3RO0

Crystal structure of Bacillus amyloliquefaciens pyroglutamyl peptidase I and terpyridine platinum(II)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
A	0016920	molecular_function	pyroglutamyl-peptidase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
B	0016920	molecular_function	pyroglutamyl-peptidase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006508	biological_process	proteolysis
C	0008234	molecular_function	cysteine-type peptidase activity
C	0016920	molecular_function	pyroglutamyl-peptidase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006508	biological_process	proteolysis
D	0008234	molecular_function	cysteine-type peptidase activity
D	0016920	molecular_function	pyroglutamyl-peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TPT A 480

Chain	Residue
A	PHE10
A	HOH284
A	HOH910
A	PHE13
A	ASN19
A	THR45
A	GLN71
A	ALA139
A	CYS144
A	HIS168
A	HOH245

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TPT B 481

Chain	Residue
B	PHE10
B	PHE13
B	THR45
B	GLN71
B	ALA139
B	CYS144
B	HIS168
B	HOH337
B	HOH923

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TPT C 482

Chain	Residue
C	PHE10
C	PHE13
C	THR45
C	GLN71
C	ALA139
C	CYS144
C	HIS168
C	HOH730

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TPT D 483

Chain	Residue
D	PHE10
D	PHE13
D	THR45
D	GLN71
D	ALA139
D	PHE142
D	CYS144
D	HIS168
D	HOH454
D	HOH728

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE TPT D 484

Chain	Residue
D	HIS158
D	HIS159
D	PRO160
D	HIS161
D	HOH507
D	HOH688

---

Functional Information from PROSITE/UniProt

site_id	PS01333
Number of Residues	17
Details	PYRASE_GLU Pyrrolidone-carboxylate peptidase glutamic acid active site. GqaGgrmqITpERVAiN

Chain	Residue	Details
A	GLY70-ASN86

---

site_id	PS01334
Number of Residues	15
Details	PYRASE_CYS Pyrrolidone-carboxylate peptidase cysteine active site. IpAaVSyTAGtFVCN

Chain	Residue	Details
A	ILE131-ASN145

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE:

Chain	Residue	Details
A	GLU81
A	CYS144
A	HIS168
B	GLU81
B	CYS144
B	HIS168
C	GLU81
C	CYS144
C	HIS168
D	GLU81
D	CYS144
D	HIS168

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 633

Chain	Residue	Details
A	GLU81	electrostatic stabiliser
A	ARG91	electrostatic stabiliser
A	HIS168	proton acceptor, proton donor
A	CYS144	electrostatic stabiliser

---

site_id	MCSA2
Number of Residues	4
Details	M-CSA 633

Chain	Residue	Details
B	CYS144	electrostatic stabiliser
B	GLU81	electrostatic stabiliser
B	ARG91	electrostatic stabiliser
B	HIS168	proton acceptor, proton donor

---

site_id	MCSA3
Number of Residues	4
Details	M-CSA 633

Chain	Residue	Details
C	GLU81	electrostatic stabiliser
C	ARG91	electrostatic stabiliser
C	HIS168	proton acceptor, proton donor
C	CYS144	electrostatic stabiliser

---

site_id	MCSA4
Number of Residues	4
Details	M-CSA 633

Chain	Residue	Details
D	GLU81	electrostatic stabiliser
D	ARG91	electrostatic stabiliser
D	HIS168	proton acceptor, proton donor
D	CYS144	electrostatic stabiliser

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