3RUX
Crystal structure of biotin-protein ligase BirA from Mycobacterium tuberculosis in complex with an acylsulfamide bisubstrate inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004077 | molecular_function | biotin--[biotin carboxyl-carrier protein] ligase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016874 | molecular_function | ligase activity |
| A | 0036094 | molecular_function | small molecule binding |
| A | 0036211 | biological_process | protein modification process |
| A | 0043687 | biological_process | post-translational protein modification |
| B | 0004077 | molecular_function | biotin--[biotin carboxyl-carrier protein] ligase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016874 | molecular_function | ligase activity |
| B | 0036094 | molecular_function | small molecule binding |
| B | 0036211 | biological_process | protein modification process |
| B | 0043687 | biological_process | post-translational protein modification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE BS5 A 1001 |
| Chain | Residue |
| A | SER38 |
| A | GLY73 |
| A | TRP74 |
| A | ALA75 |
| A | GLN81 |
| A | ILE83 |
| A | ASN130 |
| A | LYS138 |
| A | GLY141 |
| A | ILE142 |
| A | LEU143 |
| A | THR39 |
| A | VAL155 |
| A | GLY156 |
| A | ASN158 |
| A | VAL166 |
| A | ASP167 |
| A | ALA170 |
| A | HOH289 |
| A | HOH382 |
| A | HOH531 |
| A | ASN40 |
| A | GLN63 |
| A | GLY66 |
| A | ARG67 |
| A | GLY68 |
| A | ARG69 |
| A | ARG72 |
| site_id | AC2 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE BS5 B 1002 |
| Chain | Residue |
| A | HOH334 |
| B | SER38 |
| B | THR39 |
| B | ASN40 |
| B | GLN63 |
| B | GLY66 |
| B | ARG67 |
| B | GLY68 |
| B | ARG69 |
| B | ARG72 |
| B | GLY73 |
| B | TRP74 |
| B | ALA75 |
| B | GLN81 |
| B | ILE83 |
| B | ASN130 |
| B | LYS138 |
| B | GLY141 |
| B | ILE142 |
| B | VAL155 |
| B | GLY156 |
| B | ASN158 |
| B | VAL166 |
| B | ASP167 |
| B | ALA170 |
| B | HOH322 |
| B | HOH339 |
| B | HOH384 |
| B | HOH501 |
