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3T78

Crystal Structure of Mycobacterium tuberculosis Indole Glycerol Phosphate Synthase (IGPS) in Complex with 5-Fluoroanthranilate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000162biological_processtryptophan biosynthetic process
A0000287molecular_functionmagnesium ion binding
A0004425molecular_functionindole-3-glycerol-phosphate synthase activity
A0004640molecular_functionphosphoribosylanthranilate isomerase activity
A0005886cellular_componentplasma membrane
A0006568biological_processtryptophan metabolic process
A0009274cellular_componentpeptidoglycan-based cell wall
A0016830molecular_functioncarbon-carbon lyase activity
A0016831molecular_functioncarboxy-lyase activity
A0046391biological_process5-phosphoribose 1-diphosphate metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 5RG A 273
ChainResidue
ALYS59
AMLI274
AACT275
ASER62
APRO63
ASER64
APHE98
APHE121
AARG191
ALEU193
ALEU196

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE MLI A 274
ChainResidue
ALYS59
AARG191
AGLU219
ASER220
AGLY242
AGLU243
A5RG273
AHOH377
AHOH379
AHOH406
AHOH523
AHOH621

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT A 275
ChainResidue
APHE98
ALYS119
APHE121
A5RG273
AHOH491

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT A 276
ChainResidue
ALYS31
APRO74
AASP103
AASP104
AARG157

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT A 277
ChainResidue
AARG200
AGLY221
AARG223
AASP227
AHOH510

Functional Information from PROSITE/UniProt
site_idPS00614
Number of Residues18
DetailsIGPS Indole-3-glycerol phosphate synthase signature. VIaEVKRASPSagalat.I
ChainResidueDetails
AVAL54-ILE71

222624

PDB entries from 2024-07-17

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