3RU8

Structure of an HIV epitope scaffold in complex with neutralizing antibody b12 Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0003823	molecular_function	antigen binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0016064	biological_process	immunoglobulin mediated immune response
L	0019814	cellular_component	immunoglobulin complex
L	0050853	biological_process	B cell receptor signaling pathway
L	0070062	cellular_component	extracellular exosome
L	0071735	cellular_component	IgG immunoglobulin complex
L	0072562	cellular_component	blood microparticle
X	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
X	0030245	biological_process	cellulose catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL L 216

Chain	Residue
L	GLN38
L	ILE59
L	SER60
L	ARG62
L	PHE63
L	GLU82
L	ASP83
L	HOH265

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL X 283

Chain	Residue
X	ASP144
X	GLY146
X	MET156
X	HOH318
X	HOH356
X	TYR110

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site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GOL L 217

Chain	Residue
H	PHE174
H	PRO175
H	VAL177
H	SER186
H	LEU187
H	SER188
L	GLN161
L	GLU162
L	SER177
L	SER178
L	THR179
L	HOH297

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site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL X 284

Chain	Residue
X	LYS247
X	LEU248
X	GLU251
X	GLY260
X	HOH313
X	HOH379
X	HOH403

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR206-HIS212
L	TYR193-HIS199

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	97
Details	Domain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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