3SIL
SIALIDASE FROM SALMONELLA TYPHIMURIUM
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004308 | molecular_function | exo-alpha-sialidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006689 | biological_process | ganglioside catabolic process |
| A | 0009313 | biological_process | oligosaccharide catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0052794 | molecular_function | exo-alpha-(2->3)-sialidase activity |
| A | 0052795 | molecular_function | exo-alpha-(2->6)-sialidase activity |
| A | 0052796 | molecular_function | exo-alpha-(2->8)-sialidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K A 450 |
| Chain | Residue |
| A | ASP62 |
| A | GOL402 |
| A | PO4499 |
| A | HOH790 |
| A | HOH958 |
| A | HOH1052 |
| A | HOH1054 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PO4 A 499 |
| Chain | Residue |
| A | TYR307 |
| A | ARG309 |
| A | TYR342 |
| A | K450 |
| A | HOH532 |
| A | HOH958 |
| A | HOH982 |
| A | HOH1051 |
| A | HOH1052 |
| A | HOH1053 |
| A | HOH1054 |
| A | HOH1055 |
| A | HOH1056 |
| A | ARG37 |
| A | ARG246 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 401 |
| Chain | Residue |
| A | GLU14 |
| A | HIS15 |
| A | LYS82 |
| A | HOH616 |
| A | HOH869 |
| A | HOH914 |
| A | HOH960 |
| A | HOH1002 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 402 |
| Chain | Residue |
| A | VAL178 |
| A | GLN194 |
| A | GLU231 |
| A | GOL403 |
| A | K450 |
| A | HOH664 |
| A | HOH790 |
| A | HOH982 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL A 403 |
| Chain | Residue |
| A | ASP62 |
| A | GLN63 |
| A | ARG97 |
| A | MET99 |
| A | ASP100 |
| A | TRP121 |
| A | LYS126 |
| A | THR127 |
| A | TRP128 |
| A | GOL402 |
| A | HOH825 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 404 |
| Chain | Residue |
| A | VAL105 |
| A | ALA106 |
| A | ASN107 |
| A | GLU112 |
| A | ALA239 |
| A | ARG348 |
| A | HOH964 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL A 405 |
| Chain | Residue |
| A | LYS120 |
| A | ASN122 |
| A | TRP140 |
| A | ASP141 |
| A | HIS374 |
| A | VAL377 |
| A | HOH584 |
| A | HOH769 |
| A | HOH1059 |
| A | HOH1060 |
| A | HOH1061 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 406 |
| Chain | Residue |
| A | CYS42 |
| A | ILE104 |
| A | VAL105 |
| A | GLY181 |
| A | LEU182 |
| A | GLN183 |
| A | HOH684 |
| A | HOH749 |
| A | HOH822 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250 |
| Chain | Residue | Details |
| A | GLN63 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000250 |
| Chain | Residue | Details |
| A | SER343 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | ALA362 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ILE38 | |
| A | ASN247 | |
| A | SER310 |
