3SQZ
Crystal structure of HMG_CoA synthase complexed with CoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004421 | molecular_function | hydroxymethylglutaryl-CoA synthase activity |
| A | 0006084 | biological_process | acetyl-CoA metabolic process |
| A | 0006696 | biological_process | ergosterol biosynthetic process |
| A | 0010142 | biological_process | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| A | 0016746 | molecular_function | acyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 392 |
| Chain | Residue |
| A | PHE10 |
| A | HOH729 |
| A | THR11 |
| A | SER12 |
| A | ARG332 |
| A | HOH397 |
| A | HOH518 |
| A | HOH592 |
| A | HOH662 |
| A | HOH680 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 393 |
| Chain | Residue |
| A | LYS250 |
| A | VAL252 |
| A | PRO253 |
| A | SER254 |
| A | GLN257 |
| A | LEU379 |
| A | HOH744 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE COA A 601 |
| Chain | Residue |
| A | ASP29 |
| A | GLN31 |
| A | LYS32 |
| A | GLY36 |
| A | TYR143 |
| A | PRO148 |
| A | GLY149 |
| A | SER151 |
| A | THR152 |
| A | PHE185 |
| A | GLY198 |
| A | SER201 |
| A | LYS218 |
| A | HIS233 |
| A | PHE236 |
| A | LYS238 |
| A | LEU239 |
| A | LYS242 |
| A | SER309 |
| A | HOH573 |
| A | HOH584 |
| A | HOH598 |
| A | HOH600 |
| A | HOH627 |
| A | HOH637 |
