3T45

Crystal structure of bacteriorhodopsin mutant A215T, a phototaxis signaling mutant at 3.0 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE RET A 301

Chain	Residue
A	TRP86
A	PRO186
A	TRP189
A	LYS216
A	THR90
A	LEU93
A	MET118
A	TRP138
A	SER141
A	THR142
A	TRP182
A	TYR185

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE RET B 301

Chain	Residue
B	TRP86
B	THR90
B	LEU93
B	MET118
B	TRP138
B	SER141
B	THR142
B	TRP182
B	TYR185
B	PRO186
B	TRP189
B	ASP212
B	LYS216

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE RET C 301

Chain	Residue
C	TRP86
C	THR90
C	LEU93
C	MET118
C	TRP138
C	SER141
C	THR142
C	TRP182
C	TYR185
C	PRO186
C	TRP189
C	ASP212
C	LYS216

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LI1 A 600

Chain	Residue
A	PHE135
A	LEU190
A	ALA196
B	TRP12
B	ILE203

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LI1 B 602

Chain	Residue
A	TYR64
B	GLY113
B	GLY116
B	ILE117

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LI1 B 603

Chain	Residue
A	LEU15
B	LEU25
B	LEU58
C	ALA139
C	ILE140
C	LI1606

---

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LI1 B 604

Chain	Residue
A	LI1608
B	TYR64
B	TRP80
B	PHE88
B	LI1615
C	THR67
C	TRP80
C	ALA84
C	GLY116
C	GLY120
C	LEU123
C	LYS129

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LI1 B 605

Chain	Residue
B	LEU28
B	LYS40
B	ALA44
C	TYR147

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LI1 C 606

Chain	Residue
A	TRP12
A	GLY73
A	GLN75
A	ASN202
A	ILE203
B	LI1603
C	LEU190

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LI1 B 615

Chain	Residue
B	TRP80
B	LI1604

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LI1 B 611

Chain	Residue
B	TYR131
B	LEU190
B	LI1612
C	TRP12
C	ASN202
C	ILE203

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LI1 B 612

Chain	Residue
B	LI1611
C	VAL199
C	PRO200

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LI1 C 613

Chain	Residue
A	ILE117
A	TYR147
C	LEU25
C	LEU28
C	GLY31
C	PHE54

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LI1 A 608

Chain	Residue
A	GLY116
A	LEU127
B	LI1604
C	MET56
C	TYR64

---

Functional Information from PROSITE/UniProt

site_id	PS00327
Number of Residues	12
Details	BACTERIAL_OPSIN_RET Bacterial rhodopsins retinal binding site. FMVLDVsTKvGF

Chain	Residue	Details
A	PHE208-PHE219

---

site_id	PS00950
Number of Residues	13
Details	BACTERIAL_OPSIN_1 Bacterial rhodopsins signature 1. RYaDWlFTTPLLL

Chain	Residue	Details
A	ARG82-LEU94

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=Helix A","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	120
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=Helix B","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	99
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=Helix C","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=Helix D","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=Helix E","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=Helix F","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=Helix G","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	Site: {"description":"Primary proton acceptor","evidences":[{"source":"PubMed","id":"10903866","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"10949309","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	3
Details	Modified residue: {"description":"N6-(retinylidene)lysine","evidences":[{"source":"PubMed","id":"10452895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10467143","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10548112","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10903866","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10949307","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10949309","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11829498","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28008064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6794028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9287223","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9632391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9751724","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1F50","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KG8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KG9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O0A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q5J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QHJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QM8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R84","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TN5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UCQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1X0I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1X0K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1X0S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XJI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BRD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I1X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I20","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I21","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WJK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WJL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZFE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZZL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3COD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HAP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HAQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HAR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NSB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3T45","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VI0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FPD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MD1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MD2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X31","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X32","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5A44","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5A45","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5B34","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5B6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5B6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5B6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5B6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5B6Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BR5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J7A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---