3S8P
Crystal Structure of the SET Domain of Human Histone-Lysine N-Methyltransferase SUV420H1 In Complex With S-Adenosyl-L-Methionine
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 400 |
| Chain | Residue |
| A | CYS275 |
| A | CYS319 |
| A | CYS321 |
| A | CYS324 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SAM A 500 |
| Chain | Residue |
| A | GLY209 |
| A | ALA210 |
| A | PHE250 |
| A | ALA269 |
| A | PHE270 |
| A | ILE271 |
| A | ASN272 |
| A | HIS273 |
| A | TYR307 |
| A | PHE312 |
| A | CYS319 |
| A | GLU320 |
| A | CYS321 |
| A | HOH436 |
| B | ARG257 |
| A | HOH31 |
| A | HIS98 |
| A | TYR203 |
| A | SER205 |
| A | GLU206 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 400 |
| Chain | Residue |
| B | CYS275 |
| B | CYS319 |
| B | CYS321 |
| B | CYS324 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE SAM B 500 |
| Chain | Residue |
| A | ARG257 |
| A | HOH352 |
| B | HOH14 |
| B | HOH52 |
| B | HIS98 |
| B | TYR203 |
| B | SER205 |
| B | GLU206 |
| B | GLY209 |
| B | ALA210 |
| B | PHE250 |
| B | ALA269 |
| B | PHE270 |
| B | ILE271 |
| B | ASN272 |
| B | HIS273 |
| B | TYR307 |
| B | PHE312 |
| B | CYS319 |
| B | GLU320 |
| B | CYS321 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24396869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28114273","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2017","submissionDatabase":"PDB data bank","title":"Crystal Structure of the SET Domain of Human SUV420H1 In Complex With Inhibitor.","authors":["Halabelian L.","Tempel W.","Brown P.J.","Bountra C.","Edwards A.M.","Arrowsmith C.H."]}},{"source":"PDB","id":"3S8P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CPR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WBV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24396869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28114273","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3S8P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CPR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
