3SAO

The Siderocalin Ex-FABP functions through dual ligand specificities

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002062	biological_process	chondrocyte differentiation
A	0002376	biological_process	immune system process
A	0003415	biological_process	chondrocyte hypertrophy
A	0005504	molecular_function	fatty acid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005623	cellular_component	obsolete cell
A	0006629	biological_process	lipid metabolic process
A	0006915	biological_process	apoptotic process
A	0006953	biological_process	acute-phase response
A	0006954	biological_process	inflammatory response
A	0007507	biological_process	heart development
A	0008283	biological_process	cell population proliferation
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009410	biological_process	response to xenobiotic stimulus
A	0009636	biological_process	response to toxic substance
A	0009792	biological_process	embryo development ending in birth or egg hatching
A	0010831	biological_process	positive regulation of myotube differentiation
A	0015908	biological_process	fatty acid transport
A	0015909	biological_process	long-chain fatty acid transport
A	0030154	biological_process	cell differentiation
A	0032332	biological_process	positive regulation of chondrocyte differentiation
A	0032496	biological_process	response to lipopolysaccharide
A	0034097	biological_process	response to cytokine
A	0036094	molecular_function	small molecule binding
A	0042742	biological_process	defense response to bacterium
A	0043066	biological_process	negative regulation of apoptotic process
A	0045087	biological_process	innate immune response
A	0045663	biological_process	positive regulation of myoblast differentiation
A	0050544	molecular_function	arachidonate binding
A	0051412	biological_process	response to corticosterone
A	0055001	biological_process	muscle cell development
A	0055089	biological_process	fatty acid homeostasis
A	0070538	molecular_function	oleic acid binding
A	0070539	molecular_function	linoleic acid binding
A	0070540	molecular_function	stearic acid binding
A	0070543	biological_process	response to linoleic acid
A	0071399	biological_process	cellular response to linoleic acid
B	0002062	biological_process	chondrocyte differentiation
B	0002376	biological_process	immune system process
B	0003415	biological_process	chondrocyte hypertrophy
B	0005504	molecular_function	fatty acid binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005623	cellular_component	obsolete cell
B	0006629	biological_process	lipid metabolic process
B	0006915	biological_process	apoptotic process
B	0006953	biological_process	acute-phase response
B	0006954	biological_process	inflammatory response
B	0007507	biological_process	heart development
B	0008283	biological_process	cell population proliferation
B	0008284	biological_process	positive regulation of cell population proliferation
B	0009410	biological_process	response to xenobiotic stimulus
B	0009636	biological_process	response to toxic substance
B	0009792	biological_process	embryo development ending in birth or egg hatching
B	0010831	biological_process	positive regulation of myotube differentiation
B	0015908	biological_process	fatty acid transport
B	0015909	biological_process	long-chain fatty acid transport
B	0030154	biological_process	cell differentiation
B	0032332	biological_process	positive regulation of chondrocyte differentiation
B	0032496	biological_process	response to lipopolysaccharide
B	0034097	biological_process	response to cytokine
B	0036094	molecular_function	small molecule binding
B	0042742	biological_process	defense response to bacterium
B	0043066	biological_process	negative regulation of apoptotic process
B	0045087	biological_process	innate immune response
B	0045663	biological_process	positive regulation of myoblast differentiation
B	0050544	molecular_function	arachidonate binding
B	0051412	biological_process	response to corticosterone
B	0055001	biological_process	muscle cell development
B	0055089	biological_process	fatty acid homeostasis
B	0070538	molecular_function	oleic acid binding
B	0070539	molecular_function	linoleic acid binding
B	0070540	molecular_function	stearic acid binding
B	0070543	biological_process	response to linoleic acid
B	0071399	biological_process	cellular response to linoleic acid

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NKN A 161

Chain	Residue
A	ILE38
A	TYR50
A	PHE65
A	LYS82
A	ILE97
A	ARG112
A	TYR114

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NKN B 161

Chain	Residue
B	TYR75
B	LYS82
B	VAL84
B	ILE97
B	ARG112
B	TYR114
B	LEU46
B	TYR50

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE DBH B 162

Chain	Residue
B	THR21
B	LYS82
B	ALA99
B	ARG101
B	LEU108
B	HIS109
B	MET110
B	ARG112
B	FE163

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE B 163

Chain	Residue
B	LYS82
B	ARG101
B	ARG112
B	DBH162

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 164

Chain	Residue
B	GLU45
B	THR64
B	TYR76
B	SER77
B	GLU78
B	GLU79
B	HOH216

---

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	12
Details	LIPOCALIN Lipocalin signature. DRS..EVAGKWYIV

Chain	Residue	Details
A	ASP4-VAL15

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22153502","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3SAO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22153502","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SAO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---