3S24
Crystal structure of human mRNA guanylyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| B | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| C | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| D | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| E | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| F | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| G | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0006370 | biological_process | 7-methylguanosine mRNA capping |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1 |
| Chain | Residue |
| A | GLN272 |
| A | ARG452 |
| A | ALA538 |
| A | ASN540 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2 |
| Chain | Residue |
| A | GLN272 |
| A | ARG315 |
| A | ASN537 |
| A | ALA538 |
| A | THR541 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 3 |
| Chain | Residue |
| A | GLY297 |
| A | THR298 |
| A | ARG299 |
| A | ARG315 |
| A | ARG530 |
| A | LYS533 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 4 |
| Chain | Residue |
| B | ASN537 |
| B | ALA538 |
| B | THR541 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 5 |
| Chain | Residue |
| A | LYS294 |
| A | ASP296 |
| A | ASP438 |
| A | LYS458 |
| A | LYS460 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 392 |
| Details | Region: {"description":"Interaction with POLR2A","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Active site: {"description":"N6-GMP-lysine intermediate","evidences":[{"source":"PubMed","id":"21636784","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 70 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
