3T94
Crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) II complexed with 5'-deoxy-5'-methylthioadenosine and sulfate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| A | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| B | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| C | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006166 | biological_process | purine ribonucleoside salvage |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| D | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0006166 | biological_process | purine ribonucleoside salvage |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016757 | molecular_function | glycosyltransferase activity |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| E | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0006166 | biological_process | purine ribonucleoside salvage |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016757 | molecular_function | glycosyltransferase activity |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| F | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE MTA A 901 |
| Chain | Residue |
| A | SER16 |
| A | MET190 |
| A | ASP214 |
| A | ASP216 |
| A | HOH275 |
| A | SO4902 |
| B | HIS130 |
| B | HOH716 |
| A | HIS59 |
| A | PRO67 |
| A | ALA92 |
| A | VAL93 |
| A | GLY94 |
| A | PHE170 |
| A | ILE188 |
| A | GLY189 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 902 |
| Chain | Residue |
| A | GLY15 |
| A | SER16 |
| A | ARG58 |
| A | HIS59 |
| A | SER91 |
| A | ALA92 |
| A | THR191 |
| A | HOH292 |
| A | MTA901 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 A 271 |
| Chain | Residue |
| A | GLN38 |
| A | ARG64 |
| A | HOH905 |
| A | HOH1036 |
| A | HOH1108 |
| C | GLN38 |
| C | ARG64 |
| C | HOH692 |
| C | HOH816 |
| C | HOH1035 |
| C | HOH1060 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE MTA B 901 |
| Chain | Residue |
| B | SER16 |
| B | HIS59 |
| B | PRO67 |
| B | ALA92 |
| B | VAL93 |
| B | GLY94 |
| B | PHE170 |
| B | ILE188 |
| B | GLY189 |
| B | MET190 |
| B | ASP214 |
| B | ASP216 |
| B | HOH277 |
| B | SO4902 |
| C | HIS130 |
| C | HOH285 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 902 |
| Chain | Residue |
| B | GLY15 |
| B | SER16 |
| B | ARG58 |
| B | HIS59 |
| B | SER91 |
| B | ALA92 |
| B | THR191 |
| B | HOH298 |
| B | MTA901 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 271 |
| Chain | Residue |
| B | GLN38 |
| B | GLN38 |
| B | ARG64 |
| B | ARG64 |
| B | HOH281 |
| B | HOH480 |
| B | HOH1053 |
| B | HOH1139 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 272 |
| Chain | Residue |
| B | LEU96 |
| B | ARG97 |
| B | MET98 |
| B | ARG180 |
| B | HOH444 |
| B | HOH664 |
| E | HOH303 |
| E | HOH328 |
| E | HOH796 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE MTA C 901 |
| Chain | Residue |
| A | HIS130 |
| A | HOH713 |
| C | SER16 |
| C | HIS59 |
| C | PRO67 |
| C | ALA92 |
| C | VAL93 |
| C | GLY94 |
| C | PHE170 |
| C | ILE188 |
| C | GLY189 |
| C | MET190 |
| C | ASP214 |
| C | ASP216 |
| C | HOH280 |
| C | SO4902 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 C 902 |
| Chain | Residue |
| C | ALA92 |
| C | THR191 |
| C | HOH299 |
| C | MTA901 |
| C | GLY15 |
| C | SER16 |
| C | ARG58 |
| C | HIS59 |
| C | SER91 |
| site_id | BC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE MTA D 901 |
| Chain | Residue |
| D | SER16 |
| D | HIS59 |
| D | PRO67 |
| D | ALA92 |
| D | VAL93 |
| D | GLY94 |
| D | PHE170 |
| D | ILE188 |
| D | GLY189 |
| D | MET190 |
| D | ASP214 |
| D | ASP216 |
| D | VAL228 |
| D | HOH282 |
| D | SO4902 |
| E | HIS130 |
| E | HOH714 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 D 902 |
| Chain | Residue |
| D | GLY15 |
| D | SER16 |
| D | ARG58 |
| D | HIS59 |
| D | SER91 |
| D | ALA92 |
| D | THR191 |
| D | HOH306 |
| D | MTA901 |
| site_id | BC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 D 271 |
| Chain | Residue |
| D | GLN38 |
| D | ARG64 |
| D | HOH1034 |
| D | HOH1133 |
| D | HOH1239 |
| F | GLN38 |
| F | ARG64 |
| F | HOH759 |
| F | HOH781 |
| F | HOH1058 |
| site_id | BC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE MTA E 901 |
| Chain | Residue |
| E | SER16 |
| E | HIS59 |
| E | PRO67 |
| E | ALA92 |
| E | VAL93 |
| E | GLY94 |
| E | PHE170 |
| E | ILE188 |
| E | GLY189 |
| E | MET190 |
| E | ASP214 |
| E | ASP216 |
| E | VAL228 |
| E | HOH275 |
| E | SO4902 |
| F | HIS130 |
| F | HOH273 |
| site_id | BC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 E 902 |
| Chain | Residue |
| E | GLY15 |
| E | SER16 |
| E | ARG58 |
| E | HIS59 |
| E | SER91 |
| E | ALA92 |
| E | THR191 |
| E | HOH291 |
| E | MTA901 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 E 271 |
| Chain | Residue |
| E | GLN38 |
| E | GLN38 |
| E | ARG64 |
| E | ARG64 |
| E | HOH281 |
| E | HOH457 |
| E | HOH1168 |
| site_id | BC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE MTA F 901 |
| Chain | Residue |
| D | HIS130 |
| D | HOH715 |
| F | SER16 |
| F | HIS59 |
| F | PRO67 |
| F | ALA92 |
| F | VAL93 |
| F | GLY94 |
| F | PHE170 |
| F | ILE188 |
| F | GLY189 |
| F | MET190 |
| F | ASP214 |
| F | ASP216 |
| F | HOH275 |
| F | SO4902 |
| site_id | BC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 F 902 |
| Chain | Residue |
| F | GLY15 |
| F | SER16 |
| F | ARG58 |
| F | HIS59 |
| F | SER91 |
| F | ALA92 |
| F | THR191 |
| F | HOH303 |
| F | MTA901 |
Functional Information from PROSITE/UniProt
| site_id | PS01240 |
| Number of Residues | 41 |
| Details | PNP_MTAP_2 Purine and other phosphorylases family 2 signature. LprhGrgHrIpphkInyrAn.IwAlkelGvrw.VIsvSAvGSL |
| Chain | Residue | Details |
| A | LEU56-LEU96 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01963","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Site: {"description":"Important for substrate specificity","evidences":[{"source":"HAMAP-Rule","id":"MF_01963","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
