3S8P
Crystal Structure of the SET Domain of Human Histone-Lysine N-Methyltransferase SUV420H1 In Complex With S-Adenosyl-L-Methionine
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 400 |
| Chain | Residue |
| A | CYS275 |
| A | CYS319 |
| A | CYS321 |
| A | CYS324 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SAM A 500 |
| Chain | Residue |
| A | GLY209 |
| A | ALA210 |
| A | PHE250 |
| A | ALA269 |
| A | PHE270 |
| A | ILE271 |
| A | ASN272 |
| A | HIS273 |
| A | TYR307 |
| A | PHE312 |
| A | CYS319 |
| A | GLU320 |
| A | CYS321 |
| A | HOH436 |
| B | ARG257 |
| A | HOH31 |
| A | HIS98 |
| A | TYR203 |
| A | SER205 |
| A | GLU206 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 400 |
| Chain | Residue |
| B | CYS275 |
| B | CYS319 |
| B | CYS321 |
| B | CYS324 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE SAM B 500 |
| Chain | Residue |
| A | ARG257 |
| A | HOH352 |
| B | HOH14 |
| B | HOH52 |
| B | HIS98 |
| B | TYR203 |
| B | SER205 |
| B | GLU206 |
| B | GLY209 |
| B | ALA210 |
| B | PHE250 |
| B | ALA269 |
| B | PHE270 |
| B | ILE271 |
| B | ASN272 |
| B | HIS273 |
| B | TYR307 |
| B | PHE312 |
| B | CYS319 |
| B | GLU320 |
| B | CYS321 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273, ECO:0000269|Ref.14, ECO:0007744|PDB:3S8P, ECO:0007744|PDB:5CPR, ECO:0007744|PDB:5WBV |
| Chain | Residue | Details |
| A | CYS324 | |
| B | HIS98 | |
| B | TYR203 | |
| B | ALA210 | |
| B | ASN272 | |
| B | CYS275 | |
| B | CYS319 | |
| B | GLU320 | |
| B | CYS321 | |
| B | CYS324 | |
| A | HIS98 | |
| A | TYR203 | |
| A | ALA210 | |
| A | ASN272 | |
| A | CYS275 | |
| A | CYS319 | |
| A | GLU320 | |
| A | CYS321 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273, ECO:0007744|PDB:3S8P, ECO:0007744|PDB:5CPR |
| Chain | Residue | Details |
| A | ARG257 | |
| B | ARG257 |
