3RU8
Structure of an HIV epitope scaffold in complex with neutralizing antibody b12 Fab
Functional Information from GO Data
Chain | GOid | namespace | contents |
L | 0002250 | biological_process | adaptive immune response |
L | 0003823 | molecular_function | antigen binding |
L | 0005576 | cellular_component | extracellular region |
L | 0005615 | cellular_component | extracellular space |
L | 0005886 | cellular_component | plasma membrane |
L | 0006955 | biological_process | immune response |
L | 0016064 | biological_process | immunoglobulin mediated immune response |
L | 0019814 | cellular_component | immunoglobulin complex |
L | 0050853 | biological_process | B cell receptor signaling pathway |
L | 0070062 | cellular_component | extracellular exosome |
L | 0071735 | cellular_component | IgG immunoglobulin complex |
L | 0071738 | cellular_component | IgD immunoglobulin complex |
L | 0071742 | cellular_component | IgE immunoglobulin complex |
L | 0071745 | cellular_component | IgA immunoglobulin complex |
L | 0071753 | cellular_component | IgM immunoglobulin complex |
L | 0072562 | cellular_component | blood microparticle |
X | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
X | 0030245 | biological_process | cellulose catabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL L 216 |
Chain | Residue |
L | GLN38 |
L | ILE59 |
L | SER60 |
L | ARG62 |
L | PHE63 |
L | GLU82 |
L | ASP83 |
L | HOH265 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL X 283 |
Chain | Residue |
X | ASP144 |
X | GLY146 |
X | MET156 |
X | HOH318 |
X | HOH356 |
X | TYR110 |
site_id | AC3 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE GOL L 217 |
Chain | Residue |
H | PHE174 |
H | PRO175 |
H | VAL177 |
H | SER186 |
H | LEU187 |
H | SER188 |
L | GLN161 |
L | GLU162 |
L | SER177 |
L | SER178 |
L | THR179 |
L | HOH297 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL X 284 |
Chain | Residue |
X | LYS247 |
X | LEU248 |
X | GLU251 |
X | GLY260 |
X | HOH313 |
X | HOH379 |
X | HOH403 |
Functional Information from PROSITE/UniProt
site_id | PS00290 |
Number of Residues | 7 |
Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
Chain | Residue | Details |
H | TYR206-HIS212 | |
L | TYR193-HIS199 |