3RII

Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0016579	biological_process	protein deubiquitination
A	0031011	cellular_component	Ino80 complex
A	0070628	molecular_function	proteasome binding
B	0004843	molecular_function	cysteine-type deubiquitinase activity
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0016579	biological_process	protein deubiquitination
B	0031011	cellular_component	Ino80 complex
B	0070628	molecular_function	proteasome binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 229

Chain	Residue
A	PHE56
A	LYS57
A	TRP58
A	GLN59
A	GLU62
A	TYR211
A	HOH288

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 230

Chain	Residue
A	HOH349
B	HOH351
A	GLU109
A	GLU113

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 229

Chain	Residue
B	ALA80
B	GLN91
B	ALA92
B	SER95
B	GLY180
B	HOH335

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Important for enzyme activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9WUP7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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