3SXN

Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008080	molecular_function	N-acetyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0030649	biological_process	aminoglycoside antibiotic catabolic process
A	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
A	0044161	cellular_component	host cell cytoplasmic vesicle
B	0008080	molecular_function	N-acetyltransferase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0030649	biological_process	aminoglycoside antibiotic catabolic process
B	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
B	0044161	cellular_component	host cell cytoplasmic vesicle
C	0008080	molecular_function	N-acetyltransferase activity
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0030649	biological_process	aminoglycoside antibiotic catabolic process
C	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
C	0044161	cellular_component	host cell cytoplasmic vesicle
D	0008080	molecular_function	N-acetyltransferase activity
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0030649	biological_process	aminoglycoside antibiotic catabolic process
D	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
D	0044161	cellular_component	host cell cytoplasmic vesicle
E	0008080	molecular_function	N-acetyltransferase activity
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0030649	biological_process	aminoglycoside antibiotic catabolic process
E	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
E	0044161	cellular_component	host cell cytoplasmic vesicle
F	0008080	molecular_function	N-acetyltransferase activity
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
F	0030649	biological_process	aminoglycoside antibiotic catabolic process
F	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
F	0044161	cellular_component	host cell cytoplasmic vesicle

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE COA A 500

Chain	Residue
A	PHE26
A	LEU97
A	ARG98
A	THR119
A	SER121
A	GLU122
A	GLY124
A	ILE125
A	TYR126
A	ARG128
A	HOH676
A	VAL85
A	HOH685
A	HOH689
A	HOH773
A	HOH894
A	HOH900
F	ASP258
A	ALA86
A	VAL87
A	ARG92
A	ARG93
A	ARG94
A	GLY95
A	VAL96

---

site_id	AC2
Number of Residues	25
Details	BINDING SITE FOR RESIDUE COA B 500

Chain	Residue
B	PHE26
B	VAL85
B	ALA86
B	VAL87
B	ARG92
B	ARG93
B	ARG94
B	GLY95
B	VAL96
B	LEU97
B	ARG98
B	THR119
B	SER121
B	GLU122
B	GLY124
B	ILE125
B	TYR126
B	ARG128
B	HOH614
B	HOH766
B	HOH830
B	HOH856
B	HOH919
B	HOH978
D	ASP258

---

site_id	AC3
Number of Residues	25
Details	BINDING SITE FOR RESIDUE COA C 500

Chain	Residue
A	ASP258
C	PHE26
C	VAL85
C	ALA86
C	VAL87
C	ARG92
C	ARG93
C	ARG94
C	GLY95
C	VAL96
C	LEU97
C	ARG98
C	THR119
C	SER121
C	GLU122
C	GLY124
C	ILE125
C	TYR126
C	ARG128
C	HOH645
C	HOH689
C	HOH816
C	HOH839
C	HOH855
C	HOH861

---

site_id	AC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE COA D 500

Chain	Residue
D	ALA25
D	PHE26
D	VAL85
D	ALA86
D	VAL87
D	ARG92
D	ARG93
D	ARG94
D	GLY95
D	VAL96
D	LEU97
D	ARG98
D	THR119
D	SER121
D	GLU122
D	GLY124
D	ILE125
D	TYR126
D	ARG128
D	HOH809
D	HOH850
D	HOH918
E	ASP258

---

site_id	AC5
Number of Residues	21
Details	BINDING SITE FOR RESIDUE COA E 500

Chain	Residue
E	PHE26
E	VAL85
E	VAL87
E	ARG92
E	ARG93
E	ARG94
E	GLY95
E	VAL96
E	LEU97
E	ARG98
E	THR119
E	SER121
E	GLU122
E	GLY124
E	ILE125
E	TYR126
E	ARG128
E	HOH782
E	HOH800
E	HOH815
B	ASP258

---

site_id	AC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE COA F 500

Chain	Residue
C	ASP258
F	PHE26
F	VAL85
F	ALA86
F	VAL87
F	ARG92
F	ARG93
F	ARG94
F	GLY95
F	VAL96
F	LEU97
F	ARG98
F	SER121
F	GLU122
F	GLY124
F	ILE125
F	TYR126
F	ARG128
F	HOH654
F	HOH772

---