3RZI
The structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from mycobacterium tuberculosis cocrystallized and complexed with phenylalanine and tryptophan
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051260 | biological_process | protein homooligomerization |
| B | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051260 | biological_process | protein homooligomerization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 463 |
| Chain | Residue |
| A | CYS87 |
| A | HIS369 |
| A | GLU411 |
| A | ASP441 |
| A | HOH567 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PHE A 464 |
| Chain | Residue |
| A | HOH487 |
| A | HOH599 |
| B | VAL5 |
| A | PHE91 |
| A | ARG171 |
| A | ALA174 |
| A | ASN175 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TRP A 465 |
| Chain | Residue |
| A | LEU107 |
| A | VAL111 |
| A | LYS123 |
| A | ALA192 |
| A | LEU194 |
| A | CYS231 |
| A | ASN237 |
| A | LEU238 |
| A | THR240 |
| A | ALA241 |
| A | GOL469 |
| A | HOH496 |
| A | HOH514 |
| A | HOH633 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 466 |
| Chain | Residue |
| A | GLY282 |
| A | GLU283 |
| A | LYS306 |
| A | ARG337 |
| A | HIS369 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 467 |
| Chain | Residue |
| A | THR39 |
| A | ARG145 |
| A | ARG148 |
| A | HIS164 |
| A | HOH528 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 468 |
| Chain | Residue |
| A | GLU63 |
| A | THR187 |
| A | GLU242 |
| A | ILE243 |
| A | TYR244 |
| A | HOH664 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 469 |
| Chain | Residue |
| A | GLN70 |
| A | VAL121 |
| A | VAL122 |
| A | LYS123 |
| A | GLU242 |
| A | TRP465 |
| A | HOH496 |
| A | HOH592 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 470 |
| Chain | Residue |
| A | GLN36 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 471 |
| Chain | Residue |
| A | ARG135 |
| A | SER136 |
| A | ALA137 |
| A | ARG284 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 463 |
| Chain | Residue |
| B | CYS87 |
| B | HIS369 |
| B | GLU411 |
| B | ASP441 |
| B | HOH533 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 464 |
| Chain | Residue |
| B | LEU30 |
| B | ASP253 |
| B | ARG256 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PHE B 465 |
| Chain | Residue |
| A | VAL55 |
| A | TYR173 |
| A | HOH616 |
| B | PHE91 |
| B | ARG171 |
| B | ALA174 |
| B | ASN175 |
| B | HOH598 |
| site_id | BC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE TRP B 466 |
| Chain | Residue |
| B | VAL111 |
| B | LYS123 |
| B | ALA192 |
| B | LEU194 |
| B | ASN237 |
| B | LEU238 |
| B | THR240 |
| B | ALA241 |
| B | HOH510 |
| B | HOH560 |
| B | HOH584 |
| B | HOH694 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 B 467 |
| Chain | Residue |
| B | GLY282 |
| B | GLU283 |
| B | LYS306 |
| B | ARG337 |
| B | HOH593 |
| B | HOH635 |
| B | HOH651 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 468 |
| Chain | Residue |
| B | ARG135 |
| B | SER136 |
| B | ALA137 |
| B | ARG284 |
| B | HOH727 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 469 |
| Chain | Residue |
| B | ASP158 |
| B | ALA159 |
| B | HOH480 |
| B | HOH634 |
| B | PRO17 |
| B | LEU18 |
| B | ARG23 |
| B | LEU144 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 470 |
| Chain | Residue |
| B | ARG23 |
| B | ARG256 |
| B | HOH562 |
| B | HOH606 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 472 |
| Chain | Residue |
| A | ARG23 |
| A | THR24 |
| A | ASP27 |
| B | GLN297 |
| B | ARG322 |
| B | HOH487 |
| B | HOH537 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 473 |
| Chain | Residue |
| B | MET180 |
| B | THR187 |
| B | GLU242 |
| B | ILE243 |
| B | HIS277 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 474 |
| Chain | Residue |
| B | MET92 |
| B | ASP93 |
| B | PHE155 |
| B | GLU437 |
| B | HOH540 |
| site_id | CC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 475 |
| Chain | Residue |
| B | GLN70 |
| B | PRO120 |
| B | VAL121 |
| B | GLU242 |
| B | HOH510 |
| B | HOH511 |
| B | HOH535 |
| B | HOH584 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16288916","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2B7O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
