3RLG
Crystal structure of Loxosceles intermedia phospholipase D isoform 1 H12A mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 286 |
| Chain | Residue |
| A | GLU32 |
| A | ASP34 |
| A | ASP91 |
| A | HOH357 |
| A | HOH475 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 287 |
| Chain | Residue |
| A | ASN200 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG A 288 |
| Chain | Residue |
| A | ASN41 |
| A | LYS108 |
| A | PGE289 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE A 289 |
| Chain | Residue |
| A | ASP104 |
| A | LYS107 |
| A | LYS108 |
| A | LYS111 |
| A | PEG288 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 290 |
| Chain | Residue |
| A | ASN137 |
| A | LYS185 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 291 |
| Chain | Residue |
| A | ASP39 |
| A | ASN39 |
| A | HOH387 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PGE A 292 |
| Chain | Residue |
| A | ALA264 |
| A | LYS268 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG A 293 |
| Chain | Residue |
| A | LYS267 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 294 |
| Chain | Residue |
| A | GLY180 |
| A | ILE188 |
| A | PHE223 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"18760322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19455508","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21301094","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21590705","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27233517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36828423","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"27233517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36828423","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21301094","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21616057","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3RLG","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3RLH","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
