3SQD

Crystal structure of human PTIP BRCT5/6-gamma H2AX complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0044666	cellular_component	MLL3/4 complex
B	0044666	cellular_component	MLL3/4 complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	162
Details	Domain: {"description":"BRCT 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00033","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	178
Details	Domain: {"description":"BRCT 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00033","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Motif: {"description":"[ST]-Q motif"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by ATM, ATR and PRKDC","evidences":[{"source":"PubMed","id":"10477747","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10734083","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10959836","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11673449","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12419185","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12607005","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12660252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12697768","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14627815","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15059890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15489221","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15613478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17709392","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22154951","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9488723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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