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3RQE

Cerebral cavernous malformation 3 (CCM3) in complex with paxillin LD1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001525biological_processangiogenesis
A0003158biological_processendothelium development
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006915biological_processapoptotic process
A0008284biological_processpositive regulation of cell population proliferation
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0019901molecular_functionprotein kinase binding
A0030335biological_processpositive regulation of cell migration
A0032874biological_processpositive regulation of stress-activated MAPK cascade
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0035023biological_processregulation of Rho protein signal transduction
A0035556biological_processintracellular signal transduction
A0036481biological_processintrinsic apoptotic signaling pathway in response to hydrogen peroxide
A0042803molecular_functionprotein homodimerization activity
A0043066biological_processnegative regulation of apoptotic process
A0043149biological_processstress fiber assembly
A0043406biological_processpositive regulation of MAP kinase activity
A0044319biological_processwound healing, spreading of cells
A0045747biological_processpositive regulation of Notch signaling pathway
A0045765biological_processregulation of angiogenesis
A0050821biological_processprotein stabilization
A0051683biological_processestablishment of Golgi localization
A0070062cellular_componentextracellular exosome
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
A0090168biological_processGolgi reassembly
A0090316biological_processpositive regulation of intracellular protein transport
A0090443cellular_componentFAR/SIN/STRIPAK complex
A1903358biological_processregulation of Golgi organization
A1903588biological_processnegative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
A1990830biological_processcellular response to leukemia inhibitory factor
B0000139cellular_componentGolgi membrane
B0001525biological_processangiogenesis
B0003158biological_processendothelium development
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006915biological_processapoptotic process
B0008284biological_processpositive regulation of cell population proliferation
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0019901molecular_functionprotein kinase binding
B0030335biological_processpositive regulation of cell migration
B0032874biological_processpositive regulation of stress-activated MAPK cascade
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0035023biological_processregulation of Rho protein signal transduction
B0035556biological_processintracellular signal transduction
B0036481biological_processintrinsic apoptotic signaling pathway in response to hydrogen peroxide
B0042803molecular_functionprotein homodimerization activity
B0043066biological_processnegative regulation of apoptotic process
B0043149biological_processstress fiber assembly
B0043406biological_processpositive regulation of MAP kinase activity
B0044319biological_processwound healing, spreading of cells
B0045747biological_processpositive regulation of Notch signaling pathway
B0045765biological_processregulation of angiogenesis
B0050821biological_processprotein stabilization
B0051683biological_processestablishment of Golgi localization
B0070062cellular_componentextracellular exosome
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
B0090168biological_processGolgi reassembly
B0090316biological_processpositive regulation of intracellular protein transport
B0090443cellular_componentFAR/SIN/STRIPAK complex
B1903358biological_processregulation of Golgi organization
B1903588biological_processnegative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
B1990830biological_processcellular response to leukemia inhibitory factor
C0000139cellular_componentGolgi membrane
C0001525biological_processangiogenesis
C0003158biological_processendothelium development
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006915biological_processapoptotic process
C0008284biological_processpositive regulation of cell population proliferation
C0010628biological_processpositive regulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0019901molecular_functionprotein kinase binding
C0030335biological_processpositive regulation of cell migration
C0032874biological_processpositive regulation of stress-activated MAPK cascade
C0033138biological_processpositive regulation of peptidyl-serine phosphorylation
C0035023biological_processregulation of Rho protein signal transduction
C0035556biological_processintracellular signal transduction
C0036481biological_processintrinsic apoptotic signaling pathway in response to hydrogen peroxide
C0042803molecular_functionprotein homodimerization activity
C0043066biological_processnegative regulation of apoptotic process
C0043149biological_processstress fiber assembly
C0043406biological_processpositive regulation of MAP kinase activity
C0044319biological_processwound healing, spreading of cells
C0045747biological_processpositive regulation of Notch signaling pathway
C0045765biological_processregulation of angiogenesis
C0050821biological_processprotein stabilization
C0051683biological_processestablishment of Golgi localization
C0070062cellular_componentextracellular exosome
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
C0090168biological_processGolgi reassembly
C0090316biological_processpositive regulation of intracellular protein transport
C0090443cellular_componentFAR/SIN/STRIPAK complex
C1903358biological_processregulation of Golgi organization
C1903588biological_processnegative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
C1990830biological_processcellular response to leukemia inhibitory factor
D0000139cellular_componentGolgi membrane
D0001525biological_processangiogenesis
D0003158biological_processendothelium development
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006915biological_processapoptotic process
D0008284biological_processpositive regulation of cell population proliferation
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0019901molecular_functionprotein kinase binding
D0030335biological_processpositive regulation of cell migration
D0032874biological_processpositive regulation of stress-activated MAPK cascade
D0033138biological_processpositive regulation of peptidyl-serine phosphorylation
D0035023biological_processregulation of Rho protein signal transduction
D0035556biological_processintracellular signal transduction
D0036481biological_processintrinsic apoptotic signaling pathway in response to hydrogen peroxide
D0042803molecular_functionprotein homodimerization activity
D0043066biological_processnegative regulation of apoptotic process
D0043149biological_processstress fiber assembly
D0043406biological_processpositive regulation of MAP kinase activity
D0044319biological_processwound healing, spreading of cells
D0045747biological_processpositive regulation of Notch signaling pathway
D0045765biological_processregulation of angiogenesis
D0050821biological_processprotein stabilization
D0051683biological_processestablishment of Golgi localization
D0070062cellular_componentextracellular exosome
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
D0090168biological_processGolgi reassembly
D0090316biological_processpositive regulation of intracellular protein transport
D0090443cellular_componentFAR/SIN/STRIPAK complex
D1903358biological_processregulation of Golgi organization
D1903588biological_processnegative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
D1990830biological_processcellular response to leukemia inhibitory factor
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS179
BLYS179
CLYS179
DLYS179

site_idSWS_FT_FI2
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS186
BLYS186
CLYS186
DLYS186

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PDB entries from 2024-07-24

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