3RVD
Crystal structure of the binary complex, obtained by soaking, of photosyntetic a4 glyceraldehyde 3-phosphate dehydrogenase (gapdh) with cp12-2, both from arabidopsis thaliana.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006006 | biological_process | glucose metabolic process |
A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
A | 0050661 | molecular_function | NADP binding |
A | 0051287 | molecular_function | NAD binding |
B | 0006006 | biological_process | glucose metabolic process |
B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
B | 0050661 | molecular_function | NADP binding |
B | 0051287 | molecular_function | NAD binding |
C | 0006006 | biological_process | glucose metabolic process |
C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
C | 0050661 | molecular_function | NADP binding |
C | 0051287 | molecular_function | NAD binding |
D | 0006006 | biological_process | glucose metabolic process |
D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
D | 0050661 | molecular_function | NADP binding |
D | 0051287 | molecular_function | NAD binding |
E | 0006006 | biological_process | glucose metabolic process |
E | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
E | 0050661 | molecular_function | NADP binding |
E | 0051287 | molecular_function | NAD binding |
F | 0006006 | biological_process | glucose metabolic process |
F | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
F | 0050661 | molecular_function | NADP binding |
F | 0051287 | molecular_function | NAD binding |
G | 0006006 | biological_process | glucose metabolic process |
G | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
G | 0050661 | molecular_function | NADP binding |
G | 0051287 | molecular_function | NAD binding |
H | 0006006 | biological_process | glucose metabolic process |
H | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
H | 0050661 | molecular_function | NADP binding |
H | 0051287 | molecular_function | NAD binding |
O | 0006006 | biological_process | glucose metabolic process |
O | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
O | 0050661 | molecular_function | NADP binding |
O | 0051287 | molecular_function | NAD binding |
Q | 0006006 | biological_process | glucose metabolic process |
Q | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
Q | 0050661 | molecular_function | NADP binding |
Q | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE NAD A 401 |
Chain | Residue |
A | GLY7 |
A | PHE99 |
A | THR119 |
A | ALA120 |
A | CYS149 |
A | ASN313 |
A | TYR317 |
A | SO4402 |
A | HOH504 |
I | GLU72 |
A | GLY9 |
A | ARG10 |
A | ILE11 |
A | ASP32 |
A | ARG77 |
A | GLY95 |
A | THR96 |
A | GLY97 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 402 |
Chain | Residue |
A | THR179 |
A | ASP181 |
A | ARG195 |
A | ARG231 |
A | NAD401 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 403 |
Chain | Residue |
A | SER148 |
A | THR208 |
A | GLY209 |
A | ALA210 |
A | HOH515 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 404 |
Chain | Residue |
Q | PHE251 |
Q | ALA252 |
Q | VAL299 |
Q | HOH523 |
site_id | AC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 A 405 |
Chain | Residue |
A | ASN256 |
A | ARG260 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 406 |
Chain | Residue |
A | ARG102 |
A | ASP124 |
A | HOH561 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 407 |
Chain | Residue |
A | THR127 |
A | LEU216 |
A | HOH568 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 408 |
Chain | Residue |
A | TYR137 |
A | SER138 |
A | HIS139 |
A | LYS333 |
A | HOH572 |
site_id | AC9 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE NAD B 401 |
Chain | Residue |
B | GLY7 |
B | PHE8 |
B | GLY9 |
B | ARG10 |
B | ILE11 |
B | THR33 |
B | ARG77 |
B | GLY95 |
B | THR96 |
B | GLY97 |
B | PHE99 |
B | THR119 |
B | ALA120 |
B | CYS149 |
B | THR179 |
B | ASN313 |
B | GLU314 |
J | TYR76 |
J | ASP77 |
J | ASN78 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 402 |
Chain | Residue |
B | GLU253 |
B | ASN256 |
B | ARG260 |
B | HOH531 |
B | HOH535 |
site_id | BC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 403 |
Chain | Residue |
B | PRO126 |
B | THR127 |
B | LEU216 |
site_id | BC3 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE NAD C 401 |
Chain | Residue |
C | GLY7 |
C | PHE8 |
C | GLY9 |
C | ARG10 |
C | ILE11 |
C | ASP32 |
C | THR33 |
C | ARG77 |
C | GLY95 |
C | THR96 |
C | GLY97 |
C | PHE99 |
C | THR119 |
C | ALA120 |
C | CYS149 |
C | ASN313 |
C | SO4402 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 402 |
Chain | Residue |
C | THR179 |
C | ASP181 |
C | ARG231 |
C | NAD401 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 C 403 |
Chain | Residue |
C | HOH512 |
C | SER148 |
C | THR150 |
C | THR208 |
C | GLY209 |
C | ALA210 |
site_id | BC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 404 |
Chain | Residue |
C | GLU253 |
C | ASN256 |
C | ARG260 |
E | GLU103 |
site_id | BC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 C 405 |
Chain | Residue |
C | PRO126 |
C | THR127 |
C | LEU216 |
site_id | BC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 C 406 |
Chain | Residue |
C | LYS122 |
C | HOH552 |
O | SER138 |
O | HIS139 |
O | ASP140 |
O | LYS333 |
site_id | BC9 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE NAD D 401 |
Chain | Residue |
D | GLY7 |
D | PHE8 |
D | GLY9 |
D | ARG10 |
D | ILE11 |
D | ASN31 |
D | ASP32 |
D | THR33 |
D | ARG77 |
D | GLY97 |
D | VAL98 |
D | THR119 |
D | ALA120 |
D | CYS149 |
D | ASN313 |
D | GLU314 |
D | TYR317 |
D | HOH508 |
I | GLU69 |
I | TYR76 |
site_id | CC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 D 402 |
Chain | Residue |
D | GLU253 |
D | ASN256 |
D | ARG260 |
D | HOH550 |
site_id | CC2 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE NAD E 401 |
Chain | Residue |
E | PHE8 |
E | GLY9 |
E | ARG10 |
E | ILE11 |
E | ASP32 |
E | ARG77 |
E | THR96 |
E | GLY97 |
E | PHE99 |
E | THR119 |
E | ALA120 |
E | CYS149 |
E | THR179 |
E | ASN313 |
E | TYR317 |
E | SO4402 |
H | SER188 |
N | GLU72 |
site_id | CC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 E 402 |
Chain | Residue |
E | THR179 |
E | ASP181 |
E | ARG195 |
E | ARG231 |
E | NAD401 |
site_id | CC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 E 403 |
Chain | Residue |
E | SER148 |
E | THR150 |
E | SER207 |
E | THR208 |
E | GLY209 |
E | ALA210 |
site_id | CC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 E 404 |
Chain | Residue |
E | GLU253 |
E | ASN256 |
E | ARG260 |
site_id | CC6 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE NAD F 401 |
Chain | Residue |
F | GLY7 |
F | PHE8 |
F | GLY9 |
F | ARG10 |
F | ILE11 |
F | ASP32 |
F | THR33 |
F | ASN76 |
F | ARG77 |
F | GLY95 |
F | THR96 |
F | GLY97 |
F | VAL98 |
F | PHE99 |
F | THR119 |
F | ALA120 |
F | CYS149 |
F | ASN313 |
F | SO4402 |
G | SER188 |
M | GLU72 |
site_id | CC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 F 402 |
Chain | Residue |
F | THR179 |
F | ARG195 |
F | ARG231 |
F | NAD401 |
site_id | CC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 F 403 |
Chain | Residue |
F | SER148 |
F | THR150 |
F | THR208 |
F | ALA210 |
site_id | CC9 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE NAD G 401 |
Chain | Residue |
F | SER188 |
G | GLY7 |
G | GLY9 |
G | ARG10 |
G | ILE11 |
G | ASN31 |
G | ASP32 |
G | THR33 |
G | ARG77 |
G | GLY95 |
G | THR96 |
G | GLY97 |
G | PHE99 |
G | THR119 |
G | ALA120 |
G | CYS149 |
G | ASN313 |
G | GLU314 |
G | TYR317 |
G | HOH506 |
G | HOH507 |
M | TYR76 |
M | ASP77 |
site_id | DC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 G 402 |
Chain | Residue |
G | GLU253 |
G | ASN256 |
G | ARG260 |
G | SER294 |
site_id | DC2 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE NAD H 401 |
Chain | Residue |
E | SER188 |
H | GLY7 |
H | PHE8 |
H | GLY9 |
H | ARG10 |
H | ILE11 |
H | ASN31 |
H | ASP32 |
H | THR33 |
H | ARG77 |
H | GLY95 |
H | GLY97 |
H | THR119 |
H | ALA120 |
H | CYS149 |
H | THR179 |
H | ASN313 |
H | GLU314 |
H | TYR317 |
H | HOH505 |
N | GLU69 |
N | TYR76 |
site_id | DC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 H 402 |
Chain | Residue |
H | GLU253 |
H | ASN256 |
H | ARG260 |
H | SER294 |
site_id | DC4 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE NAD O 401 |
Chain | Residue |
K | GLU69 |
K | TYR76 |
K | HOH103 |
O | GLY7 |
O | PHE8 |
O | GLY9 |
O | ARG10 |
O | ILE11 |
O | ASP32 |
O | THR33 |
O | ARG77 |
O | GLY95 |
O | THR96 |
O | GLY97 |
O | PHE99 |
O | THR119 |
O | CYS149 |
O | SER188 |
O | ASN313 |
O | TYR317 |
O | HOH506 |
O | HOH521 |
O | HOH571 |
site_id | DC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 O 402 |
Chain | Residue |
O | GLU253 |
O | ASN256 |
O | ARG260 |
site_id | DC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 O 403 |
Chain | Residue |
O | ARG194 |
Q | SER295 |
Q | LEU296 |
site_id | DC7 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE NAD Q 401 |
Chain | Residue |
L | GLU69 |
Q | GLY7 |
Q | PHE8 |
Q | GLY9 |
Q | ARG10 |
Q | ILE11 |
Q | ASP32 |
Q | THR33 |
Q | ARG77 |
Q | GLY95 |
Q | THR96 |
Q | GLY97 |
Q | PHE99 |
Q | THR119 |
Q | ALA120 |
Q | CYS149 |
Q | ASN313 |
Q | TYR317 |
Q | SO4402 |
site_id | DC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 Q 402 |
Chain | Residue |
Q | THR179 |
Q | ASP181 |
Q | ARG195 |
Q | NAD401 |
Q | HOH528 |
site_id | DC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 Q 403 |
Chain | Residue |
Q | SER148 |
Q | THR150 |
Q | THR208 |
Q | GLY209 |
Q | ALA210 |
Q | HOH518 |
Q | HOH537 |
Q | HOH559 |
site_id | EC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 Q 404 |
Chain | Residue |
Q | ILE125 |
Q | PRO126 |
Q | THR127 |
Q | LEU216 |
site_id | EC2 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE SO4 Q 405 |
Chain | Residue |
O | HOH561 |
Functional Information from PROSITE/UniProt
site_id | PS00071 |
Number of Residues | 8 |
Details | GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL |
Chain | Residue | Details |
A | ALA147-LEU154 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 10 |
Details | ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU10009 |
Chain | Residue | Details |
A | CYS149 | |
Q | CYS149 | |
B | CYS149 | |
C | CYS149 | |
D | CYS149 | |
E | CYS149 | |
F | CYS149 | |
G | CYS149 | |
H | CYS149 | |
O | CYS149 |
site_id | SWS_FT_FI2 |
Number of Residues | 40 |
Details | BINDING: BINDING => ECO:0000269|PubMed:20516587, ECO:0000269|PubMed:22514274 |
Chain | Residue | Details |
A | ARG10 | |
C | ASP32 | |
C | ARG77 | |
C | ASN313 | |
D | ARG10 | |
D | ASP32 | |
D | ARG77 | |
D | ASN313 | |
E | ARG10 | |
E | ASP32 | |
E | ARG77 | |
A | ASP32 | |
E | ASN313 | |
F | ARG10 | |
F | ASP32 | |
F | ARG77 | |
F | ASN313 | |
G | ARG10 | |
G | ASP32 | |
G | ARG77 | |
G | ASN313 | |
H | ARG10 | |
A | ARG77 | |
H | ASP32 | |
H | ARG77 | |
H | ASN313 | |
O | ARG10 | |
O | ASP32 | |
O | ARG77 | |
O | ASN313 | |
Q | ARG10 | |
Q | ASP32 | |
Q | ARG77 | |
A | ASN313 | |
Q | ASN313 | |
B | ARG10 | |
B | ASP32 | |
B | ARG77 | |
B | ASN313 | |
C | ARG10 |
site_id | SWS_FT_FI3 |
Number of Residues | 50 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | SER148 | |
B | ARG231 | |
C | SER148 | |
C | THR179 | |
C | ARG195 | |
C | THR208 | |
C | ARG231 | |
D | SER148 | |
D | THR179 | |
D | ARG195 | |
D | THR208 | |
A | THR179 | |
D | ARG231 | |
E | SER148 | |
E | THR179 | |
E | ARG195 | |
E | THR208 | |
E | ARG231 | |
F | SER148 | |
F | THR179 | |
F | ARG195 | |
F | THR208 | |
A | ARG195 | |
F | ARG231 | |
G | SER148 | |
G | THR179 | |
G | ARG195 | |
G | THR208 | |
G | ARG231 | |
H | SER148 | |
H | THR179 | |
H | ARG195 | |
H | THR208 | |
A | THR208 | |
H | ARG231 | |
O | SER148 | |
O | THR179 | |
O | ARG195 | |
O | THR208 | |
O | ARG231 | |
Q | SER148 | |
Q | THR179 | |
Q | ARG195 | |
Q | THR208 | |
A | ARG231 | |
Q | ARG231 | |
B | SER148 | |
B | THR179 | |
B | ARG195 | |
B | THR208 |
site_id | SWS_FT_FI4 |
Number of Residues | 10 |
Details | SITE: Activates thiol group during catalysis => ECO:0000250 |
Chain | Residue | Details |
A | HIS176 | |
Q | HIS176 | |
B | HIS176 | |
C | HIS176 | |
D | HIS176 | |
E | HIS176 | |
F | HIS176 | |
G | HIS176 | |
H | HIS176 | |
O | HIS176 |