3RYH

GMPCPP-Tubulin: RB3 Stathmin-like domain complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005879	cellular_component	axonemal microtubule
A	0005929	cellular_component	cilium
A	0007010	biological_process	cytoskeleton organization
A	0007017	biological_process	microtubule-based process
A	0015630	cellular_component	microtubule cytoskeleton
A	0030317	biological_process	flagellated sperm motility
A	0036126	cellular_component	sperm flagellum
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0042802	molecular_function	identical protein binding
A	0055037	cellular_component	recycling endosome
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005525	molecular_function	GTP binding
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007010	biological_process	cytoskeleton organization
B	0007017	biological_process	microtubule-based process
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005525	molecular_function	GTP binding
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005879	cellular_component	axonemal microtubule
C	0005929	cellular_component	cilium
C	0007010	biological_process	cytoskeleton organization
C	0007017	biological_process	microtubule-based process
C	0015630	cellular_component	microtubule cytoskeleton
C	0030317	biological_process	flagellated sperm motility
C	0036126	cellular_component	sperm flagellum
C	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
C	0042802	molecular_function	identical protein binding
C	0055037	cellular_component	recycling endosome
D	0003924	molecular_function	GTPase activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005525	molecular_function	GTP binding
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0007010	biological_process	cytoskeleton organization
D	0007017	biological_process	microtubule-based process
E	0031110	biological_process	regulation of microtubule polymerization or depolymerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GTP A 600

Chain	Residue
A	GLY10
A	GLY144
A	THR145
A	GLY146
A	VAL177
A	GLU183
A	ASN206
A	TYR224
A	ASN228
A	ILE231
A	MG601
A	GLN11
A	HOH610
A	HOH613
A	HOH614
A	HOH617
B	LYS254
A	ALA12
A	GLN15
A	ASP98
A	ALA99
A	ASN101
A	SER140
A	GLY143

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 601

Chain	Residue
A	GTP600
A	HOH610
A	HOH611
A	HOH612
A	HOH613

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 452

Chain	Residue
A	PRO175
A	LYS394
B	ASN349

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 453

Chain	Residue
A	ARG308
A	ARG339
A	SER340

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 454

Chain	Residue
A	ASN216
A	VAL275
A	HOH648
D	LYS124

---

site_id	AC6
Number of Residues	23
Details	BINDING SITE FOR RESIDUE G2P B 600

Chain	Residue
B	GLY10
B	GLN11
B	CYS12
B	GLN15
B	ALA99
B	ASN101
B	SER140
B	GLY143
B	GLY144
B	THR145
B	GLY146
B	PRO173
B	VAL177
B	GLU183
B	ASN206
B	TYR224
B	ASN228
B	MG601
B	HOH610
B	HOH611
B	HOH612
B	HOH621
B	HOH655

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 601

Chain	Residue
B	G2P600
B	HOH610
B	HOH611

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 456

Chain	Residue
B	THR223
B	GLY225
B	ARG278

---

site_id	AC9
Number of Residues	25
Details	BINDING SITE FOR RESIDUE GTP C 600

Chain	Residue
C	GLY10
C	GLN11
C	ALA12
C	GLN15
C	ASP98
C	ALA99
C	ASN101
C	SER140
C	GLY143
C	GLY144
C	THR145
C	GLY146
C	VAL177
C	GLU183
C	ASN206
C	TYR224
C	ASN228
C	ILE231
C	MG601
C	HOH610
C	HOH611
C	HOH612
C	HOH613
C	HOH626
D	LYS254

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 601

Chain	Residue
C	GTP600
C	HOH610
C	HOH611
C	HOH612
C	HOH613

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 452

Chain	Residue
C	LYS394
D	ASN349
C	PRO175

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 453

Chain	Residue
C	ASP431
C	GLU434
C	VAL435

---

site_id	BC4
Number of Residues	26
Details	BINDING SITE FOR RESIDUE G2P D 600

Chain	Residue
D	GLY10
D	GLN11
D	CYS12
D	GLN15
D	ALA99
D	ASN101
D	SER140
D	GLY143
D	GLY144
D	THR145
D	GLY146
D	PRO173
D	VAL177
D	SER178
D	GLU183
D	ASN206
D	TYR224
D	ASN228
D	MG601
D	HOH610
D	HOH611
D	HOH612
D	HOH613
D	HOH615
D	HOH620
D	HOH647

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 601

Chain	Residue
D	G2P600
D	HOH612
D	HOH613
D	HOH614
D	HOH615

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 456

Chain	Residue
D	THR223
D	ARG278
D	PHE404
D	HOH624

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 457

Chain	Residue
D	HIS229
D	ARG278
D	HOH632

---

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
A	GLY142-GLY148
B	GLY142-GLY148

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

---

site_id	PS00563
Number of Residues	10
Details	STATHMIN_1 Stathmin family signature 1. PRRRDpSLEE

Chain	Residue	Details
E	PRO40-GLU49

---

site_id	PS01041
Number of Residues	10
Details	STATHMIN_2 Stathmin family signature 2. AEKREHEREV

Chain	Residue	Details
E	ALA73-VAL82

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI19
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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