3RW9
Crystal Structure of human Spermidine Synthase in Complex with decarboxylated S-adenosylhomocysteine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004766 | molecular_function | spermidine synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006595 | biological_process | polyamine metabolic process |
| A | 0006596 | biological_process | polyamine biosynthetic process |
| A | 0006597 | biological_process | spermine biosynthetic process |
| A | 0008295 | biological_process | spermidine biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004766 | molecular_function | spermidine synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006595 | biological_process | polyamine metabolic process |
| B | 0006596 | biological_process | polyamine biosynthetic process |
| B | 0006597 | biological_process | spermine biosynthetic process |
| B | 0008295 | biological_process | spermidine biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE DSH A 303 |
| Chain | Residue |
| A | GLN49 |
| A | VAL129 |
| A | GLY154 |
| A | ASP155 |
| A | GLY156 |
| A | ASP173 |
| A | SER174 |
| A | PRO180 |
| A | ALA181 |
| A | SER183 |
| A | LEU184 |
| A | GLN70 |
| A | HOH436 |
| A | GLN80 |
| A | GLY101 |
| A | GLY103 |
| A | ASP104 |
| A | CYS123 |
| A | GLU124 |
| A | ILE125 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE DSH B 303 |
| Chain | Residue |
| B | GLN49 |
| B | GLN70 |
| B | GLN80 |
| B | GLY101 |
| B | GLY103 |
| B | ASP104 |
| B | CYS123 |
| B | GLU124 |
| B | ILE125 |
| B | VAL129 |
| B | GLY154 |
| B | ASP155 |
| B | GLY156 |
| B | ASP173 |
| B | SER174 |
| B | SER175 |
| B | PRO180 |
| B | ALA181 |
| B | SER183 |
| B | LEU184 |
| B | HOH314 |
| B | HOH396 |
Functional Information from PROSITE/UniProt
| site_id | PS01330 |
| Number of Residues | 14 |
| Details | PABS_1 Polyamine biosynthesis (PABS) domain signature. VLIIGGGdGgvLrE |
| Chain | Residue | Details |
| A | VAL97-GLU110 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {} |
| Chain | Residue | Details |
