3SPG
Inward rectifier potassium channel Kir2.2 R186A mutant in complex with PIP2
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE K A 501 |
| Chain | Residue |
| A | GLY145 |
| A | K502 |
| A | K502 |
| A | K502 |
| A | GLY145 |
| A | GLY145 |
| A | GLY145 |
| A | TYR146 |
| A | TYR146 |
| A | TYR146 |
| A | TYR146 |
| A | K502 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE K A 502 |
| Chain | Residue |
| A | ILE144 |
| A | ILE144 |
| A | ILE144 |
| A | ILE144 |
| A | GLY145 |
| A | GLY145 |
| A | GLY145 |
| A | GLY145 |
| A | K501 |
| A | K501 |
| A | K501 |
| A | K501 |
| A | K503 |
| A | K503 |
| A | K503 |
| A | K503 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE K A 503 |
| Chain | Residue |
| A | THR143 |
| A | THR143 |
| A | THR143 |
| A | THR143 |
| A | ILE144 |
| A | ILE144 |
| A | ILE144 |
| A | ILE144 |
| A | K502 |
| A | K502 |
| A | K502 |
| A | K502 |
| A | K504 |
| A | K504 |
| A | K504 |
| A | K504 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE K A 504 |
| Chain | Residue |
| A | THR143 |
| A | THR143 |
| A | THR143 |
| A | THR143 |
| A | K503 |
| A | K503 |
| A | K503 |
| A | K503 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PIO A 400 |
| Chain | Residue |
| A | ARG78 |
| A | TRP79 |
| A | ARG80 |
| A | LEU83 |
| A | LYS183 |
| A | LYS188 |
| A | LYS189 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=M1","evidences":[{"source":"PubMed","id":"21874019","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SPC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"21874019","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Intramembrane: {"description":"Helical; Pore-forming; Name=H5","evidences":[{"source":"PubMed","id":"21874019","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SPC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=M2","evidences":[{"source":"PubMed","id":"21874019","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SPC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"20019282","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21874019","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21874019","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SPI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
