3RP7
Crystal Structure of Klebsiella pneumoniae HpxO complexed with FAD and uric acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0004846 | molecular_function | urate oxidase activity |
| A | 0006144 | biological_process | purine nucleobase metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016709 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| A | 0019628 | biological_process | urate catabolic process |
| A | 0071949 | molecular_function | FAD binding |
| A | 0102099 | molecular_function | FAD-dependent urate hydroxylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE URC A 7579 |
| Chain | Residue |
| A | SER43 |
| A | HOH401 |
| A | HOH473 |
| A | ASN178 |
| A | ARG204 |
| A | TYR216 |
| A | PHE218 |
| A | PRO292 |
| A | ASP293 |
| A | GLY295 |
| A | FAD385 |
| site_id | AC2 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE FAD A 385 |
| Chain | Residue |
| A | ILE6 |
| A | GLY7 |
| A | GLY9 |
| A | ILE10 |
| A | GLY11 |
| A | GLU30 |
| A | ALA31 |
| A | VAL32 |
| A | ILE42 |
| A | SER43 |
| A | ARG103 |
| A | LYS123 |
| A | ARG124 |
| A | VAL125 |
| A | ALA153 |
| A | ASP154 |
| A | GLY155 |
| A | GLY284 |
| A | ASP285 |
| A | PRO292 |
| A | GLY295 |
| A | GLN296 |
| A | GLY297 |
| A | GLY298 |
| A | CYS299 |
| A | HOH386 |
| A | HOH387 |
| A | HOH395 |
| A | HOH406 |
| A | HOH474 |
| A | HOH494 |
| A | HOH522 |
| A | HOH554 |
| A | URC7579 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23259842","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3RP6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RP8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23259842","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3RP7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Involved in substrate activation for the transfer of oxygen from the flavin hydroperoxide","evidences":[{"source":"PubMed","id":"23259842","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
