3TB8

Crystal structure of full-length myristoylated HIV-1 Nef

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005102	molecular_function	signaling receptor binding
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005576	cellular_component	extracellular region
A	0016020	cellular_component	membrane
A	0017124	molecular_function	SH3 domain binding
A	0019049	biological_process	virus-mediated perturbation of host defense response
A	0019058	biological_process	viral life cycle
A	0019901	molecular_function	protein kinase binding
A	0020002	cellular_component	host cell plasma membrane
A	0031996	molecular_function	thioesterase binding
A	0033644	cellular_component	host cell membrane
A	0033668	biological_process	symbiont-mediated suppression of host apoptosis
A	0039504	biological_process	symbiont-mediated suppression of host adaptive immune response
A	0039505	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
A	0039521	biological_process	suppression by virus of host autophagy
A	0042288	molecular_function	MHC class I protein binding
A	0042609	molecular_function	CD4 receptor binding
A	0044177	cellular_component	host cell Golgi apparatus
A	0044178	cellular_component	host cell Golgi membrane
A	0044423	cellular_component	virion component
A	0045225	biological_process	negative regulation of CD4 production
A	0046776	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
A	0050848	biological_process	regulation of calcium-mediated signaling
A	0051117	molecular_function	ATPase binding
A	0075528	biological_process	perturbation by virus of host immune response

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Might play a role in AP-1 recruitment to the Nef-MHC-I complex => ECO:0000255|HAMAP-Rule:MF_04078

Chain	Residue	Details
A	MET20

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by viral protease => ECO:0000255|HAMAP-Rule:MF_04078

Chain	Residue	Details
A	TRP57

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by host => ECO:0000255|HAMAP-Rule:MF_04078

Chain	Residue	Details
A	SER6

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site_id	SWS_FT_FI4
Number of Residues	1
Details	LIPID: N-myristoyl glycine; by host => ECO:0000255|HAMAP-Rule:MF_04078

Chain	Residue	Details
A	GLY2

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