Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3TBV

CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH THE LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (A2G,V3P,Y4A)

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0006968	biological_process	cellular defense response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0010977	biological_process	negative regulation of neuron projection development
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0030670	cellular_component	phagocytic vesicle membrane
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0042026	biological_process	protein refolding
B	0042612	cellular_component	MHC class I protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0051289	biological_process	protein homotetramerization
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
D	0001913	biological_process	T cell mediated cytotoxicity
D	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
D	0002237	biological_process	response to molecule of bacterial origin
D	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
D	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
D	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
D	0002726	biological_process	positive regulation of T cell cytokine production
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0006968	biological_process	cellular defense response
D	0007608	biological_process	sensory perception of smell
D	0007611	biological_process	learning or memory
D	0009897	cellular_component	external side of plasma membrane
D	0010977	biological_process	negative regulation of neuron projection development
D	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
D	0030670	cellular_component	phagocytic vesicle membrane
D	0033077	biological_process	T cell differentiation in thymus
D	0034756	biological_process	regulation of iron ion transport
D	0042026	biological_process	protein refolding
D	0042612	cellular_component	MHC class I protein complex
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042824	cellular_component	MHC class I peptide loading complex
D	0045646	biological_process	regulation of erythrocyte differentiation
D	0048260	biological_process	positive regulation of receptor-mediated endocytosis
D	0050680	biological_process	negative regulation of epithelial cell proliferation
D	0050768	biological_process	negative regulation of neurogenesis
D	0051289	biological_process	protein homotetramerization
D	0060586	biological_process	multicellular organismal-level iron ion homeostasis
D	0071281	biological_process	cellular response to iron ion
D	0071283	biological_process	cellular response to iron(III) ion
D	0071316	biological_process	cellular response to nicotine
D	1990000	biological_process	amyloid fibril formation
D	1990712	cellular_component	HFE-transferrin receptor complex
D	2000774	biological_process	positive regulation of cellular senescence
D	2000978	biological_process	negative regulation of forebrain neuron differentiation
F	0001913	biological_process	T cell mediated cytotoxicity
F	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
F	0002237	biological_process	response to molecule of bacterial origin
F	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
F	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
F	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
F	0002726	biological_process	positive regulation of T cell cytokine production
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006955	biological_process	immune response
F	0006968	biological_process	cellular defense response
F	0007608	biological_process	sensory perception of smell
F	0007611	biological_process	learning or memory
F	0009897	cellular_component	external side of plasma membrane
F	0010977	biological_process	negative regulation of neuron projection development
F	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
F	0030670	cellular_component	phagocytic vesicle membrane
F	0033077	biological_process	T cell differentiation in thymus
F	0034756	biological_process	regulation of iron ion transport
F	0042026	biological_process	protein refolding
F	0042612	cellular_component	MHC class I protein complex
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0042824	cellular_component	MHC class I peptide loading complex
F	0045646	biological_process	regulation of erythrocyte differentiation
F	0048260	biological_process	positive regulation of receptor-mediated endocytosis
F	0050680	biological_process	negative regulation of epithelial cell proliferation
F	0050768	biological_process	negative regulation of neurogenesis
F	0051289	biological_process	protein homotetramerization
F	0060586	biological_process	multicellular organismal-level iron ion homeostasis
F	0071281	biological_process	cellular response to iron ion
F	0071283	biological_process	cellular response to iron(III) ion
F	0071316	biological_process	cellular response to nicotine
F	1990000	biological_process	amyloid fibril formation
F	1990712	cellular_component	HFE-transferrin receptor complex
F	2000774	biological_process	positive regulation of cellular senescence
F	2000978	biological_process	negative regulation of forebrain neuron differentiation
H	0001913	biological_process	T cell mediated cytotoxicity
H	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
H	0002237	biological_process	response to molecule of bacterial origin
H	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
H	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
H	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
H	0002726	biological_process	positive regulation of T cell cytokine production
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006955	biological_process	immune response
H	0006968	biological_process	cellular defense response
H	0007608	biological_process	sensory perception of smell
H	0007611	biological_process	learning or memory
H	0009897	cellular_component	external side of plasma membrane
H	0010977	biological_process	negative regulation of neuron projection development
H	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
H	0030670	cellular_component	phagocytic vesicle membrane
H	0033077	biological_process	T cell differentiation in thymus
H	0034756	biological_process	regulation of iron ion transport
H	0042026	biological_process	protein refolding
H	0042612	cellular_component	MHC class I protein complex
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0042824	cellular_component	MHC class I peptide loading complex
H	0045646	biological_process	regulation of erythrocyte differentiation
H	0048260	biological_process	positive regulation of receptor-mediated endocytosis
H	0050680	biological_process	negative regulation of epithelial cell proliferation
H	0050768	biological_process	negative regulation of neurogenesis
H	0051289	biological_process	protein homotetramerization
H	0060586	biological_process	multicellular organismal-level iron ion homeostasis
H	0071281	biological_process	cellular response to iron ion
H	0071283	biological_process	cellular response to iron(III) ion
H	0071316	biological_process	cellular response to nicotine
H	1990000	biological_process	amyloid fibril formation
H	1990712	cellular_component	HFE-transferrin receptor complex
H	2000774	biological_process	positive regulation of cellular senescence
H	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 339

Chain	Residue
A	PRO15
A	ALA89
A	GLY90
A	GLY91
A	HOH375
A	HOH396
A	HOH479

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 340

Chain	Residue
A	THR10
A	ILE23
A	VAL25
A	TYR27
A	ARG35
B	MET54
B	SER55
B	PHE56
A	PHE8
A	GLU9

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 341

Chain	Residue
A	ARG145
A	GLU148

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 100

Chain	Residue
B	TYR26
B	SER57
B	TYR63
B	HOH645

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 339

Chain	Residue
C	TYR27
C	ASN30
C	HOH396
C	HOH646
C	HOH698
D	HOH235

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 339

Chain	Residue
E	PRO15
E	ALA89
E	GLY90
E	HOH473

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL E 340

Chain	Residue
E	PHE8
E	TYR27
E	ASN30
E	HOH638
F	PHE56
F	TYR63
F	HOH847

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL E 341

Chain	Residue
E	ARG145

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 F 100

Chain	Residue
F	GLN2
F	LYS3
F	THR4

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL H 100

Chain	Residue
G	PHE8
G	TYR27
G	ASN30
H	PHE56
H	TYR63
H	HOH731

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL H 101

Chain	Residue
H	TYR26
H	GLN29
H	SER57
H	TYR63

site_id	BC3
Number of Residues	27
Details	BINDING SITE FOR CHAIN I OF GLYCOPROTEIN G1

Chain	Residue
A	TYR7
A	GLU9
A	ARG62
A	GLU63
A	LYS66
A	GLN70
A	TRP73
A	SER77
A	ASN80
A	TYR84
A	GLN97
A	SER99
A	PHE116
A	THR143
A	TRP147
A	SER150
A	HIS155
A	TYR156
A	TYR159
A	GLU163
A	TRP167
A	TYR171
A	HOH367
I	HOH10
I	HOH246
I	HOH836
I	HOH842

site_id	BC4
Number of Residues	34
Details	BINDING SITE FOR CHAIN J OF GLYCOPROTEIN G1

Chain	Residue
C	TRP147
C	HIS155
C	TYR156
C	TYR159
C	GLU163
C	TRP167
C	TYR171
C	HOH347
C	HOH351
C	HOH399
C	HOH432
J	HOH10
J	HOH86
J	HOH272
J	HOH653
J	HOH768
C	MET5
C	TYR7
C	GLU9
C	TYR59
C	ARG62
C	GLU63
C	LYS66
C	GLN70
C	TRP73
C	SER77
C	ASN80
C	TYR84
C	GLN97
C	SER99
C	PHE116
C	TYR123
C	THR143
C	LYS146

site_id	BC5
Number of Residues	35
Details	BINDING SITE FOR CHAIN K OF GLYCOPROTEIN G1

Chain	Residue
E	TYR7
E	GLU9
E	ARG62
E	GLU63
E	LYS66
E	GLN70
E	TRP73
E	SER77
E	ASN80
E	TYR84
E	LEU95
E	GLN97
E	SER99
E	PHE116
E	TYR123
E	THR143
E	LYS146
E	TRP147
E	HIS155
E	TYR156
E	TYR159
E	GLU163
E	TRP167
E	TYR171
E	HOH352
E	HOH400
E	HOH403
E	HOH670
K	HOH297
K	HOH305
K	HOH480
K	HOH599
K	HOH673
K	HOH747
K	HOH889

site_id	BC6
Number of Residues	26
Details	BINDING SITE FOR CHAIN L OF GLYCOPROTEIN G1

Chain	Residue
G	MET5
G	TYR7
G	GLU9
G	ARG62
G	GLU63
G	LYS66
G	GLN70
G	TRP73
G	SER77
G	ASN80
G	TYR84
G	GLN97
G	SER99
G	PHE116
G	THR143
G	LYS146
G	TRP147
G	HIS155
G	TYR156
G	TYR159
G	GLU163
G	TRP167
G	TYR171
G	HOH772
L	HOH42
L	HOH233

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCRVYH

Chain	Residue	Details
A	TYR257-HIS263
B	TYR78-HIS84

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:3980466, ECO:0000269\|PubMed:7118212

Chain	Residue	Details
A	ASN86
C	ASN86
E	ASN86
G	ASN86

site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305

Chain	Residue	Details
A	ASN176
C	ASN176
E	ASN176
G	ASN176

site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:3980466

Chain	Residue	Details
A	ASN256
C	ASN256
E	ASN256
G	ASN256

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)