3S24
Crystal structure of human mRNA guanylyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| B | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| C | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| D | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| E | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| F | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| G | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0006370 | biological_process | 7-methylguanosine mRNA capping |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1 |
| Chain | Residue |
| A | GLN272 |
| A | ARG452 |
| A | ALA538 |
| A | ASN540 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2 |
| Chain | Residue |
| A | GLN272 |
| A | ARG315 |
| A | ASN537 |
| A | ALA538 |
| A | THR541 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 3 |
| Chain | Residue |
| A | GLY297 |
| A | THR298 |
| A | ARG299 |
| A | ARG315 |
| A | ARG530 |
| A | LYS533 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 4 |
| Chain | Residue |
| B | ASN537 |
| B | ALA538 |
| B | THR541 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 5 |
| Chain | Residue |
| A | LYS294 |
| A | ASP296 |
| A | ASP438 |
| A | LYS458 |
| A | LYS460 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | ACT_SITE: N6-GMP-lysine intermediate => ECO:0000269|PubMed:21636784 |
| Chain | Residue | Details |
| A | LYS294 | |
| B | LYS294 | |
| C | LYS294 | |
| D | LYS294 | |
| E | LYS294 | |
| G | LYS294 | |
| F | LYS294 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG299 | |
| B | ARG299 | |
| C | ARG299 | |
| D | ARG299 | |
| E | ARG299 | |
| G | ARG299 | |
| F | ARG299 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG315 | |
| C | ASP343 | |
| C | LYS458 | |
| C | ARG528 | |
| D | ARG315 | |
| D | ASP343 | |
| D | LYS458 | |
| D | ARG528 | |
| E | ARG315 | |
| E | ASP343 | |
| E | LYS458 | |
| A | ASP343 | |
| E | ARG528 | |
| G | ARG315 | |
| G | ASP343 | |
| G | LYS458 | |
| G | ARG528 | |
| F | ARG315 | |
| F | ASP343 | |
| F | LYS458 | |
| F | ARG528 | |
| A | LYS458 | |
| A | ARG528 | |
| B | ARG315 | |
| B | ASP343 | |
| B | LYS458 | |
| B | ARG528 | |
| C | ARG315 |
