3SBA

Zn-mediated Hexamer of T4 Lysozyme R76H/R80H by Synthetic Symmetrization

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0009253	biological_process	peptidoglycan catabolic process
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0030430	cellular_component	host cell cytoplasm
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis
B	0003796	molecular_function	lysozyme activity
B	0009253	biological_process	peptidoglycan catabolic process
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0016998	biological_process	cell wall macromolecule catabolic process
B	0030430	cellular_component	host cell cytoplasm
B	0031640	biological_process	killing of cells of another organism
B	0042742	biological_process	defense response to bacterium
B	0044659	biological_process	viral release from host cell by cytolysis
C	0003796	molecular_function	lysozyme activity
C	0009253	biological_process	peptidoglycan catabolic process
C	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
C	0016998	biological_process	cell wall macromolecule catabolic process
C	0030430	cellular_component	host cell cytoplasm
C	0031640	biological_process	killing of cells of another organism
C	0042742	biological_process	defense response to bacterium
C	0044659	biological_process	viral release from host cell by cytolysis
D	0003796	molecular_function	lysozyme activity
D	0009253	biological_process	peptidoglycan catabolic process
D	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
D	0016998	biological_process	cell wall macromolecule catabolic process
D	0030430	cellular_component	host cell cytoplasm
D	0031640	biological_process	killing of cells of another organism
D	0042742	biological_process	defense response to bacterium
D	0044659	biological_process	viral release from host cell by cytolysis
E	0003796	molecular_function	lysozyme activity
E	0009253	biological_process	peptidoglycan catabolic process
E	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
E	0016998	biological_process	cell wall macromolecule catabolic process
E	0030430	cellular_component	host cell cytoplasm
E	0031640	biological_process	killing of cells of another organism
E	0042742	biological_process	defense response to bacterium
E	0044659	biological_process	viral release from host cell by cytolysis
F	0003796	molecular_function	lysozyme activity
F	0009253	biological_process	peptidoglycan catabolic process
F	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
F	0016998	biological_process	cell wall macromolecule catabolic process
F	0030430	cellular_component	host cell cytoplasm
F	0031640	biological_process	killing of cells of another organism
F	0042742	biological_process	defense response to bacterium
F	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 163

Chain	Residue
B	HIS76
B	HIS80
D	HIS76
D	HIS80

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 164

Chain	Residue
B	THR142
B	PRO143
B	ASN144
B	ARG145

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 163

Chain	Residue
C	HIS80
E	HIS76
E	HIS80
C	HIS76

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 163

Chain	Residue
A	HIS76
A	HIS80
F	HIS76
F	HIS80

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	GLU11
B	GLU11
C	GLU11
D	GLU11
E	GLU11
F	GLU11

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	ASP20
B	ASP20
C	ASP20
D	ASP20
E	ASP20
F	ASP20

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	LEU32
E	PHE104
F	LEU32
F	PHE104
A	PHE104
B	LEU32
B	PHE104
C	LEU32
C	PHE104
D	LEU32
D	PHE104
E	LEU32

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: BINDING => ECO:0000303|PubMed:7831309

Chain	Residue	Details
A	SER117
E	ASN132
F	SER117
F	ASN132
A	ASN132
B	SER117
B	ASN132
C	SER117
C	ASN132
D	SER117
D	ASN132
E	SER117

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
A	GLU11	proton shuttle (general acid/base)
A	ASP20	covalent catalysis

---

site_id	MCSA2
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
B	GLU11	proton shuttle (general acid/base)
B	ASP20	covalent catalysis

---

site_id	MCSA3
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
C	GLU11	proton shuttle (general acid/base)
C	ASP20	covalent catalysis

---

site_id	MCSA4
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
D	GLU11	proton shuttle (general acid/base)
D	ASP20	covalent catalysis

---

site_id	MCSA5
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
E	GLU11	proton shuttle (general acid/base)
E	ASP20	covalent catalysis

---

site_id	MCSA6
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
F	GLU11	proton shuttle (general acid/base)
F	ASP20	covalent catalysis

---