3RWR

Crystal structure of the human XRCC4-XLF complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0005634	cellular_component	nucleus
A	0006302	biological_process	double-strand break repair
A	0006310	biological_process	DNA recombination
B	0003677	molecular_function	DNA binding
B	0005634	cellular_component	nucleus
B	0006302	biological_process	double-strand break repair
B	0006310	biological_process	DNA recombination
D	0005634	cellular_component	nucleus
D	0006302	biological_process	double-strand break repair
E	0005634	cellular_component	nucleus
E	0006302	biological_process	double-strand break repair
F	0003677	molecular_function	DNA binding
F	0005634	cellular_component	nucleus
F	0006302	biological_process	double-strand break repair
F	0006310	biological_process	DNA recombination
G	0003677	molecular_function	DNA binding
G	0005634	cellular_component	nucleus
G	0006302	biological_process	double-strand break repair
G	0006310	biological_process	DNA recombination
H	0005634	cellular_component	nucleus
H	0006302	biological_process	double-strand break repair
I	0005634	cellular_component	nucleus
I	0006302	biological_process	double-strand break repair
J	0003677	molecular_function	DNA binding
J	0005634	cellular_component	nucleus
J	0006302	biological_process	double-strand break repair
J	0006310	biological_process	DNA recombination
K	0003677	molecular_function	DNA binding
K	0005634	cellular_component	nucleus
K	0006302	biological_process	double-strand break repair
K	0006310	biological_process	DNA recombination
L	0005634	cellular_component	nucleus
L	0006302	biological_process	double-strand break repair
M	0005634	cellular_component	nucleus
M	0006302	biological_process	double-strand break repair
N	0003677	molecular_function	DNA binding
N	0005634	cellular_component	nucleus
N	0006302	biological_process	double-strand break repair
N	0006310	biological_process	DNA recombination
O	0005634	cellular_component	nucleus
O	0006302	biological_process	double-strand break repair
P	0003677	molecular_function	DNA binding
P	0005634	cellular_component	nucleus
P	0006302	biological_process	double-strand break repair
P	0006310	biological_process	DNA recombination
Q	0005634	cellular_component	nucleus
Q	0006302	biological_process	double-strand break repair
R	0003677	molecular_function	DNA binding
R	0005634	cellular_component	nucleus
R	0006302	biological_process	double-strand break repair
R	0006310	biological_process	DNA recombination
S	0005634	cellular_component	nucleus
S	0006302	biological_process	double-strand break repair
T	0005634	cellular_component	nucleus
T	0006302	biological_process	double-strand break repair
U	0003677	molecular_function	DNA binding
U	0005634	cellular_component	nucleus
U	0006302	biological_process	double-strand break repair
U	0006310	biological_process	DNA recombination
V	0003677	molecular_function	DNA binding
V	0005634	cellular_component	nucleus
V	0006302	biological_process	double-strand break repair
V	0006310	biological_process	DNA recombination
W	0005634	cellular_component	nucleus
W	0006302	biological_process	double-strand break repair
X	0005634	cellular_component	nucleus
X	0006302	biological_process	double-strand break repair
Y	0003677	molecular_function	DNA binding
Y	0005634	cellular_component	nucleus
Y	0006302	biological_process	double-strand break repair
Y	0006310	biological_process	DNA recombination

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE TBR D 231

Chain	Residue
D	HIS122

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE TBR H 231

Chain	Residue
H	HIS122

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE TBR M 164

Chain	Residue
M	GLU560
M	HIS622

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE TBR J 164

Chain	Residue
J	MET1
J	VAL33
J	THR44
J	GLU125
T	ARG176

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TBR P 2

Chain	Residue
J	TRP155
K	LEU651
K	LEU652
K	ARG653
K	ASP654
K	TRP655
K	ASN656
P	ASP557

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE TBR V 1

Chain	Residue
V	ALA560

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE TBR X 5

Chain	Residue
X	ILE605
X	ARG607
X	HIS622

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE TBR Y 10

Chain	Residue
Y	TYR629
Y	ASP632

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"14599745","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1340
Details	Region: {"description":"Globular head","evidences":[{"source":"PubMed","id":"16571728","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	504
Details	Coiled coil: {"evidences":[{"source":"PubMed","id":"18046455","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Site: {"description":"Leu-lock","evidences":[{"source":"PubMed","id":"21775435","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"18644470","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22228831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28500754","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---