Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0003682 | molecular_function | chromatin binding |
A | 0003886 | molecular_function | DNA (cytosine-5-)-methyltransferase activity |
A | 0005634 | cellular_component | nucleus |
A | 0006346 | biological_process | DNA methylation-dependent heterochromatin formation |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE SFG A 300 |
Chain | Residue |
A | HOH58 |
A | GLU1168 |
A | MET1169 |
A | TRP1170 |
A | ASP1190 |
A | CYS1191 |
A | PRO1225 |
A | LEU1247 |
A | GLU1266 |
A | ASN1578 |
A | ALA1579 |
A | EDO119 |
A | VAL1580 |
A | HOH258 |
A | PHE1145 |
A | SER1146 |
A | GLY1147 |
A | GLY1149 |
A | GLY1150 |
A | LEU1151 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 1 |
Chain | Residue |
A | LEU623 |
A | GLU846 |
A | ARG1259 |
A | ARG1289 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MES A 2 |
Chain | Residue |
A | HOH46 |
A | PRO1182 |
A | GLY1183 |
A | THR1185 |
A | GLN1209 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MES A 4 |
Chain | Residue |
A | ARG778 |
A | HIS795 |
A | LEU816 |
A | TYR836 |
A | TYR865 |
A | VAL894 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 101 |
Chain | Residue |
A | EDO117 |
A | GLY1305 |
A | TRP1395 |
A | PHE1396 |
site_id | AC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO A 102 |
Chain | Residue |
A | HOH6 |
A | PHE1296 |
A | GLY1297 |
A | VAL1298 |
A | LEU1341 |
A | PHE1350 |
A | VAL1351 |
A | SER1352 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 103 |
Chain | Residue |
A | GLY1058 |
A | ARG1059 |
A | ASN1081 |
A | ARG1356 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 104 |
Chain | Residue |
A | EDO107 |
A | LEU1326 |
A | GLU1591 |
A | LEU1594 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 105 |
Chain | Residue |
A | EDO107 |
A | HOH255 |
A | LYS1593 |
site_id | BC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A 106 |
Chain | Residue |
A | TYR1035 |
A | HIS1036 |
A | ARG1368 |
A | ASP1369 |
A | SER1372 |
A | GLN1393 |
A | SER1394 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 107 |
Chain | Residue |
A | HOH25 |
A | EDO104 |
A | EDO105 |
A | PRO1080 |
site_id | BC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 108 |
Chain | Residue |
A | ASP870 |
A | ARG875 |
A | LEU1326 |
site_id | BC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 109 |
Chain | Residue |
A | TRP868 |
A | GLU877 |
A | SER878 |
A | PRO880 |
A | ARG898 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 110 |
Chain | Residue |
A | ASP706 |
A | ARG1269 |
A | SER1273 |
A | VAL1343 |
A | VAL1344 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 111 |
Chain | Residue |
A | VAL964 |
A | TYR969 |
A | HIS972 |
A | PRO1429 |
A | ASP1438 |
site_id | BC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A 112 |
Chain | Residue |
A | HOH262 |
A | PRO988 |
A | VAL1333 |
A | PHE1334 |
A | CYS1339 |
A | LEU1357 |
A | SER1358 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 113 |
Chain | Residue |
A | ARG1276 |
A | SER1277 |
A | VAL1345 |
A | ASP1346 |
site_id | BC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A 114 |
Chain | Residue |
A | LEU774 |
A | TYR775 |
A | LEU776 |
A | PHE797 |
A | ALA799 |
A | ASP802 |
A | HIS719 |
site_id | CC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 115 |
Chain | Residue |
A | LYS716 |
A | GLN720 |
A | GLU1202 |
A | THR1204 |
site_id | CC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO A 116 |
Chain | Residue |
A | TRP1165 |
A | ARG1210 |
site_id | CC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A 117 |
Chain | Residue |
A | HOH24 |
A | EDO101 |
A | EDO118 |
A | HOH278 |
A | ILE1039 |
A | HIS1332 |
A | TRP1395 |
site_id | CC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 118 |
Chain | Residue |
A | EDO117 |
A | HOH277 |
A | ASN1040 |
A | SER1076 |
A | ARG1082 |
A | TRP1395 |
site_id | CC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 119 |
Chain | Residue |
A | SFG300 |
A | GLY1223 |
A | GLU1266 |
A | ASN1267 |
A | ARG1312 |
A | ASN1578 |
site_id | CC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 120 |
Chain | Residue |
A | VAL705 |
A | ARG1311 |
A | ARG1337 |
A | ALA1338 |
site_id | CC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO A 121 |
Chain | Residue |
A | CYS653 |
A | ASN1529 |
site_id | CC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 122 |
Chain | Residue |
A | GLY654 |
A | TRP1510 |
A | MET1533 |
site_id | CC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 123 |
Chain | Residue |
A | PRO1429 |
A | LEU1430 |
A | ALA1431 |
site_id | DC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 124 |
Chain | Residue |
A | EDO125 |
A | THR1366 |
A | ASP1520 |
site_id | DC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 125 |
Chain | Residue |
A | HOH53 |
A | HOH83 |
A | EDO124 |
A | THR1031 |
site_id | DC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 1601 |
Chain | Residue |
A | CYS653 |
A | CYS656 |
A | CYS659 |
A | CYS691 |
site_id | DC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN A 1602 |
Chain | Residue |
A | CYS664 |
A | GLY665 |
A | CYS667 |
A | CYS670 |
A | CYS686 |
site_id | DC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 3 |
Chain | Residue |
A | HIS793 |
A | CYS820 |
A | CYS893 |
A | CYS896 |
site_id | DC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 1603 |
Chain | Residue |
A | CYS1476 |
A | CYS1478 |
A | CYS1485 |
A | HIS1502 |
Functional Information from PROSITE/UniProt
site_id | PS00094 |
Number of Residues | 13 |
Details | C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. EmLcgGpPCqGFS |
Chain | Residue | Details |
A | GLU1218-SER1230 | |
site_id | PS00095 |
Number of Residues | 19 |
Details | C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. RqvGNAVpPpLakaIgleI |
Chain | Residue | Details |
A | ARG1574-ILE1592 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ASN646-PRO692 | |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: |
Chain | Residue | Details |
A | CYS1226 | |
Chain | Residue | Details |
A | CYS653 | |
A | CYS656 | |
A | CYS659 | |
A | CYS664 | |
A | CYS667 | |
A | CYS670 | |
A | CYS686 | |
A | CYS691 | |
Chain | Residue | Details |
A | SER1146 | |
A | GLY1150 | |
A | ASP1190 | |
A | VAL1580 | |
Chain | Residue | Details |
A | GLU1168 | |
A | CYS1191 | |
A | ASN1578 | |
Chain | Residue | Details |
A | SER714 | |
Chain | Residue | Details |
A | SER732 | |
Chain | Residue | Details |
A | LYS749 | |
A | LYS891 | |
A | LYS957 | |
A | LYS961 | |
A | LYS975 | |
A | LYS1054 | |
A | LYS1349 | |
A | LYS1415 | |
Chain | Residue | Details |
A | SER878 | |
Chain | Residue | Details |
A | LYS1111 | |
A | LYS1113 | |
A | LYS1115 | |
Chain | Residue | Details |
A | LYS1117 | |
Chain | Residue | Details |
A | LYS1119 | |
A | LYS1121 | |