3SN6
Crystal structure of the beta2 adrenergic receptor-Gs protein complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005159 | molecular_function | insulin-like growth factor receptor binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005834 | cellular_component | heterotrimeric G-protein complex |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| A | 0007606 | biological_process | sensory perception of chemical stimulus |
| A | 0010856 | molecular_function | adenylate cyclase activator activity |
| A | 0019001 | molecular_function | guanyl nucleotide binding |
| A | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
| A | 0031698 | molecular_function | beta-2 adrenergic receptor binding |
| A | 0031748 | molecular_function | D1 dopamine receptor binding |
| A | 0031852 | molecular_function | mu-type opioid receptor binding |
| A | 0035255 | molecular_function | ionotropic glutamate receptor binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051430 | molecular_function | corticotropin-releasing hormone receptor 1 binding |
| A | 0071880 | biological_process | adenylate cyclase-activating adrenergic receptor signaling pathway |
| B | 0001750 | cellular_component | photoreceptor outer segment |
| B | 0001917 | cellular_component | photoreceptor inner segment |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005834 | cellular_component | heterotrimeric G-protein complex |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| B | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| B | 0008283 | biological_process | cell population proliferation |
| B | 0010659 | biological_process | cardiac muscle cell apoptotic process |
| B | 0030159 | molecular_function | signaling receptor complex adaptor activity |
| B | 0030425 | cellular_component | dendrite |
| B | 0030507 | molecular_function | spectrin binding |
| B | 0042622 | cellular_component | photoreceptor outer segment membrane |
| B | 0044297 | cellular_component | cell body |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0045202 | cellular_component | synapse |
| B | 0047391 | molecular_function | alkylglycerophosphoethanolamine phosphodiesterase activity |
| B | 0050909 | biological_process | sensory perception of taste |
| B | 0051020 | molecular_function | GTPase binding |
| B | 0060041 | biological_process | retina development in camera-type eye |
| B | 0071456 | biological_process | cellular response to hypoxia |
| G | 0003924 | molecular_function | GTPase activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005834 | cellular_component | heterotrimeric G-protein complex |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0007165 | biological_process | signal transduction |
| G | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| G | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| G | 0016020 | cellular_component | membrane |
| G | 0031681 | molecular_function | G-protein beta-subunit binding |
| G | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| G | 0071870 | biological_process | cellular response to catecholamine stimulus |
| R | 0003796 | molecular_function | lysozyme activity |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0004941 | molecular_function | beta2-adrenergic receptor activity |
| R | 0006940 | biological_process | regulation of smooth muscle contraction |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| R | 0009253 | biological_process | peptidoglycan catabolic process |
| R | 0016020 | cellular_component | membrane |
| R | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| R | 0016998 | biological_process | cell wall macromolecule catabolic process |
| R | 0030430 | cellular_component | host cell cytoplasm |
| R | 0031640 | biological_process | killing of cells of another organism |
| R | 0042742 | biological_process | defense response to bacterium |
| R | 0044659 | biological_process | viral release from host cell by cytolysis |
| R | 0097746 | biological_process | blood vessel diameter maintenance |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE P0G R 366 |
| Chain | Residue |
| R | TRP109 |
| R | ASN293 |
| R | TYR308 |
| R | ASN312 |
| R | THR110 |
| R | ASP113 |
| R | VAL117 |
| R | PHE193 |
| R | SER203 |
| R | SER204 |
| R | SER207 |
| R | PHE290 |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIeTLCVIAVDRYFaI |
| Chain | Residue | Details |
| R | ALA119-ILE135 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| B | LEU70-SER84 | |
| B | ILE157-ILE171 | |
| B | LEU285-ALA299 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 |
| Chain | Residue | Details |
| R | GLU1011 | |
| A | LYS211 | |
| A | CYS237 | |
| A | SER306 | |
| A | ARG380 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 |
| Chain | Residue | Details |
| R | ASP1020 | |
| A | ASN218 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:8266098 |
| Chain | Residue | Details |
| R | LEU1032 | |
| R | PHE1104 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000303|PubMed:7831309 |
| Chain | Residue | Details |
| R | SER1117 | |
| R | ASN1132 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=1 |
| Chain | Residue | Details |
| R | GLY35-ILE58 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 85 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| R | ALA59-PHE71 | |
| R | ASP130-ALA150 | |
| R | ARG221-THR274 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=2 |
| Chain | Residue | Details |
| R | ILE72-LEU95 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 37 |
| Details | TOPO_DOM: Extracellular |
| Chain | Residue | Details |
| R | THR96-CYS106 | |
| R | ARG175-ASN196 | |
| R | GLN299-LYS305 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=3 |
| Chain | Residue | Details |
| R | GLU107-VAL129 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=4 |
| Chain | Residue | Details |
| R | ARG151-TYR174 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=5 |
| Chain | Residue | Details |
| R | GLN197-SER220 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=6 |
| Chain | Residue | Details |
| R | LEU275-ILE298 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=7 |
| Chain | Residue | Details |
| R | GLU306-SER329 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S |
| Chain | Residue | Details |
| R | ASP113 | |
| R | THR118 | |
| R | ASN293 | |
| R | ASN312 | |
| R | TYR316 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17952055, ECO:0000269|PubMed:17962520, ECO:0007744|PDB:2RH1 |
| Chain | Residue | Details |
| R | SER203 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:8521811 |
| Chain | Residue | Details |
| R | TYR141 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332 |
| Chain | Residue | Details |
| R | SER246 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000255 |
| Chain | Residue | Details |
| R | SER261 | |
| R | SER262 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:11146000 |
| Chain | Residue | Details |
| R | SER345 | |
| R | SER346 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by BARK => ECO:0000305 |
| Chain | Residue | Details |
| R | SER355 | |
| R | SER356 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:27481942 |
| Chain | Residue | Details |
| R | CYS265 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:17962520, ECO:0000269|PubMed:18547522, ECO:0000269|PubMed:2540197, ECO:0000269|PubMed:27481942 |
| Chain | Residue | Details |
| R | CYS341 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 921 |
| Chain | Residue | Details |
| R | GLU1011 | proton shuttle (general acid/base) |
| R | ASP1020 | covalent catalysis |
