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3T40

Crystal Structure of Mycobacterium tuberculosis Indole Glycerol Phosphate Synthase (IGPS) complex with N-2-Carboxyphenyl Glycine (CPG)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000162biological_processtryptophan biosynthetic process
A0000287molecular_functionmagnesium ion binding
A0004425molecular_functionindole-3-glycerol-phosphate synthase activity
A0004640molecular_functionphosphoribosylanthranilate isomerase activity
A0005886cellular_componentplasma membrane
A0006568biological_processtryptophan metabolic process
A0009274cellular_componentpeptidoglycan-based cell wall
A0016830molecular_functioncarbon-carbon lyase activity
A0016831molecular_functioncarboxy-lyase activity
A0046391biological_process5-phosphoribose 1-diphosphate metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 3RG A 273
ChainResidue
AGLU57
AHOH669
ALYS59
APHE98
ALYS119
AASP120
ALEU140
AILE142
AGLU168
AASN189

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 274
ChainResidue
AGLU57
ALYS59
ALEU240
AVAL241
AGLY242
AHOH289

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 275
ChainResidue
AGLU12
AGLY51
AILE52
ALEU258
AVAL259
AALA261
AHOH336

Functional Information from PROSITE/UniProt
site_idPS00614
Number of Residues18
DetailsIGPS Indole-3-glycerol phosphate synthase signature. VIaEVKRASPSagalat.I
ChainResidueDetails
AVAL54-ILE71

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PDB entries from 2024-07-17

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