3T60
5'-Diphenyl Nucleoside Inhibitors of Plasmodium falciparum dUTPase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004170 | molecular_function | dUTP diphosphatase activity |
| A | 0006226 | biological_process | dUMP biosynthetic process |
| A | 0006260 | biological_process | DNA replication |
| A | 0006399 | biological_process | tRNA metabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046081 | biological_process | dUTP catabolic process |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004170 | molecular_function | dUTP diphosphatase activity |
| B | 0006226 | biological_process | dUMP biosynthetic process |
| B | 0006260 | biological_process | DNA replication |
| B | 0006399 | biological_process | tRNA metabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046081 | biological_process | dUTP catabolic process |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004170 | molecular_function | dUTP diphosphatase activity |
| C | 0006226 | biological_process | dUMP biosynthetic process |
| C | 0006260 | biological_process | DNA replication |
| C | 0006399 | biological_process | tRNA metabolic process |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046081 | biological_process | dUTP catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE DUA A 182 |
| Chain | Residue |
| A | PHE46 |
| B | SER93 |
| B | SER95 |
| A | LEU88 |
| A | ASN103 |
| A | GLY106 |
| A | TYR112 |
| A | ILE117 |
| A | ALA119 |
| A | HOH191 |
| B | SER92 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 183 |
| Chain | Residue |
| A | ARG91 |
| A | SER92 |
| A | SER93 |
| A | GLN138 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE DUA B 182 |
| Chain | Residue |
| B | PHE46 |
| B | LEU88 |
| B | ASN103 |
| B | GLY106 |
| B | LEU107 |
| B | TYR112 |
| B | ILE117 |
| B | HOH198 |
| B | HOH205 |
| C | SER92 |
| C | SER93 |
| C | SER95 |
| C | HOH199 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 183 |
| Chain | Residue |
| B | ARG91 |
| B | SER92 |
| B | SER93 |
| B | GLN138 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE DUA C 182 |
| Chain | Residue |
| A | SER92 |
| A | SER93 |
| A | SER95 |
| C | PHE46 |
| C | LEU88 |
| C | ASN103 |
| C | GLY106 |
| C | LEU107 |
| C | TYR112 |
| C | ILE117 |
| C | ALA119 |
| C | HOH207 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 183 |
| Chain | Residue |
| C | ARG91 |
| C | SER92 |
| C | SER93 |
| C | GLN138 |
