3RW9

Crystal Structure of human Spermidine Synthase in Complex with decarboxylated S-adenosylhomocysteine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004766	molecular_function	spermidine synthase activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006595	biological_process	polyamine metabolic process
A	0006596	biological_process	polyamine biosynthetic process
A	0006597	biological_process	spermine biosynthetic process
A	0008295	biological_process	spermidine biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
B	0003824	molecular_function	catalytic activity
B	0004766	molecular_function	spermidine synthase activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006595	biological_process	polyamine metabolic process
B	0006596	biological_process	polyamine biosynthetic process
B	0006597	biological_process	spermine biosynthetic process
B	0008295	biological_process	spermidine biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE DSH A 303

Chain	Residue
A	GLN49
A	VAL129
A	GLY154
A	ASP155
A	GLY156
A	ASP173
A	SER174
A	PRO180
A	ALA181
A	SER183
A	LEU184
A	GLN70
A	HOH436
A	GLN80
A	GLY101
A	GLY103
A	ASP104
A	CYS123
A	GLU124
A	ILE125

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site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE DSH B 303

Chain	Residue
B	GLN49
B	GLN70
B	GLN80
B	GLY101
B	GLY103
B	ASP104
B	CYS123
B	GLU124
B	ILE125
B	VAL129
B	GLY154
B	ASP155
B	GLY156
B	ASP173
B	SER174
B	SER175
B	PRO180
B	ALA181
B	SER183
B	LEU184
B	HOH314
B	HOH396

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Functional Information from PROSITE/UniProt

site_id	PS01330
Number of Residues	14
Details	PABS_1 Polyamine biosynthesis (PABS) domain signature. VLIIGGGdGgvLrE

Chain	Residue	Details
A	VAL97-GLU110

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00354","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17585781","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2O07","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17585781","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2O05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O07","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RW9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17585781","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2O0L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17585781","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2O06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17585781","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2O05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RW9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17585781","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2O05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RW9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17585781","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2O05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O07","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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