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3T44

Crystal structure of Mycobacterium tuberculosis Indole Glycerol Phosphate Synthase (IGPS) in complex with indole glycerol phosphate (IGP) amd anthranilate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000162biological_processtryptophan biosynthetic process
A0000287molecular_functionmagnesium ion binding
A0004425molecular_functionindole-3-glycerol-phosphate synthase activity
A0004640molecular_functionphosphoribosylanthranilate isomerase activity
A0005886cellular_componentplasma membrane
A0006568biological_processtryptophan metabolic process
A0009274cellular_componentpeptidoglycan-based cell wall
A0016830molecular_functioncarbon-carbon lyase activity
A0016831molecular_functioncarboxy-lyase activity
A0046391biological_process5-phosphoribose 1-diphosphate metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE IGP A 300
ChainResidue
AGLU57
AGLY221
ALEU240
AVAL241
AGLY242
AGLU243
ABE2273
AHOH346
AHOH358
AHOH378
AHOH551
ALYS59
ALYS119
APHE121
ALEU140
AGLU168
AASN189
AGLU219
ASER220

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE BE2 A 273
ChainResidue
ASER62
APRO63
ASER64
APHE98
AARG191
ALEU193
ALEU196
AIGP300
AHOH396
AHOH450

Functional Information from PROSITE/UniProt
site_idPS00614
Number of Residues18
DetailsIGPS Indole-3-glycerol phosphate synthase signature. VIaEVKRASPSagalat.I
ChainResidueDetails
AVAL54-ILE71

224004

PDB entries from 2024-08-21

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