3S9M
Complex between transferrin receptor 1 and transferrin with iron in the N-Lobe, cryocooled 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004998 | molecular_function | transferrin receptor activity |
| A | 0033572 | biological_process | transferrin transport |
| B | 0004998 | molecular_function | transferrin receptor activity |
| B | 0033572 | biological_process | transferrin transport |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0005768 | cellular_component | endosome |
| C | 0005769 | cellular_component | early endosome |
| C | 0005770 | cellular_component | late endosome |
| C | 0005788 | cellular_component | endoplasmic reticulum lumen |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0005905 | cellular_component | clathrin-coated pit |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006826 | biological_process | iron ion transport |
| C | 0006879 | biological_process | intracellular iron ion homeostasis |
| C | 0007166 | biological_process | cell surface receptor signaling pathway |
| C | 0008198 | molecular_function | ferrous iron binding |
| C | 0008199 | molecular_function | ferric iron binding |
| C | 0009617 | biological_process | response to bacterium |
| C | 0009925 | cellular_component | basal plasma membrane |
| C | 0009986 | cellular_component | cell surface |
| C | 0010008 | cellular_component | endosome membrane |
| C | 0016020 | cellular_component | membrane |
| C | 0016324 | cellular_component | apical plasma membrane |
| C | 0019731 | biological_process | antibacterial humoral response |
| C | 0019899 | molecular_function | enzyme binding |
| C | 0030139 | cellular_component | endocytic vesicle |
| C | 0030316 | biological_process | osteoclast differentiation |
| C | 0030669 | cellular_component | clathrin-coated endocytic vesicle membrane |
| C | 0031410 | cellular_component | cytoplasmic vesicle |
| C | 0031647 | biological_process | regulation of protein stability |
| C | 0031982 | cellular_component | vesicle |
| C | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| C | 0034774 | cellular_component | secretory granule lumen |
| C | 0034986 | molecular_function | iron chaperone activity |
| C | 0044325 | molecular_function | transmembrane transporter binding |
| C | 0045178 | cellular_component | basal part of cell |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0048260 | biological_process | positive regulation of receptor-mediated endocytosis |
| C | 0048471 | cellular_component | perinuclear region of cytoplasm |
| C | 0055037 | cellular_component | recycling endosome |
| C | 0060586 | biological_process | multicellular organismal-level iron ion homeostasis |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0071281 | biological_process | cellular response to iron ion |
| C | 0072562 | cellular_component | blood microparticle |
| C | 1903988 | biological_process | iron ion export across plasma membrane |
| C | 1990459 | molecular_function | transferrin receptor binding |
| C | 1990712 | cellular_component | HFE-transferrin receptor complex |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0005768 | cellular_component | endosome |
| D | 0005769 | cellular_component | early endosome |
| D | 0005770 | cellular_component | late endosome |
| D | 0005788 | cellular_component | endoplasmic reticulum lumen |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0005905 | cellular_component | clathrin-coated pit |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006826 | biological_process | iron ion transport |
| D | 0006879 | biological_process | intracellular iron ion homeostasis |
| D | 0007166 | biological_process | cell surface receptor signaling pathway |
| D | 0008198 | molecular_function | ferrous iron binding |
| D | 0008199 | molecular_function | ferric iron binding |
| D | 0009617 | biological_process | response to bacterium |
| D | 0009925 | cellular_component | basal plasma membrane |
| D | 0009986 | cellular_component | cell surface |
| D | 0010008 | cellular_component | endosome membrane |
| D | 0016020 | cellular_component | membrane |
| D | 0016324 | cellular_component | apical plasma membrane |
| D | 0019731 | biological_process | antibacterial humoral response |
| D | 0019899 | molecular_function | enzyme binding |
| D | 0030139 | cellular_component | endocytic vesicle |
| D | 0030316 | biological_process | osteoclast differentiation |
| D | 0030669 | cellular_component | clathrin-coated endocytic vesicle membrane |
| D | 0031410 | cellular_component | cytoplasmic vesicle |
| D | 0031647 | biological_process | regulation of protein stability |
| D | 0031982 | cellular_component | vesicle |
| D | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| D | 0034774 | cellular_component | secretory granule lumen |
| D | 0034986 | molecular_function | iron chaperone activity |
| D | 0044325 | molecular_function | transmembrane transporter binding |
| D | 0045178 | cellular_component | basal part of cell |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0048260 | biological_process | positive regulation of receptor-mediated endocytosis |
| D | 0048471 | cellular_component | perinuclear region of cytoplasm |
| D | 0055037 | cellular_component | recycling endosome |
| D | 0060586 | biological_process | multicellular organismal-level iron ion homeostasis |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0071281 | biological_process | cellular response to iron ion |
| D | 0072562 | cellular_component | blood microparticle |
| D | 1903988 | biological_process | iron ion export across plasma membrane |
| D | 1990459 | molecular_function | transferrin receptor binding |
| D | 1990712 | cellular_component | HFE-transferrin receptor complex |
Functional Information from PROSITE/UniProt
| site_id | PS00205 |
| Number of Residues | 10 |
| Details | TRANSFERRIN_LIKE_1 Transferrin-like domain signature 1. YyAVAVVKKD |
| Chain | Residue | Details |
| C | TYR95-ASP104 |
| site_id | PS00206 |
| Number of Residues | 17 |
| Details | TRANSFERRIN_LIKE_2 Transferrin-like domain signature 2. YsGAFKCLkdgaGDVAF |
| Chain | Residue | Details |
| C | TYR188-PHE204 |
| site_id | PS00207 |
| Number of Residues | 31 |
| Details | TRANSFERRIN_LIKE_3 Transferrin-like domain signature 3. QYeLLClDntrkp...VdeykdChlAqvpsHtVV |
| Chain | Residue | Details |
| C | GLN222-VAL252 | |
| C | ASP558-VAL588 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 180 |
| Details | Domain: {"description":"PA"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Motif: {"description":"Cell attachment site; required for binding to transferrin"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10531064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CX8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10531064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CX8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000173","evidences":[{"source":"PubMed","id":"10531064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7780197","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CX8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 322 |
| Details | Domain: {"description":"Transferrin-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22327295","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V83","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22327295","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22343719","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31636418","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V83","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SOY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SOZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Dimethylated arginine","evidences":[{"source":"UniProtKB","id":"P12346","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"O-linked (GalNAc...) serine","featureId":"CAR_000073"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","featureId":"CAR_000074","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15084671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15536627","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22327295","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31636418","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SOY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SOZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","featureId":"CAR_000075","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15084671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15536627","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22327295","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
