3SFU
crystal structure of murine norovirus RNA dependent RNA polymerase in complex with ribavirin
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003723 | molecular_function | RNA binding |
A | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
A | 0004386 | molecular_function | helicase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006351 | biological_process | DNA-templated transcription |
A | 0039694 | biological_process | viral RNA genome replication |
B | 0003723 | molecular_function | RNA binding |
B | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
B | 0004386 | molecular_function | helicase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006351 | biological_process | DNA-templated transcription |
B | 0039694 | biological_process | viral RNA genome replication |
C | 0003723 | molecular_function | RNA binding |
C | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
C | 0004386 | molecular_function | helicase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0006351 | biological_process | DNA-templated transcription |
C | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE RBV A 601 |
Chain | Residue |
A | ASP250 |
A | HOH866 |
A | THR308 |
A | THR309 |
A | ASN312 |
A | TYR344 |
A | GLY345 |
A | ASP346 |
A | ASP347 |
A | HOH844 |
site_id | AC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 A 602 |
Chain | Residue |
A | TRP134 |
A | HOH766 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 603 |
Chain | Residue |
A | THR148 |
A | HIS149 |
A | ASN152 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 A 604 |
Chain | Residue |
A | HIS241 |
A | THR387 |
A | LEU388 |
A | TRP405 |
A | HOH763 |
A | HOH857 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 605 |
Chain | Residue |
A | LYS29 |
A | HIS426 |
A | GLN427 |
A | GLU431 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 606 |
Chain | Residue |
A | TYR246 |
A | THR247 |
A | ARG248 |
A | HOH822 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 607 |
Chain | Residue |
A | ARG7 |
A | PRO8 |
A | SER9 |
A | SER61 |
A | ARG67 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 608 |
Chain | Residue |
A | LYS158 |
A | SER159 |
A | HOH843 |
site_id | AC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 A 609 |
Chain | Residue |
A | ARG408 |
A | GOL615 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 610 |
Chain | Residue |
A | ASP243 |
A | ASP347 |
A | GLU348 |
A | SER392 |
A | HOH802 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 611 |
Chain | Residue |
A | SER27 |
A | THR28 |
A | LYS29 |
A | ASN425 |
site_id | BC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 612 |
Chain | Residue |
A | GLY400 |
A | ASP401 |
A | TRP405 |
site_id | BC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 614 |
Chain | Residue |
A | SER223 |
A | MET224 |
A | ASN225 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 615 |
Chain | Residue |
A | ASP410 |
A | ARG411 |
A | HIS453 |
A | SO4609 |
site_id | BC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 616 |
Chain | Residue |
A | THR328 |
A | LEU354 |
A | GLU355 |
B | THR328 |
B | GLU355 |
B | GOL613 |
B | GOL618 |
site_id | BC7 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 617 |
Chain | Residue |
A | ARG96 |
A | PHE215 |
A | ASN216 |
A | PRO217 |
A | ARG219 |
A | MET336 |
A | GLU340 |
A | PHE341 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 618 |
Chain | Residue |
A | PRO103 |
A | GLN104 |
A | LEU268 |
A | PRO270 |
site_id | BC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 619 |
Chain | Residue |
A | SER115 |
A | ASP207 |
A | PRO306 |
site_id | CC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 620 |
Chain | Residue |
A | PRO6 |
A | ALA18 |
A | TYR293 |
site_id | CC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE RBV B 601 |
Chain | Residue |
B | ASP250 |
B | THR309 |
B | ASN312 |
B | GLY345 |
B | ASP346 |
B | ASP347 |
B | HOH747 |
B | HOH776 |
site_id | CC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 B 602 |
Chain | Residue |
B | HIS149 |
B | ASN152 |
site_id | CC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 B 603 |
Chain | Residue |
B | TYR246 |
B | ARG248 |
site_id | CC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 604 |
Chain | Residue |
B | HOH714 |
A | LYS158 |
B | LYS29 |
B | HIS426 |
B | GLN427 |
site_id | CC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 605 |
Chain | Residue |
B | LYS158 |
B | SER159 |
B | HOH765 |
site_id | CC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 606 |
Chain | Residue |
B | ASP410 |
B | ARG411 |
B | HIS453 |
site_id | CC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 607 |
Chain | Residue |
B | GLY51 |
B | SER52 |
B | SER61 |
B | LEU62 |
B | GLN63 |
site_id | CC9 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE SO4 B 608 |
Chain | Residue |
B | ARG408 |
site_id | DC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG B 609 |
Chain | Residue |
B | ASP243 |
B | ASP347 |
B | GLU348 |
B | SER392 |
site_id | DC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL B 610 |
Chain | Residue |
B | SER223 |
B | MET224 |
B | ASN225 |
site_id | DC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL B 611 |
Chain | Residue |
B | VAL325 |
B | ARG329 |
B | ASP331 |
site_id | DC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL B 612 |
Chain | Residue |
B | SER27 |
B | THR28 |
B | LYS29 |
B | ASN425 |
site_id | DC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 613 |
Chain | Residue |
A | GLU338 |
A | ASN353 |
A | GOL616 |
B | VAL327 |
B | ARG329 |
B | LYS360 |
B | HOH764 |
site_id | DC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL B 614 |
Chain | Residue |
B | PRO82 |
B | GLN83 |
B | HOH750 |
site_id | DC7 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE GOL B 615 |
Chain | Residue |
B | ARG248 |
site_id | DC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL B 616 |
Chain | Residue |
B | ASP401 |
B | TRP405 |
C | ASN237 |
site_id | DC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL B 617 |
Chain | Residue |
B | GLN104 |
B | LEU268 |
B | SER269 |
B | PRO270 |
site_id | EC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 618 |
Chain | Residue |
A | VAL327 |
A | LYS360 |
A | GOL616 |
B | GLU338 |
B | ASN353 |
B | LEU354 |
B | GLU355 |
site_id | EC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE RBV C 601 |
Chain | Residue |
C | LYS169 |
C | LEU186 |
C | LEU187 |
C | ASP250 |
C | LEU301 |
C | SER303 |
C | THR308 |
C | THR309 |
C | ASN312 |
C | TYR344 |
C | GLY345 |
C | ASP346 |
site_id | EC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 C 602 |
Chain | Residue |
C | HIS149 |
C | ASN152 |
site_id | EC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 C 603 |
Chain | Residue |
C | THR247 |
C | ARG248 |
C | HOH723 |
site_id | EC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG C 604 |
Chain | Residue |
C | ASP243 |
C | ASP347 |
C | GLU348 |
C | SER392 |
C | HOH767 |
site_id | EC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 C 605 |
Chain | Residue |
C | ARG408 |
C | HOH770 |
site_id | EC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL C 606 |
Chain | Residue |
C | GLN389 |
C | GLY400 |
C | ASP401 |
C | GOL616 |
site_id | EC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 C 607 |
Chain | Residue |
B | ALA236 |
C | ALA236 |
C | ASN237 |
site_id | EC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 608 |
Chain | Residue |
C | LYS158 |
C | SER159 |
C | HOH766 |
C | HOH805 |
site_id | FC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 C 609 |
Chain | Residue |
C | GLY51 |
C | SER52 |
C | SER61 |
C | LEU62 |
C | GLN63 |
site_id | FC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 C 610 |
Chain | Residue |
C | TRP134 |
C | GLY136 |
site_id | FC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE SO4 C 611 |
Chain | Residue |
C | ARG248 |
site_id | FC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 612 |
Chain | Residue |
C | VAL359 |
C | ARG366 |
C | GLY380 |
C | PRO381 |
site_id | FC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 C 613 |
Chain | Residue |
C | ARG374 |
C | ALA375 |
C | LEU382 |
C | GLU383 |
C | HOH774 |
C | HOH818 |
site_id | FC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 C 614 |
Chain | Residue |
C | TYR240 |
C | ARG384 |
C | GLN386 |
site_id | FC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 C 615 |
Chain | Residue |
C | ASP410 |
C | ARG411 |
C | HIS453 |
site_id | FC8 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL C 616 |
Chain | Residue |
B | ASN237 |
C | ALA236 |
C | PHE238 |
C | HIS241 |
C | THR387 |
C | LEU388 |
C | GLN389 |
C | TRP405 |
C | GOL606 |
site_id | FC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL C 617 |
Chain | Residue |
B | GLN64 |
B | ARG67 |
C | THR11 |
site_id | GC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL C 618 |
Chain | Residue |
C | SER223 |
C | MET224 |
C | ASN225 |
site_id | GC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL C 619 |
Chain | Residue |
C | SER27 |
C | THR28 |
C | LYS29 |
C | ASN425 |
site_id | GC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL C 620 |
Chain | Residue |
C | GLN146 |
C | HIS149 |
C | ALA150 |
C | ASP191 |
C | GLY193 |
C | HOH758 |
C | HOH855 |
site_id | GC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL C 621 |
Chain | Residue |
C | ARG96 |
C | PRO217 |
C | MET336 |
C | SER339 |
C | GLU340 |
C | PHE341 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21471315, ECO:0000269|PubMed:22341781, ECO:0000269|PubMed:24622391 |
Chain | Residue | Details |
A | ASP243 | |
A | GLU348 | |
B | ASP243 | |
B | GLU348 | |
C | ASP243 | |
C | GLU348 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21471315 |
Chain | Residue | Details |
A | ASP245 | |
B | ASP245 | |
C | ASP245 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21471315, ECO:0000269|PubMed:24622391 |
Chain | Residue | Details |
A | ASP347 | |
B | ASP347 | |
C | ASP347 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22341781, ECO:0000269|PubMed:24622391 |
Chain | Residue | Details |
A | SER392 | |
B | SER392 | |
C | SER392 |