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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3SHI

Crystal structure of human MMP1 catalytic domain at 2.2 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0031012	cellular_component	extracellular matrix
G	0004222	molecular_function	metalloendopeptidase activity
G	0006508	biological_process	proteolysis
G	0008237	molecular_function	metallopeptidase activity
G	0008270	molecular_function	zinc ion binding
G	0031012	cellular_component	extracellular matrix
M	0004222	molecular_function	metalloendopeptidase activity
M	0006508	biological_process	proteolysis
M	0008237	molecular_function	metallopeptidase activity
M	0008270	molecular_function	zinc ion binding
M	0031012	cellular_component	extracellular matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	HIS218
A	HIS222
A	HIS228
A	HOH287

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 302

Chain	Residue
A	HIS168
A	ASP170
A	HIS183
A	HIS196

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 303

Chain	Residue
A	GLY176
A	GLY178
A	ASN180
A	ASP198
A	GLU201
A	ASP175

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 304

Chain	Residue
A	ASP124
A	GLU199
A	GLU201
A	HOH338
M	HOH1
M	HOH287

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 305

Chain	Residue
A	HOH17
A	ASP158
A	GLY190
A	GLY192
A	ASP194
A	HOH309

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 301

Chain	Residue
G	HIS218
G	HIS222
G	HIS228
G	HOH290

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 302

Chain	Residue
G	HIS168
G	ASP170
G	HIS183
G	HIS196

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 303

Chain	Residue
G	ASP175
G	GLY176
G	GLY178
G	ASN180
G	ASP198
G	GLU201

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA G 304

Chain	Residue
A	HOH16
A	HOH94
G	ASP124
G	GLU199
G	GLU201

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA G 305

Chain	Residue
G	ASP158
G	GLY190
G	GLY192
G	ASP194
G	HOH285

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN M 301

Chain	Residue
M	HOH70
M	HIS218
M	HIS222
M	HIS228
M	HOH268

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN M 302

Chain	Residue
M	HIS168
M	ASP170
M	HIS183
M	HIS196

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA M 303

Chain	Residue
M	ASP175
M	GLY176
M	GLY178
M	ASN180
M	ASP198
M	GLU201

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA M 304

Chain	Residue
M	HOH31
M	ASP124
M	GLU199
M	GLU201

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA M 305

Chain	Residue
M	ASP158
M	GLY190
M	GLY192
M	ASP194

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHELGHSL

Chain	Residue	Details
A	VAL215-LEU224

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE:

Chain	Residue	Details
A	GLU219
G	GLU219
M	GLU219

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:8031754, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	ASP124
G	ASP124
M	ASP124

site_id	SWS_FT_FI3
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	ASP158
A	GLY190
A	ASP194
G	ASP158
G	GLY190
G	ASP194
M	ASP158
M	GLY190
M	ASP194

site_id	SWS_FT_FI4
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0000269\|PubMed:9484219, ECO:0007744\|PDB:1AYK, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2AYK, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3AYK, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:4AYK, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	HIS168
G	HIS218
G	HIS222
G	HIS228
M	HIS168
M	HIS183
M	HIS196
M	HIS218
M	HIS222
M	HIS228
A	HIS183
A	HIS196
A	HIS218
A	HIS222
A	HIS228
G	HIS168
G	HIS183
G	HIS196

site_id	SWS_FT_FI5
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0000269\|PubMed:9484219, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2AYK, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	ASP170
G	ASP170
M	ASP170

site_id	SWS_FT_FI6
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	ASP175
G	ASP175
M	ASP175

site_id	SWS_FT_FI7
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0000269\|PubMed:9484219, ECO:0007744\|PDB:1AYK, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2AYK, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:4AYK, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	GLY176
G	GLY176
M	GLY176

site_id	SWS_FT_FI8
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0000269\|PubMed:9484219, ECO:0007744\|PDB:1AYK, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2AYK, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	GLY178
A	ASN180
G	GLY178
G	ASN180
M	GLY178
M	ASN180

site_id	SWS_FT_FI9
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	GLY192
G	GLY192
M	GLY192

site_id	SWS_FT_FI10
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3AYK, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:4AYK, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	ASP198
G	ASP198
M	ASP198

site_id	SWS_FT_FI11
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:8031754, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	GLU199
G	GLU199
M	GLU199

site_id	SWS_FT_FI12
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0000269\|PubMed:9484219, ECO:0007744\|PDB:1AYK, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2AYK, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3AYK, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	GLU201
G	GLU201
M	GLU201

site_id	SWS_FT_FI13
Number of Residues	3
Details	SITE: Not glycosylated => ECO:0000269\|PubMed:10092871

Chain	Residue	Details
A	ASN143
G	ASN143
M	ASN143

site_id	SWS_FT_FI14
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:10092871

Chain	Residue	Details
A	ASN120
G	ASN120
M	ASN120

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