3RIA
C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and iodide.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE IVM A 348 |
| Chain | Residue |
| A | SER260 |
| B | PRO223 |
| B | MET226 |
| A | ASP277 |
| A | GLY281 |
| A | MET284 |
| A | THR285 |
| A | PHE288 |
| B | LEU218 |
| B | GLN219 |
| B | ILE222 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE IVM C 349 |
| Chain | Residue |
| B | SER260 |
| B | ILE273 |
| B | ASP277 |
| B | GLY281 |
| B | MET284 |
| B | THR285 |
| B | PHE288 |
| C | LEU218 |
| C | GLN219 |
| C | ILE222 |
| C | PRO223 |
| C | MET226 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE IVM C 350 |
| Chain | Residue |
| C | SER260 |
| C | ASP277 |
| C | GLY281 |
| C | MET284 |
| C | THR285 |
| C | PHE288 |
| D | LEU218 |
| D | GLN219 |
| D | ILE222 |
| D | PRO223 |
| D | MET226 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE IVM E 348 |
| Chain | Residue |
| D | SER260 |
| D | ASP277 |
| D | ILE280 |
| D | MET284 |
| D | PHE288 |
| E | LEU218 |
| E | GLN219 |
| E | ILE222 |
| E | PRO223 |
| E | MET226 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE IVM E 349 |
| Chain | Residue |
| A | LEU218 |
| A | GLN219 |
| A | ILE222 |
| A | MET226 |
| E | SER260 |
| E | ASP277 |
| E | ILE280 |
| E | GLY281 |
| E | MET284 |
| E | THR285 |
| E | PHE288 |
| E | OCT350 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE LMT A 349 |
| Chain | Residue |
| A | HIS299 |
| A | ASN302 |
| A | ALA303 |
| A | GLY304 |
| B | LMT348 |
| L | VAL205 |
| L | GLU206 |
| L | LYS207 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LMT B 348 |
| Chain | Residue |
| A | LMT349 |
| B | TRP236 |
| B | LEU317 |
| B | ARG320 |
| B | UND350 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE LMT A 350 |
| Chain | Residue |
| A | LYS210 |
| A | TRP335 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE OCT D 348 |
| Chain | Residue |
| D | PHE286 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE OCT E 350 |
| Chain | Residue |
| E | THR285 |
| E | PHE286 |
| E | IVM349 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE OCT B 349 |
| Chain | Residue |
| B | THR285 |
| B | PHE286 |
| B | CYS289 |
| B | PHE323 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UND B 350 |
| Chain | Residue |
| B | ARG320 |
| B | PRO324 |
| B | LMT348 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD D 349 |
| Chain | Residue |
| C | ILE242 |
| C | PRO243 |
| D | ALA241 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD E 351 |
| Chain | Residue |
| D | PRO243 |
| E | ALA241 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 351 |
| Chain | Residue |
| A | ALA241 |
| E | ILE242 |
| E | PRO243 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD B 351 |
| Chain | Residue |
| A | PRO243 |
| B | ALA241 |
| B | PRO243 |
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpMyLqyYPmDvqqC |
| Chain | Residue | Details |
| A | CYS130-CYS144 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH |
| Chain | Residue | Details |
| K | TYR194-HIS200 |
