3SQZ

Crystal structure of HMG_CoA synthase complexed with CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004421	molecular_function	hydroxymethylglutaryl-CoA synthase activity
A	0006084	biological_process	acetyl-CoA metabolic process
A	0010142	biological_process	farnesyl diphosphate biosynthetic process, mevalonate pathway
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 392

Chain	Residue
A	PHE10
A	HOH729
A	THR11
A	SER12
A	ARG332
A	HOH397
A	HOH518
A	HOH592
A	HOH662
A	HOH680

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 393

Chain	Residue
A	LYS250
A	VAL252
A	PRO253
A	SER254
A	GLN257
A	LEU379
A	HOH744

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site_id	AC3
Number of Residues	25
Details	BINDING SITE FOR RESIDUE COA A 601

Chain	Residue
A	ASP29
A	GLN31
A	LYS32
A	GLY36
A	TYR143
A	PRO148
A	GLY149
A	SER151
A	THR152
A	PHE185
A	GLY198
A	SER201
A	LYS218
A	HIS233
A	PHE236
A	LYS238
A	LEU239
A	LYS242
A	SER309
A	HOH573
A	HOH584
A	HOH598
A	HOH600
A	HOH627
A	HOH637

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