F complex
C0016442cellular_componentRISC complex
C0016604cellular_componentnuclear body
C0016607cellular_componentnuclear speck
C0017148biological_processnegative regulation of translation
C0019827biological_processstem cell population maintenance
C0019899molecular_functionenzyme binding
C0030182biological_processneuron differentiation
C0031370molecular_functioneukaryotic initiation factor 4G binding
C0033391cellular_componentchromatoid body
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0045665biological_processnegative regulation of neuron differentiation
C0045931biological_processpositive regulation of mitotic cell cycle
C0048471cellular_componentperinuclear region of cytoplasm
C0051028biological_processmRNA transport
C0051168biological_processnuclear export
C0070062cellular_componentextracellular exosome
C0071549biological_processcellular response to dexamethasone stimulus
C0098794cellular_componentpostsynapse
C0098808molecular_functionmRNA cap binding
C0098978cellular_componentglutamatergic synapse
C0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
C0140297molecular_functionDNA-binding transcription factor binding
D0000082biological_processG1/S transition of mitotic cell cycle
D0000339molecular_functionRNA cap binding
D0000340molecular_functionRNA 7-methylguanosine cap binding
D0000932cellular_componentP-body
D0001662biological_processbehavioral fear response
D0003723molecular_functionRNA binding
D0003743molecular_functiontranslation initiation factor activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006406biological_processmRNA export from nucleus
D0006412biological_processtranslation
D0006413biological_processtranslational initiation
D0006417biological_processregulation of translation
D0010494cellular_componentcytoplasmic stress granule
D0010507biological_processnegative regulation of autophagy
D0016281cellular_componenteukaryotic translation initiation factor 4F complex
D0016442cellular_componentRISC complex
D0016604cellular_componentnuclear body
D0016607cellular_componentnuclear speck
D0017148biological_processnegative regulation of translation
D0019827biological_processstem cell population maintenance
D0019899molecular_functionenzyme binding
D0030182biological_processneuron differentiation
D0031370molecular_functioneukaryotic initiation factor 4G binding
D0033391cellular_componentchromatoid body
D0036464cellular_componentcytoplasmic ribonucleoprotein granule
D0045665biological_processnegative regulation of neuron differentiation
D0045931biological_processpositive regulation of mitotic cell cycle
D0048471cellular_componentperinuclear region of cytoplasm
D0051028biological_processmRNA transport
D0051168biological_processnuclear export
D0070062cellular_componentextracellular exosome
D0071549biological_processcellular response to dexamethasone stimulus
D0098794cellular_componentpostsynapse
D0098808molecular_functionmRNA cap binding
D0098978cellular_componentglutamatergic synapse
D0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
D0140297molecular_functionDNA-binding transcription factor binding
Functional Information from PROSITE/UniProt
site_idPS00813
Number of Residues24
DetailsIF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW
ChainResidueDetails
AASP90-TRP113

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:11879179, ECO:0000269|PubMed:12975586, ECO:0000269|PubMed:16271312
ChainResidueDetails
ATRP56
CTRP102
CARG157
CTHR205
DTRP56
DTRP102
DARG157
DTHR205
ATRP102
AARG157
ATHR205
BTRP56
BTRP102
BARG157
BTHR205
CTRP56

site_idSWS_FT_FI2
Number of Residues4
DetailsSITE: (Microbial infection) Interaction with potato virus Y VPg => ECO:0000269|PubMed:31712417
ChainResidueDetails
ALYS159
BLYS159
CLYS159
DLYS159

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330
ChainResidueDetails
AALA2
BALA2
CALA2
DALA2

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR22
BTHR22
CTHR22
DTHR22

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKC and MKNK2 => ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:25923732, ECO:0000269|PubMed:7665584, ECO:0000269|PubMed:7782323
ChainResidueDetails
ASER209
BSER209
CSER209
DSER209

218853

PDB entries from 2024-04-24

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