3RTF
Chlorowillardiine bound to the ligand binding domain of GluA2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
| F | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| F | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE CWD B 800 |
| Chain | Residue |
| B | TYR61 |
| B | THR174 |
| B | LEU192 |
| B | GLU193 |
| B | MET196 |
| B | HOH263 |
| B | HOH267 |
| B | HOH271 |
| B | PRO89 |
| B | LEU90 |
| B | THR91 |
| B | ARG96 |
| B | LEU138 |
| B | GLY141 |
| B | SER142 |
| B | THR143 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ZN B 1 |
| Chain | Residue |
| B | HIS23 |
| D | ASP65 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 2 |
| Chain | Residue |
| B | GLU42 |
| B | LYS45 |
| B | HIS46 |
| F | GLU166 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE CWD D 800 |
| Chain | Residue |
| D | TYR61 |
| D | PRO89 |
| D | LEU90 |
| D | THR91 |
| D | ARG96 |
| D | LEU138 |
| D | GLY141 |
| D | SER142 |
| D | THR143 |
| D | THR174 |
| D | LEU192 |
| D | GLU193 |
| D | MET196 |
| D | TYR220 |
| D | HOH267 |
| D | HOH286 |
| D | HOH316 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 1 |
| Chain | Residue |
| D | GLU42 |
| D | LYS45 |
| D | HIS46 |
| D | HOH531 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN D 2 |
| Chain | Residue |
| D | HIS23 |
| D | GLU24 |
| F | HIS23 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE CWD F 800 |
| Chain | Residue |
| F | TYR61 |
| F | PRO89 |
| F | LEU90 |
| F | THR91 |
| F | ARG96 |
| F | LEU138 |
| F | GLY141 |
| F | SER142 |
| F | THR143 |
| F | THR174 |
| F | LEU192 |
| F | GLU193 |
| F | MET196 |
| F | TYR220 |
| F | HOH266 |
| F | HOH271 |
| F | HOH277 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN F 1 |
| Chain | Residue |
| B | GLU166 |
| F | GLU42 |
| F | HIS46 |
| F | LEU241 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
