3RPG

Bmi1/Ring1b-UbcH5c complex structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000151	cellular_component	ubiquitin ligase complex
A	0000209	biological_process	protein polyubiquitination
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005768	cellular_component	endosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006281	biological_process	DNA repair
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006513	biological_process	protein monoubiquitination
A	0006915	biological_process	apoptotic process
A	0010008	cellular_component	endosome membrane
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0019787	molecular_function	ubiquitin-like protein transferase activity
A	0030514	biological_process	negative regulation of BMP signaling pathway
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0036211	biological_process	protein modification process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051865	biological_process	protein autoubiquitination
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0070062	cellular_component	extracellular exosome
A	0070936	biological_process	protein K48-linked ubiquitination
A	0070979	biological_process	protein K11-linked ubiquitination
A	0085020	biological_process	protein K6-linked ubiquitination
A	1903955	biological_process	positive regulation of protein targeting to mitochondrion
C	0000151	cellular_component	ubiquitin ligase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1104

Chain	Residue
B	CYS18
B	CYS21
B	CYS39
B	CYS42

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1105

Chain	Residue
B	CYS34
B	HIS36
B	CYS53
B	CYS56

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1115

Chain	Residue
C	HIS69
C	CYS87
C	CYS90
C	CYS67

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1116

Chain	Residue
C	CYS51
C	CYS54
C	CYS72
C	CYS75

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Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNInsn.GsICLdiL

Chain	Residue	Details
A	TYR74-LEU89

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site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. ClHrFCadCI

Chain	Residue	Details
C	CYS67-ILE76
B	CYS34-ILE43

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	ZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175

Chain	Residue	Details
C	CYS51-ARG91

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
C	SER2

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:25519132

Chain	Residue	Details
C	SER41

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q9CQJ4

Chain	Residue	Details
C	LYS112

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