3RWR

Crystal structure of the human XRCC4-XLF complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0005634	cellular_component	nucleus
A	0006302	biological_process	double-strand break repair
A	0006310	biological_process	DNA recombination
B	0003677	molecular_function	DNA binding
B	0005634	cellular_component	nucleus
B	0006302	biological_process	double-strand break repair
B	0006310	biological_process	DNA recombination
D	0005634	cellular_component	nucleus
D	0006302	biological_process	double-strand break repair
E	0005634	cellular_component	nucleus
E	0006302	biological_process	double-strand break repair
F	0003677	molecular_function	DNA binding
F	0005634	cellular_component	nucleus
F	0006302	biological_process	double-strand break repair
F	0006310	biological_process	DNA recombination
G	0003677	molecular_function	DNA binding
G	0005634	cellular_component	nucleus
G	0006302	biological_process	double-strand break repair
G	0006310	biological_process	DNA recombination
H	0005634	cellular_component	nucleus
H	0006302	biological_process	double-strand break repair
I	0005634	cellular_component	nucleus
I	0006302	biological_process	double-strand break repair
J	0003677	molecular_function	DNA binding
J	0005634	cellular_component	nucleus
J	0006302	biological_process	double-strand break repair
J	0006310	biological_process	DNA recombination
K	0003677	molecular_function	DNA binding
K	0005634	cellular_component	nucleus
K	0006302	biological_process	double-strand break repair
K	0006310	biological_process	DNA recombination
L	0005634	cellular_component	nucleus
L	0006302	biological_process	double-strand break repair
M	0005634	cellular_component	nucleus
M	0006302	biological_process	double-strand break repair
N	0003677	molecular_function	DNA binding
N	0005634	cellular_component	nucleus
N	0006302	biological_process	double-strand break repair
N	0006310	biological_process	DNA recombination
O	0005634	cellular_component	nucleus
O	0006302	biological_process	double-strand break repair
P	0003677	molecular_function	DNA binding
P	0005634	cellular_component	nucleus
P	0006302	biological_process	double-strand break repair
P	0006310	biological_process	DNA recombination
Q	0005634	cellular_component	nucleus
Q	0006302	biological_process	double-strand break repair
R	0003677	molecular_function	DNA binding
R	0005634	cellular_component	nucleus
R	0006302	biological_process	double-strand break repair
R	0006310	biological_process	DNA recombination
S	0005634	cellular_component	nucleus
S	0006302	biological_process	double-strand break repair
T	0005634	cellular_component	nucleus
T	0006302	biological_process	double-strand break repair
U	0003677	molecular_function	DNA binding
U	0005634	cellular_component	nucleus
U	0006302	biological_process	double-strand break repair
U	0006310	biological_process	DNA recombination
V	0003677	molecular_function	DNA binding
V	0005634	cellular_component	nucleus
V	0006302	biological_process	double-strand break repair
V	0006310	biological_process	DNA recombination
W	0005634	cellular_component	nucleus
W	0006302	biological_process	double-strand break repair
X	0005634	cellular_component	nucleus
X	0006302	biological_process	double-strand break repair
Y	0003677	molecular_function	DNA binding
Y	0005634	cellular_component	nucleus
Y	0006302	biological_process	double-strand break repair
Y	0006310	biological_process	DNA recombination

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE TBR D 231

Chain	Residue
D	HIS122

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE TBR H 231

Chain	Residue
H	HIS122

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE TBR M 164

Chain	Residue
M	GLU560
M	HIS622

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE TBR J 164

Chain	Residue
J	MET1
J	VAL33
J	THR44
J	GLU125
T	ARG176

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TBR P 2

Chain	Residue
J	TRP155
K	LEU651
K	LEU652
K	ARG653
K	ASP654
K	TRP655
K	ASN656
P	ASP557

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site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE TBR V 1

Chain	Residue
V	ALA560

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE TBR X 5

Chain	Residue
X	ILE605
X	ARG607
X	HIS622

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site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE TBR Y 10

Chain	Residue
Y	TYR629
Y	ASP632

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	SITE: Leu-lock => ECO:0000303|PubMed:21775435

Chain	Residue	Details
D	LEU115
E	LEU615
H	LEU115
I	LEU615
L	LEU115
M	LEU615
O	LEU115
Q	LEU615
S	LEU115
W	LEU615
T	LEU115
X	LEU615

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:28500754

Chain	Residue	Details
D	SER132
D	SER203
E	SER632
E	SER703
H	SER132
H	SER203
I	SER632
I	SER703
L	SER132
L	SER203
M	SER632
M	SER703
O	SER132
O	SER203
Q	SER632
Q	SER703
S	SER132
S	SER203
W	SER632
W	SER703
T	SER132
T	SER203
X	SER632
X	SER703

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