3SMT

Crystal structure of human SET domain-containing protein3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0018064	molecular_function	protein-L-histidine N-tele-methyltransferase activity
A	0030047	biological_process	actin modification

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE SAM A 1000

Chain	Residue
A	ARG74
A	ASN277
A	HIS278
A	TYR312
A	SER324
A	PHE326
A	PHE328
A	HOH515
A	HOH545
A	HOH569
A	HOH603
A	GLU102
A	HOH762
A	HOH794
A	GLU103
A	PHE105
A	THR252
A	ARG253
A	ASP274
A	MSE275
A	CYS276

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ARS A 498

Chain	Residue
A	CYS296

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ARS A 499

Chain	Residue
A	CYS294

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PG4 A 4001

Chain	Residue
A	PHE100
A	ARG108
A	GLY305
A	GLU306
A	GLN307
A	ASP455
A	HOH525
A	HOH718

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 500

Chain	Residue
A	PHE367
A	ALA368
A	SER377
A	GLN379
A	HOH753
A	HOH789

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 1001

Chain	Residue
A	LEU340
A	GLY341
A	PHE387
A	PHE428
A	ARG432
A	HOH655

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30785395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31388018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31911441","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31993215","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32503840","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2011","submissionDatabase":"PDB data bank","title":"Crystal structure of human SET domain-containing protein 3.","authors":["Zeng H.","Dong A.","Walker J.R.","Loppnau P.","Bountra C.","Weigelt J.","Arrowsmith C.H.","Edwards A.M.","Min J.","Wu H."]}},{"source":"PDB","id":"3SMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ICT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ICV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JAT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WK1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WK2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---