Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE UBY A 401 |
| Chain | Residue |
| A | TYR106 |
| A | GLU166 |
| A | ARG203 |
| A | HIS231 |
| A | GOL405 |
| A | DMS406 |
| A | DMS406 |
| A | ZN410 |
| A | HOH795 |
| A | HOH813 |
| A | HOH820 |
| A | ASN112 |
| A | ALA113 |
| A | PHE114 |
| A | TRP115 |
| A | HIS142 |
| A | GLU143 |
| A | HIS146 |
| A | TYR157 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GOL A 402 |
| Chain | Residue |
| A | GLY247 |
| A | GLY248 |
| A | THR249 |
| A | VAL255 |
| A | GLN273 |
| A | TYR274 |
| A | LEU275 |
| A | THR276 |
| A | HOH727 |
| A | HOH758 |
| A | HOH787 |
| A | HOH855 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 403 |
| Chain | Residue |
| A | SER65 |
| A | TYR66 |
| A | PRO69 |
| A | HIS105 |
| A | HOH904 |
| A | HOH982 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 404 |
| Chain | Residue |
| A | GLY109 |
| A | TYR110 |
| A | ASN111 |
| A | ASN112 |
| A | GLN158 |
| A | DMS406 |
| A | HOH854 |
| A | HOH870 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 405 |
| Chain | Residue |
| A | PHE114 |
| A | TRP115 |
| A | HIS146 |
| A | TYR157 |
| A | UBY401 |
| A | HOH674 |
| A | HOH702 |
| A | HOH715 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS A 406 |
| Chain | Residue |
| A | TYR110 |
| A | ASN112 |
| A | PHE114 |
| A | UBY401 |
| A | UBY401 |
| A | GOL404 |
| A | HOH761 |
| A | HOH990 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 407 |
| Chain | Residue |
| A | ILE1 |
| A | THR2 |
| A | GLY3 |
| A | GLN31 |
| A | ASN33 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS A 408 |
| Chain | Residue |
| A | TYR66 |
| A | HIS216 |
| A | SER218 |
| A | TYR251 |
| A | HOH628 |
| A | HOH833 |
| A | HOH940 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS A 409 |
| Chain | Residue |
| A | THR2 |
| A | THR4 |
| A | TYR24 |
| A | SER25 |
| A | TYR28 |
| A | HOH531 |
| A | HOH877 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 410 |
| Chain | Residue |
| A | HIS142 |
| A | HIS146 |
| A | GLU166 |
| A | UBY401 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 411 |
| Chain | Residue |
| A | GLU177 |
| A | ASN183 |
| A | ASP185 |
| A | GLU190 |
| A | HOH692 |
| A | HOH748 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 412 |
| Chain | Residue |
| A | ASP138 |
| A | GLU177 |
| A | ASP185 |
| A | GLU187 |
| A | GLU190 |
| A | HOH984 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 413 |
| Chain | Residue |
| A | ASP200 |
| A | HOH946 |
| A | HOH985 |
| A | TYR193 |
| A | THR194 |
| A | ILE197 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 414 |
| Chain | Residue |
| A | ASP57 |
| A | ASP59 |
| A | GLN61 |
| A | HOH944 |
| A | HOH945 |
| A | HOH947 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV |
| Chain | Residue | Details |
| A | VAL139-VAL148 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"4808703","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"4808703","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 176 |
| Chain | Residue | Details |
| A | HIS142 | metal ligand |
| A | GLU143 | electrostatic stabiliser, metal ligand |
| A | HIS146 | metal ligand |
| A | TYR157 | electrostatic stabiliser, hydrogen bond donor, steric role |
| A | GLU166 | metal ligand |
| A | ASP226 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| A | HIS231 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
