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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

3RYT

The Plexin A1 intracellular region in complex with Rac1

Functional Information from GO Data
ChainGOidnamespacecontents
A0017154molecular_functionsemaphorin receptor activity
A0071526biological_processsemaphorin-plexin signaling pathway
B0017154molecular_functionsemaphorin receptor activity
B0071526biological_processsemaphorin-plexin signaling pathway
C0000166molecular_functionnucleotide binding
C0000242cellular_componentpericentriolar material
C0001764biological_processneuron migration
C0001891cellular_componentphagocytic cup
C0001934biological_processpositive regulation of protein phosphorylation
C0003376biological_processsphingosine-1-phosphate receptor signaling pathway
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005802cellular_componenttrans-Golgi network
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005884cellular_componentactin filament
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0005938cellular_componentcell cortex
C0006911biological_processphagocytosis, engulfment
C0006954biological_processinflammatory response
C0007015biological_processactin filament organization
C0007155biological_processcell adhesion
C0007160biological_processcell-matrix adhesion
C0007163biological_processestablishment or maintenance of cell polarity
C0007167biological_processenzyme-linked receptor protein signaling pathway
C0007264biological_processsmall GTPase-mediated signal transduction
C0008045biological_processmotor neuron axon guidance
C0008360biological_processregulation of cell shape
C0009611biological_processresponse to wounding
C0009653biological_processanatomical structure morphogenesis
C0010310biological_processregulation of hydrogen peroxide metabolic process
C0010591biological_processregulation of lamellipodium assembly
C0010592biological_processpositive regulation of lamellipodium assembly
C0010595biological_processpositive regulation of endothelial cell migration
C0010762biological_processregulation of fibroblast migration
C0010764biological_processnegative regulation of fibroblast migration
C0010810biological_processregulation of cell-substrate adhesion
C0016020cellular_componentmembrane
C0016477biological_processcell migration
C0016601biological_processRac protein signal transduction
C0016787molecular_functionhydrolase activity
C0019899molecular_functionenzyme binding
C0019901molecular_functionprotein kinase binding
C0030027cellular_componentlamellipodium
C0030031biological_processcell projection assembly
C0030032biological_processlamellipodium assembly
C0030036biological_processactin cytoskeleton organization
C0030041biological_processactin filament polymerization
C0030334biological_processregulation of cell migration
C0030425cellular_componentdendrite
C0030667cellular_componentsecretory granule membrane
C0030672cellular_componentsynaptic vesicle membrane
C0030742molecular_functionGTP-dependent protein binding
C0030865biological_processcortical cytoskeleton organization
C0030900biological_processforebrain development
C0031410cellular_componentcytoplasmic vesicle
C0031529biological_processruffle organization
C0031901cellular_componentearly endosome membrane
C0031996molecular_functionthioesterase binding
C0032496biological_processresponse to lipopolysaccharide
C0032587cellular_componentruffle membrane
C0032707biological_processnegative regulation of interleukin-23 production
C0032956biological_processregulation of actin cytoskeleton organization
C0034446biological_processsubstrate adhesion-dependent cell spreading
C0035025biological_processpositive regulation of Rho protein signal transduction
C0035556biological_processintracellular signal transduction
C0035567biological_processnon-canonical Wnt signaling pathway
C0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0042470cellular_componentmelanosome
C0042554biological_processsuperoxide anion generation
C0042734cellular_componentpresynaptic membrane
C0042995cellular_componentcell projection
C0043020cellular_componentNADPH oxidase complex
C0043652biological_processengulfment of apoptotic cell
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0045428biological_processregulation of nitric oxide biosynthetic process
C0045730biological_processrespiratory burst
C0046425biological_processregulation of receptor signaling pathway via JAK-STAT
C0048012biological_processhepatocyte growth factor receptor signaling pathway
C0048261biological_processnegative regulation of receptor-mediated endocytosis
C0048812biological_processneuron projection morphogenesis
C0048870biological_processcell motility
C0051022molecular_functionRho GDP-dissociation inhibitor binding
C0051492biological_processregulation of stress fiber assembly
C0051496biological_processpositive regulation of stress fiber assembly
C0051668biological_processlocalization within membrane
C0051894biological_processpositive regulation of focal adhesion assembly
C0055038cellular_componentrecycling endosome membrane
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0060091cellular_componentkinocilium
C0060263biological_processregulation of respiratory burst
C0060326biological_processcell chemotaxis
C0061344biological_processregulation of cell adhesion involved in heart morphogenesis
C0070062cellular_componentextracellular exosome
C0071526biological_processsemaphorin-plexin signaling pathway
C0090023biological_processpositive regulation of neutrophil chemotaxis
C0097178biological_processruffle assembly
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0101003cellular_componentficolin-1-rich granule membrane
C0150052biological_processregulation of postsynapse assembly
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
C1900029biological_processpositive regulation of ruffle assembly
C1900242biological_processregulation of synaptic vesicle endocytosis
C1902622biological_processregulation of neutrophil migration
C1903348biological_processpositive regulation of bicellular tight junction assembly
C1904948biological_processmidbrain dopaminergic neuron differentiation
C2000386biological_processpositive regulation of ovarian follicle development
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG C 178
ChainResidue
CTHR17
CTHR35
CASP57
CTHR58
CGNP179
site_idAC2
Number of Residues18
DetailsBINDING SITE FOR RESIDUE GNP C 179
ChainResidue
CLYS16
CTHR17
CCYS18
CPHE28
CGLY30
CTYR32
CPRO34
CTHR35
CLYS116
CASP118
CSER158
CALA159
CLEU160
CMG178
CGLY12
CALA13
CVAL14
CGLY15
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsMotif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8Q0N","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11090627","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38355798","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WEJ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11090627","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q0N","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11090627","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38355798","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WEJ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate","evidences":[{"source":"PubMed","id":"19362538","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"(Microbial infection) O-AMP-threonine; by Vibrio VopS","evidences":[{"source":"PubMed","id":"19039103","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB, and by P.sordellii toxin TcsL; alternate","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7775453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7777059","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"18093184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23512198","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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