3RZI
The structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from mycobacterium tuberculosis cocrystallized and complexed with phenylalanine and tryptophan
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0008652 | biological_process | amino acid biosynthetic process |
A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
A | 0009274 | cellular_component | peptidoglycan-based cell wall |
A | 0009423 | biological_process | chorismate biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0030145 | molecular_function | manganese ion binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0051260 | biological_process | protein homooligomerization |
B | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0008652 | biological_process | amino acid biosynthetic process |
B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
B | 0009274 | cellular_component | peptidoglycan-based cell wall |
B | 0009423 | biological_process | chorismate biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
B | 0030145 | molecular_function | manganese ion binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0051260 | biological_process | protein homooligomerization |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN A 463 |
Chain | Residue |
A | CYS87 |
A | HIS369 |
A | GLU411 |
A | ASP441 |
A | HOH567 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PHE A 464 |
Chain | Residue |
A | HOH487 |
A | HOH599 |
B | VAL5 |
A | PHE91 |
A | ARG171 |
A | ALA174 |
A | ASN175 |
site_id | AC3 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE TRP A 465 |
Chain | Residue |
A | LEU107 |
A | VAL111 |
A | LYS123 |
A | ALA192 |
A | LEU194 |
A | CYS231 |
A | ASN237 |
A | LEU238 |
A | THR240 |
A | ALA241 |
A | GOL469 |
A | HOH496 |
A | HOH514 |
A | HOH633 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PO4 A 466 |
Chain | Residue |
A | GLY282 |
A | GLU283 |
A | LYS306 |
A | ARG337 |
A | HIS369 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 467 |
Chain | Residue |
A | THR39 |
A | ARG145 |
A | ARG148 |
A | HIS164 |
A | HOH528 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 468 |
Chain | Residue |
A | GLU63 |
A | THR187 |
A | GLU242 |
A | ILE243 |
A | TYR244 |
A | HOH664 |
site_id | AC7 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 469 |
Chain | Residue |
A | GLN70 |
A | VAL121 |
A | VAL122 |
A | LYS123 |
A | GLU242 |
A | TRP465 |
A | HOH496 |
A | HOH592 |
site_id | AC8 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE CL A 470 |
Chain | Residue |
A | GLN36 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 471 |
Chain | Residue |
A | ARG135 |
A | SER136 |
A | ALA137 |
A | ARG284 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN B 463 |
Chain | Residue |
B | CYS87 |
B | HIS369 |
B | GLU411 |
B | ASP441 |
B | HOH533 |
site_id | BC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL B 464 |
Chain | Residue |
B | LEU30 |
B | ASP253 |
B | ARG256 |
site_id | BC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PHE B 465 |
Chain | Residue |
A | VAL55 |
A | TYR173 |
A | HOH616 |
B | PHE91 |
B | ARG171 |
B | ALA174 |
B | ASN175 |
B | HOH598 |
site_id | BC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE TRP B 466 |
Chain | Residue |
B | VAL111 |
B | LYS123 |
B | ALA192 |
B | LEU194 |
B | ASN237 |
B | LEU238 |
B | THR240 |
B | ALA241 |
B | HOH510 |
B | HOH560 |
B | HOH584 |
B | HOH694 |
site_id | BC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 B 467 |
Chain | Residue |
B | GLY282 |
B | GLU283 |
B | LYS306 |
B | ARG337 |
B | HOH593 |
B | HOH635 |
B | HOH651 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 468 |
Chain | Residue |
B | ARG135 |
B | SER136 |
B | ALA137 |
B | ARG284 |
B | HOH727 |
site_id | BC7 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 B 469 |
Chain | Residue |
B | ASP158 |
B | ALA159 |
B | HOH480 |
B | HOH634 |
B | PRO17 |
B | LEU18 |
B | ARG23 |
B | LEU144 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 470 |
Chain | Residue |
B | ARG23 |
B | ARG256 |
B | HOH562 |
B | HOH606 |
site_id | BC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 472 |
Chain | Residue |
A | ARG23 |
A | THR24 |
A | ASP27 |
B | GLN297 |
B | ARG322 |
B | HOH487 |
B | HOH537 |
site_id | CC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 473 |
Chain | Residue |
B | MET180 |
B | THR187 |
B | GLU242 |
B | ILE243 |
B | HIS277 |
site_id | CC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 474 |
Chain | Residue |
B | MET92 |
B | ASP93 |
B | PHE155 |
B | GLU437 |
B | HOH540 |
site_id | CC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL B 475 |
Chain | Residue |
B | GLN70 |
B | PRO120 |
B | VAL121 |
B | GLU242 |
B | HOH510 |
B | HOH511 |
B | HOH535 |
B | HOH584 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16288916, ECO:0007744|PDB:2B7O |
Chain | Residue | Details |
A | CYS87 | |
B | ARG126 | |
B | GLU283 | |
B | LYS306 | |
B | ARG337 | |
B | HIS369 | |
B | GLU411 | |
B | ASP441 | |
A | ARG126 | |
A | GLU283 | |
A | LYS306 | |
A | ARG337 | |
A | HIS369 | |
A | GLU411 | |
A | ASP441 | |
B | CYS87 |