3S4Y
Crystal structure of human thiamin pyrophosphokinase 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004788 | molecular_function | thiamine diphosphokinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006772 | biological_process | thiamine metabolic process |
| A | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| A | 0010510 | biological_process | regulation of pyruvate decarboxylation to acetyl-CoA |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030975 | molecular_function | thiamine binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0141200 | molecular_function | UTP thiamine diphosphokinase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004788 | molecular_function | thiamine diphosphokinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006772 | biological_process | thiamine metabolic process |
| B | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| B | 0010510 | biological_process | regulation of pyruvate decarboxylation to acetyl-CoA |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030975 | molecular_function | thiamine binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0141200 | molecular_function | UTP thiamine diphosphokinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE TPP A 1301 |
| Chain | Residue |
| A | ASP71 |
| A | HOH327 |
| A | SO41302 |
| A | CA1303 |
| B | TRP202 |
| B | SER216 |
| B | THR217 |
| B | SER218 |
| B | ASN219 |
| A | ASP73 |
| A | GLN96 |
| A | ASP97 |
| A | HIS98 |
| A | THR99 |
| A | ASP100 |
| A | ARG131 |
| A | GLN134 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1302 |
| Chain | Residue |
| A | ASN25 |
| A | ALA45 |
| A | ASP46 |
| A | GLY47 |
| A | ASP73 |
| A | SER74 |
| A | ASP100 |
| A | GLN134 |
| A | HOH308 |
| A | HOH317 |
| A | TPP1301 |
| A | CA1303 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1303 |
| Chain | Residue |
| A | ASP46 |
| A | ASP71 |
| A | ASP73 |
| A | ASP100 |
| A | TPP1301 |
| A | SO41302 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE TPP B 1301 |
| Chain | Residue |
| A | TRP202 |
| A | SER216 |
| A | THR217 |
| A | SER218 |
| A | ASN219 |
| B | ASP71 |
| B | ASP73 |
| B | GLN96 |
| B | ASP97 |
| B | HIS98 |
| B | THR99 |
| B | ASP100 |
| B | ARG131 |
| B | GLN134 |
| B | HOH347 |
| B | HOH362 |
| B | SO41302 |
| B | CA1303 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1302 |
| Chain | Residue |
| B | ASN25 |
| B | ASP46 |
| B | GLY47 |
| B | ASP73 |
| B | SER74 |
| B | ASP100 |
| B | HOH339 |
| B | TPP1301 |
| B | CA1303 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1303 |
| Chain | Residue |
| B | ASP46 |
| B | ASP71 |
| B | ASP73 |
| B | ASP100 |
| B | TPP1301 |
| B | SO41302 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 244 |
| Chain | Residue |
| A | GLY58 |
| A | GLU59 |
| A | ARG60 |
| A | HOH384 |
| A | HOH385 |
| A | HOH386 |
| B | HIS34 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 244 |
| Chain | Residue |
| A | HIS34 |
| B | GLY58 |
| B | GLU59 |
| B | ARG60 |
| B | HOH297 |
| B | HOH299 |
| B | HOH320 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 245 |
| Chain | Residue |
| A | HOH387 |
| B | HIS34 |
| B | ASN37 |
| B | HOH351 |
