3SFG
crystal structure of murine norovirus RNA dependent RNA polymerase in complex with 2thiouridine(2TU)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0039694 | biological_process | viral RNA genome replication |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| B | 0004386 | molecular_function | helicase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0039694 | biological_process | viral RNA genome replication |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| C | 0004386 | molecular_function | helicase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 2TU A 601 |
| Chain | Residue |
| A | ASP250 |
| A | LEU301 |
| A | SER303 |
| A | THR308 |
| A | THR309 |
| A | ASN312 |
| A | TYR344 |
| A | ASP346 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 602 |
| Chain | Residue |
| A | THR247 |
| A | ARG248 |
| A | TYR246 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 603 |
| Chain | Residue |
| A | THR148 |
| A | HIS149 |
| A | ASN152 |
| A | HOH745 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 604 |
| Chain | Residue |
| A | TRP134 |
| A | GLY136 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 605 |
| Chain | Residue |
| A | ARG374 |
| A | GLU383 |
| A | ARG385 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 606 |
| Chain | Residue |
| A | PRO103 |
| A | ARG486 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 607 |
| Chain | Residue |
| A | PRO82 |
| A | GLN83 |
| A | GLU84 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 608 |
| Chain | Residue |
| A | CYS90 |
| A | ASP91 |
| A | GLU94 |
| A | ARG260 |
| A | ILE264 |
| A | HOH718 |
| A | HOH817 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 609 |
| Chain | Residue |
| A | MET31 |
| A | LEU168 |
| A | LYS169 |
| A | ASP170 |
| A | LEU187 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 610 |
| Chain | Residue |
| A | ASP410 |
| A | ARG411 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 611 |
| Chain | Residue |
| A | SER27 |
| A | THR28 |
| A | LYS29 |
| A | ASN425 |
| A | HOH878 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 612 |
| Chain | Residue |
| A | ASP117 |
| A | THR120 |
| A | SER121 |
| A | LYS130 |
| A | MET195 |
| A | HOH734 |
| site_id | BC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 613 |
| Chain | Residue |
| A | LEU5 |
| A | SER9 |
| A | GLY10 |
| A | THR11 |
| A | THR11 |
| A | TYR12 |
| A | ALA13 |
| A | ARG67 |
| A | HOH876 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 614 |
| Chain | Residue |
| A | SER223 |
| A | MET224 |
| A | ASN225 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 615 |
| Chain | Residue |
| A | THR28 |
| A | GLY51 |
| A | SER52 |
| A | PRO60 |
| A | SER61 |
| A | LEU62 |
| A | HOH897 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 616 |
| Chain | Residue |
| A | LYS158 |
| A | SER159 |
| A | HOH850 |
| A | HOH910 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 617 |
| Chain | Residue |
| A | PHE109 |
| A | CYS113 |
| A | SER137 |
| A | ALA138 |
| A | PHE139 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 618 |
| Chain | Residue |
| A | ARG234 |
| A | ASN237 |
| A | GLU340 |
| A | ASP401 |
| A | GLN402 |
| A | GLY404 |
| A | HOH896 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 619 |
| Chain | Residue |
| A | PRO24 |
| A | SER121 |
| A | GLY123 |
| A | HIS127 |
| A | THR165 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 620 |
| Chain | Residue |
| A | LYS29 |
| A | ASN425 |
| A | HIS426 |
| A | GLN427 |
| C | LYS158 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 621 |
| Chain | Residue |
| A | TYR293 |
| A | ARG7 |
| A | SER9 |
| A | ALA18 |
| A | TYR20 |
| site_id | CC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 622 |
| Chain | Residue |
| A | ARG384 |
| A | GLN386 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 623 |
| Chain | Residue |
| A | ASP243 |
| A | ASP347 |
| A | GLU348 |
| A | SER392 |
| A | HOH756 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 2TU B 601 |
| Chain | Residue |
| B | THR309 |
| B | ASN312 |
| B | TYR344 |
| B | GLY345 |
| B | ASP346 |
| B | HOH821 |
| site_id | CC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 602 |
| Chain | Residue |
| B | HIS149 |
| B | ASN152 |
| site_id | CC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 603 |
| Chain | Residue |
| B | GLN83 |
| B | HOH763 |
| site_id | CC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 604 |
| Chain | Residue |
| A | ILE334 |
| B | ARG329 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 605 |
| Chain | Residue |
| B | ASP410 |
| B | ARG411 |
| B | HIS453 |
| B | HOH867 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 606 |
| Chain | Residue |
| A | LYS158 |
| B | LYS29 |
| B | HIS426 |
| B | GLN427 |
| B | GLU431 |
| site_id | DC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 607 |
| Chain | Residue |
| B | CYS90 |
| B | ASP91 |
| B | GLU94 |
| B | ARG260 |
| B | ASP263 |
| B | ILE264 |
| B | ARG267 |
| site_id | DC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 608 |
| Chain | Residue |
| B | SER223 |
| B | MET224 |
| B | ASN225 |
| site_id | DC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 609 |
| Chain | Residue |
| B | ARG385 |
| B | GLN386 |
| B | THR387 |
| site_id | DC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 610 |
| Chain | Residue |
| B | ASP117 |
| B | THR120 |
| B | LYS130 |
| B | MET195 |
| site_id | DC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 611 |
| Chain | Residue |
| B | THR28 |
| B | SER52 |
| B | SER61 |
| B | LEU62 |
| B | GLN63 |
| B | HOH833 |
| site_id | DC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 612 |
| Chain | Residue |
| B | GLY157 |
| B | LYS158 |
| B | SER159 |
| site_id | DC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 613 |
| Chain | Residue |
| B | PHE109 |
| B | LYS110 |
| B | CYS113 |
| B | ALA138 |
| B | PHE139 |
| site_id | EC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 614 |
| Chain | Residue |
| B | SER121 |
| B | GLY123 |
| B | HIS127 |
| B | THR165 |
| B | GLY189 |
| B | SER190 |
| site_id | EC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 615 |
| Chain | Residue |
| B | ASN237 |
| B | PHE238 |
| B | ARG239 |
| C | ALA236 |
| C | ASN237 |
| C | PHE238 |
| site_id | EC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 616 |
| Chain | Residue |
| B | THR108 |
| B | PHE109 |
| B | LYS110 |
| B | ASN151 |
| B | GLU155 |
| B | ARG200 |
| site_id | EC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 617 |
| Chain | Residue |
| B | ASP243 |
| B | ASP245 |
| B | ASP346 |
| B | ASP347 |
| B | GLU348 |
| B | HOH865 |
| site_id | EC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 2TU C 601 |
| Chain | Residue |
| C | ASP250 |
| C | SER303 |
| C | THR308 |
| C | THR309 |
| C | ASN312 |
| C | GLY345 |
| C | ASP346 |
| C | HOH846 |
| site_id | EC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 602 |
| Chain | Residue |
| C | TYR246 |
| C | THR247 |
| C | ARG248 |
| C | HOH721 |
| site_id | EC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 603 |
| Chain | Residue |
| C | HIS149 |
| C | ASN152 |
| site_id | EC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 604 |
| Chain | Residue |
| C | ARG374 |
| C | GLU383 |
| C | ARG385 |
| site_id | EC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 605 |
| Chain | Residue |
| C | GLY454 |
| C | GLU455 |
| C | LYS456 |
| site_id | FC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 606 |
| Chain | Residue |
| C | THR11 |
| C | TYR12 |
| C | ALA13 |
| site_id | FC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 607 |
| Chain | Residue |
| C | ASN95 |
| C | ASN99 |
| site_id | FC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 608 |
| Chain | Residue |
| C | TRP134 |
| C | GLY136 |
| site_id | FC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 609 |
| Chain | Residue |
| C | THR28 |
| C | GLY51 |
| C | SER52 |
| C | SER61 |
| C | LEU62 |
| C | HOH789 |
| site_id | FC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 610 |
| Chain | Residue |
| C | LEU168 |
| C | LYS169 |
| C | ASP170 |
| C | LEU187 |
| site_id | FC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 611 |
| Chain | Residue |
| B | ASN237 |
| C | ASP401 |
| C | TRP405 |
| C | HOH793 |
| site_id | FC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 612 |
| Chain | Residue |
| C | ASP410 |
| C | ARG411 |
| C | HIS453 |
| C | HOH783 |
| site_id | FC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 613 |
| Chain | Residue |
| C | PHE109 |
| C | CYS113 |
| C | ALA138 |
| C | PHE139 |
| site_id | FC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL C 614 |
| Chain | Residue |
| C | SER27 |
| C | LYS29 |
| C | ASN425 |
| site_id | GC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 615 |
| Chain | Residue |
| C | GLY157 |
| C | LYS158 |
| C | SER159 |
| C | HOH833 |
| site_id | GC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL C 616 |
| Chain | Residue |
| C | ARG384 |
| C | ARG385 |
| C | GLN386 |
| site_id | GC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 617 |
| Chain | Residue |
| C | CYS90 |
| C | ASP91 |
| C | GLU94 |
| C | ARG260 |
| C | ILE264 |
| C | ARG267 |
| site_id | GC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 618 |
| Chain | Residue |
| C | HIS426 |
| C | GLN427 |
| C | ASN428 |
| C | GLU431 |
| site_id | GC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 619 |
| Chain | Residue |
| C | ASP243 |
| C | ASP347 |
| C | GLU348 |
| C | SER392 |
| C | HOH743 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21471315, ECO:0000269|PubMed:22341781, ECO:0000269|PubMed:24622391 |
| Chain | Residue | Details |
| A | ASP243 | |
| A | GLU348 | |
| B | ASP243 | |
| B | GLU348 | |
| C | ASP243 | |
| C | GLU348 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21471315 |
| Chain | Residue | Details |
| A | ASP245 | |
| B | ASP245 | |
| C | ASP245 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21471315, ECO:0000269|PubMed:24622391 |
| Chain | Residue | Details |
| A | ASP347 | |
| B | ASP347 | |
| C | ASP347 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22341781, ECO:0000269|PubMed:24622391 |
| Chain | Residue | Details |
| A | SER392 | |
| B | SER392 | |
| C | SER392 |
