3RLG

Crystal structure of Loxosceles intermedia phospholipase D isoform 1 H12A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0006629	biological_process	lipid metabolic process
A	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 286

Chain	Residue
A	GLU32
A	ASP34
A	ASP91
A	HOH357
A	HOH475

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 287

Chain	Residue
A	ASN200

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG A 288

Chain	Residue
A	ASN41
A	LYS108
A	PGE289

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PGE A 289

Chain	Residue
A	ASP104
A	LYS107
A	LYS108
A	LYS111
A	PEG288

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site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 290

Chain	Residue
A	ASN137
A	LYS185

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site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 291

Chain	Residue
A	ASP39
A	ASN39
A	HOH387

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site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PGE A 292

Chain	Residue
A	ALA264
A	LYS268

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site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG A 293

Chain	Residue
A	LYS267

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site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 294

Chain	Residue
A	GLY180
A	ILE188
A	PHE223

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"18760322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19455508","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21301094","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21590705","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27233517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36828423","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"27233517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36828423","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21301094","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21616057","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3RLG","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3RLH","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

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