3S48

Human Alpha-Haemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004601	molecular_function	peroxidase activity
C	0005344	molecular_function	oxygen carrier activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005829	cellular_component	cytosol
C	0005833	cellular_component	hemoglobin complex
C	0015670	biological_process	carbon dioxide transport
C	0015671	biological_process	oxygen transport
C	0016020	cellular_component	membrane
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0030185	biological_process	nitric oxide transport
C	0031720	molecular_function	haptoglobin binding
C	0031838	cellular_component	haptoglobin-hemoglobin complex
C	0042542	biological_process	response to hydrogen peroxide
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0043177	molecular_function	organic acid binding
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	0071682	cellular_component	endocytic vesicle lumen
C	0072562	cellular_component	blood microparticle
C	0098869	biological_process	cellular oxidant detoxification
D	0004601	molecular_function	peroxidase activity
D	0005344	molecular_function	oxygen carrier activity
D	0005506	molecular_function	iron ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005829	cellular_component	cytosol
D	0005833	cellular_component	hemoglobin complex
D	0015670	biological_process	carbon dioxide transport
D	0015671	biological_process	oxygen transport
D	0016020	cellular_component	membrane
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0030185	biological_process	nitric oxide transport
D	0031720	molecular_function	haptoglobin binding
D	0031838	cellular_component	haptoglobin-hemoglobin complex
D	0042542	biological_process	response to hydrogen peroxide
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0043177	molecular_function	organic acid binding
D	0046872	molecular_function	metal ion binding
D	0070062	cellular_component	extracellular exosome
D	0071682	cellular_component	endocytic vesicle lumen
D	0072562	cellular_component	blood microparticle
D	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HEM D 500

Chain	Residue
D	THR39
D	VAL93
D	ASN97
D	PHE98
D	LEU101
D	HOH501
D	TYR42
D	PHE43
D	HIS58
D	LYS61
D	LEU66
D	LEU83
D	HIS87
D	LEU91

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM C 500

Chain	Residue
A	LYS119
C	TYR42
C	PHE43
C	HIS45
C	HIS58
C	ALA65
C	LEU66
C	LEU83
C	HIS87
C	LEU91
C	VAL93
C	ASN97
C	PHE98
C	LEU101
C	LEU136
C	HOH501

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00238

Chain	Residue	Details
D	HIS58
C	HIS58

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: proximal binding residue => ECO:0000255|PROSITE-ProRule:PRU00238

Chain	Residue	Details
D	HIS87
C	HIS87

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	SITE: (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433

Chain	Residue	Details
D	THR8
D	LEU91
D	LEU106
D	THR108
D	VAL121
D	SER133
C	THR8
C	ALA13
C	TYR24
C	LEU29
C	HIS45
D	ALA13
C	ASP47
C	SER52
C	VAL55
C	GLY59
C	LEU91
C	LEU106
C	THR108
C	VAL121
C	SER133
D	TYR24
D	LEU29
D	HIS45
D	ASP47
D	SER52
D	VAL55
D	GLY59

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	SITE: Not glycated => ECO:0000269|PubMed:7358733

Chain	Residue	Details
D	LYS11
C	LYS99
D	LYS56
D	LYS60
D	LYS90
D	LYS99
C	LYS11
C	LYS56
C	LYS60
C	LYS90

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
D	SER3
D	SER35
D	SER49
C	SER3
C	SER35
C	SER49

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P01942

Chain	Residue	Details
D	LYS7
D	LYS16
D	LYS40
C	LYS7
C	LYS16
C	LYS40

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
D	THR8
C	THR8

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P01942

Chain	Residue	Details
D	LYS11
C	LYS11

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
D	TYR24
C	TYR24

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P01942

Chain	Residue	Details
D	SER102
D	SER124
D	SER131
D	SER138
C	SER102
C	SER124
C	SER131
C	SER138

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P01942

Chain	Residue	Details
D	THR108
D	THR134
D	THR137
C	THR108
C	THR134
C	THR137

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733

Chain	Residue	Details
D	LYS7
D	LYS16
D	LYS40
C	LYS7
C	LYS16
C	LYS40

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733

Chain	Residue	Details
D	LYS61
C	LYS61

---